The Protective Effects of Apigenin Against Radiation‐Induced Intestinal Injury
Radiation-induced intestinal injury (RIII) restricts the therapeutic efficacy of radiotherapy in abdominal or pelvic malignancies. Also, intestinal injury is a major cause of death following exposure to high doses of radiation in nuclear accidents. No safe and effective prophylactics or therapeutics...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-07-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/15593258221113791 |
| _version_ | 1818005768556773376 |
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| author | Danjie Liu Renjun Peng Zhongmin Chen Huijie Yu Sinian Wang Suhe Dong Wei Li Wen Shao Jing Dai Fengsheng Li Qisheng Jiang Wanjun Sun |
| author_facet | Danjie Liu Renjun Peng Zhongmin Chen Huijie Yu Sinian Wang Suhe Dong Wei Li Wen Shao Jing Dai Fengsheng Li Qisheng Jiang Wanjun Sun |
| author_sort | Danjie Liu |
| collection | DOAJ |
| description | Radiation-induced intestinal injury (RIII) restricts the therapeutic efficacy of radiotherapy in abdominal or pelvic malignancies. Also, intestinal injury is a major cause of death following exposure to high doses of radiation in nuclear accidents. No safe and effective prophylactics or therapeutics for RIII are currently available. Here, we reported that the apigenin, a natural dietary flavone, prolonged the survival in c57 mice after lethal irradiation. Apigenin pretreatment brought about accelerated restoration of crypt-villus structure, including enhanced regenerated crypts, more differentiated epithelium cells, and increased villus length. In addition, intestinal crypt cells in the apigenin-treated group exhibited more proliferation and less apoptosis. Furthermore, apigenin increased the expression of Nrf2 and its downstream target gene HO-1, and decreased oxidative stress after irradiation. In conclusion, our findings demonstrate the radioprotective efficacy of apigenin. Apigenin has the potential to be used as a radioprotectant in cancer therapy and nuclear accidents. |
| first_indexed | 2024-04-14T04:49:53Z |
| format | Article |
| id | doaj.art-0cac4ba22efd48bb9241fbe2d9c301eb |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-04-14T04:49:53Z |
| publishDate | 2022-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-0cac4ba22efd48bb9241fbe2d9c301eb2022-12-22T02:11:19ZengSAGE PublishingDose-Response1559-32582022-07-012010.1177/15593258221113791The Protective Effects of Apigenin Against Radiation‐Induced Intestinal InjuryDanjie LiuRenjun PengZhongmin ChenHuijie YuSinian WangSuhe DongWei LiWen ShaoJing DaiFengsheng LiQisheng JiangWanjun SunRadiation-induced intestinal injury (RIII) restricts the therapeutic efficacy of radiotherapy in abdominal or pelvic malignancies. Also, intestinal injury is a major cause of death following exposure to high doses of radiation in nuclear accidents. No safe and effective prophylactics or therapeutics for RIII are currently available. Here, we reported that the apigenin, a natural dietary flavone, prolonged the survival in c57 mice after lethal irradiation. Apigenin pretreatment brought about accelerated restoration of crypt-villus structure, including enhanced regenerated crypts, more differentiated epithelium cells, and increased villus length. In addition, intestinal crypt cells in the apigenin-treated group exhibited more proliferation and less apoptosis. Furthermore, apigenin increased the expression of Nrf2 and its downstream target gene HO-1, and decreased oxidative stress after irradiation. In conclusion, our findings demonstrate the radioprotective efficacy of apigenin. Apigenin has the potential to be used as a radioprotectant in cancer therapy and nuclear accidents.https://doi.org/10.1177/15593258221113791 |
| spellingShingle | Danjie Liu Renjun Peng Zhongmin Chen Huijie Yu Sinian Wang Suhe Dong Wei Li Wen Shao Jing Dai Fengsheng Li Qisheng Jiang Wanjun Sun The Protective Effects of Apigenin Against Radiation‐Induced Intestinal Injury Dose-Response |
| title | The Protective Effects of Apigenin Against Radiation‐Induced Intestinal Injury |
| title_full | The Protective Effects of Apigenin Against Radiation‐Induced Intestinal Injury |
| title_fullStr | The Protective Effects of Apigenin Against Radiation‐Induced Intestinal Injury |
| title_full_unstemmed | The Protective Effects of Apigenin Against Radiation‐Induced Intestinal Injury |
| title_short | The Protective Effects of Apigenin Against Radiation‐Induced Intestinal Injury |
| title_sort | protective effects of apigenin against radiation induced intestinal injury |
| url | https://doi.org/10.1177/15593258221113791 |
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