Evaluation of Peripheral Blood Concentrations of Phoenixin, Spexin, Nesfatin-1 and Kisspeptin as Potential Biomarkers of Bipolar <span style="font-variant: small-caps">D</span>isorder in the Pediatric Population
There are some initial suggestions in the literature that phoenixin, spexin, nesfatin-1 and kisspeptin may play a role in the pathogenesis of affective disorders. Therefore, they may also be cautiously considered as potential diagnostic or predictive biomarkers of BD. This study aimed to evaluate th...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/12/1/84 |
| _version_ | 1827369778162958336 |
|---|---|
| author | Lena Cichoń Artur Pałasz Krzysztof M. Wilczyński Aleksandra Suszka-Świtek Anna Żmijowska Ireneusz Jelonek Małgorzata Janas-Kozik |
| author_facet | Lena Cichoń Artur Pałasz Krzysztof M. Wilczyński Aleksandra Suszka-Świtek Anna Żmijowska Ireneusz Jelonek Małgorzata Janas-Kozik |
| author_sort | Lena Cichoń |
| collection | DOAJ |
| description | There are some initial suggestions in the literature that phoenixin, spexin, nesfatin-1 and kisspeptin may play a role in the pathogenesis of affective disorders. Therefore, they may also be cautiously considered as potential diagnostic or predictive biomarkers of BD. This study aimed to evaluate the levels of the aforementioned neuropeptides in the peripheral blood of children and adolescents with bipolar. This study included 122 individuals: 67 persons with diagnosed bipolar disorder types I and II constituted the study group, and 55 healthy persons were included in the control group. Statistically significant differences in the concentrations of neuropeptides between the control and study groups were noted in relation to nesfatin-1 and spexin (although spexin lost statistical significance after introducing the Bonferroni correction). In a logistic regression analysis, an increased risk of bipolar disorder was noted for a decrease in nesfatin-1 concentration. Lower levels of nesfatin-1 seemed to be a significant risk factor for the development of bipolar disorder types I and II. Furthermore, the occurrence of bipolar disorder was associated with significantly elevated levels of spexin. None of the analyzed neuropeptides was significantly correlated with the number of symptoms of bipolar disorder. |
| first_indexed | 2024-03-08T09:57:27Z |
| format | Article |
| id | doaj.art-0cac30b74f4e46f0b33b56039299c541 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T09:57:27Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-0cac30b74f4e46f0b33b56039299c5412024-01-29T13:46:59ZengMDPI AGBiomedicines2227-90592023-12-011218410.3390/biomedicines12010084Evaluation of Peripheral Blood Concentrations of Phoenixin, Spexin, Nesfatin-1 and Kisspeptin as Potential Biomarkers of Bipolar <span style="font-variant: small-caps">D</span>isorder in the Pediatric PopulationLena Cichoń0Artur Pałasz1Krzysztof M. Wilczyński2Aleksandra Suszka-Świtek3Anna Żmijowska4Ireneusz Jelonek5Małgorzata Janas-Kozik6Department of Developmental Age Psychiatry and Psychotherapy, John Paul II Pediatric Centre in Sosnowiec, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Zapolskiej 3, 41-218 Sosnowiec, PolandDepartment of Histology, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Medyków 18, 40-752 Katowice, PolandDepartment of Developmental Age Psychiatry and Psychotherapy, John Paul II Pediatric Centre in Sosnowiec, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Zapolskiej 3, 41-218 Sosnowiec, PolandDepartment of Histology, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Medyków 18, 40-752 Katowice, PolandDepartment of Developmental Age Psychiatry and Psychotherapy, John Paul II Pediatric Centre in Sosnowiec, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Zapolskiej 3, 41-218 Sosnowiec, PolandDepartment of Developmental Age Psychiatry and Psychotherapy, John Paul II Pediatric Centre in Sosnowiec, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Zapolskiej 3, 41-218 Sosnowiec, PolandDepartment of Developmental Age Psychiatry and Psychotherapy, John Paul II Pediatric Centre in Sosnowiec, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Zapolskiej 3, 41-218 Sosnowiec, PolandThere are some initial suggestions in the literature that phoenixin, spexin, nesfatin-1 and kisspeptin may play a role in the pathogenesis of affective disorders. Therefore, they may also be cautiously considered as potential diagnostic or predictive biomarkers of BD. This study aimed to evaluate the levels of the aforementioned neuropeptides in the peripheral blood of children and adolescents with bipolar. This study included 122 individuals: 67 persons with diagnosed bipolar disorder types I and II constituted the study group, and 55 healthy persons were included in the control group. Statistically significant differences in the concentrations of neuropeptides between the control and study groups were noted in relation to nesfatin-1 and spexin (although spexin lost statistical significance after introducing the Bonferroni correction). In a logistic regression analysis, an increased risk of bipolar disorder was noted for a decrease in nesfatin-1 concentration. Lower levels of nesfatin-1 seemed to be a significant risk factor for the development of bipolar disorder types I and II. Furthermore, the occurrence of bipolar disorder was associated with significantly elevated levels of spexin. None of the analyzed neuropeptides was significantly correlated with the number of symptoms of bipolar disorder.https://www.mdpi.com/2227-9059/12/1/84bipolar disorderneuropeptidesspexinkisspeptinnesfatin-1phoenixin |
| spellingShingle | Lena Cichoń Artur Pałasz Krzysztof M. Wilczyński Aleksandra Suszka-Świtek Anna Żmijowska Ireneusz Jelonek Małgorzata Janas-Kozik Evaluation of Peripheral Blood Concentrations of Phoenixin, Spexin, Nesfatin-1 and Kisspeptin as Potential Biomarkers of Bipolar <span style="font-variant: small-caps">D</span>isorder in the Pediatric Population Biomedicines bipolar disorder neuropeptides spexin kisspeptin nesfatin-1 phoenixin |
| title | Evaluation of Peripheral Blood Concentrations of Phoenixin, Spexin, Nesfatin-1 and Kisspeptin as Potential Biomarkers of Bipolar <span style="font-variant: small-caps">D</span>isorder in the Pediatric Population |
| title_full | Evaluation of Peripheral Blood Concentrations of Phoenixin, Spexin, Nesfatin-1 and Kisspeptin as Potential Biomarkers of Bipolar <span style="font-variant: small-caps">D</span>isorder in the Pediatric Population |
| title_fullStr | Evaluation of Peripheral Blood Concentrations of Phoenixin, Spexin, Nesfatin-1 and Kisspeptin as Potential Biomarkers of Bipolar <span style="font-variant: small-caps">D</span>isorder in the Pediatric Population |
| title_full_unstemmed | Evaluation of Peripheral Blood Concentrations of Phoenixin, Spexin, Nesfatin-1 and Kisspeptin as Potential Biomarkers of Bipolar <span style="font-variant: small-caps">D</span>isorder in the Pediatric Population |
| title_short | Evaluation of Peripheral Blood Concentrations of Phoenixin, Spexin, Nesfatin-1 and Kisspeptin as Potential Biomarkers of Bipolar <span style="font-variant: small-caps">D</span>isorder in the Pediatric Population |
| title_sort | evaluation of peripheral blood concentrations of phoenixin spexin nesfatin 1 and kisspeptin as potential biomarkers of bipolar span style font variant small caps d span isorder in the pediatric population |
| topic | bipolar disorder neuropeptides spexin kisspeptin nesfatin-1 phoenixin |
| url | https://www.mdpi.com/2227-9059/12/1/84 |
| work_keys_str_mv | AT lenacichon evaluationofperipheralbloodconcentrationsofphoenixinspexinnesfatin1andkisspeptinaspotentialbiomarkersofbipolarspanstylefontvariantsmallcapsdspanisorderinthepediatricpopulation AT arturpałasz evaluationofperipheralbloodconcentrationsofphoenixinspexinnesfatin1andkisspeptinaspotentialbiomarkersofbipolarspanstylefontvariantsmallcapsdspanisorderinthepediatricpopulation AT krzysztofmwilczynski evaluationofperipheralbloodconcentrationsofphoenixinspexinnesfatin1andkisspeptinaspotentialbiomarkersofbipolarspanstylefontvariantsmallcapsdspanisorderinthepediatricpopulation AT aleksandrasuszkaswitek evaluationofperipheralbloodconcentrationsofphoenixinspexinnesfatin1andkisspeptinaspotentialbiomarkersofbipolarspanstylefontvariantsmallcapsdspanisorderinthepediatricpopulation AT annazmijowska evaluationofperipheralbloodconcentrationsofphoenixinspexinnesfatin1andkisspeptinaspotentialbiomarkersofbipolarspanstylefontvariantsmallcapsdspanisorderinthepediatricpopulation AT ireneuszjelonek evaluationofperipheralbloodconcentrationsofphoenixinspexinnesfatin1andkisspeptinaspotentialbiomarkersofbipolarspanstylefontvariantsmallcapsdspanisorderinthepediatricpopulation AT małgorzatajanaskozik evaluationofperipheralbloodconcentrationsofphoenixinspexinnesfatin1andkisspeptinaspotentialbiomarkersofbipolarspanstylefontvariantsmallcapsdspanisorderinthepediatricpopulation |