Diverse Effects of Combinations of Maternal-Neonatal VDR Polymorphisms and 25-Hydroxyvitamin D Concentrations on Neonatal Birth Anthropometry: Functional Phenocopy Variability Dependence, Highlights the Need for Targeted Maternal 25-Hydroxyvitamin D Cut-Offs during Pregnancy
Vitamin D receptor (VDR) polymorphisms have been associated with a plethora of adverse pregnancy and offspring outcomes. The aim of this study was to evaluate the combined effect of maternal and neonatal VDR polymorphisms (ApaI, TaqI, BsmI, FokI, Tru9I) and different maternal and neonatal 25(OH)D cu...
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MDPI AG
2021-01-01
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| Series: | Nutrients |
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| author | Spyridon N. Karras Erdinç Dursun Merve Alaylıoğlu Duygu Gezen-Ak Cedric Annweiler Dimitrios Skoutas Dimosthenis Evangelidis Dimitrios Kiortsis |
| author_facet | Spyridon N. Karras Erdinç Dursun Merve Alaylıoğlu Duygu Gezen-Ak Cedric Annweiler Dimitrios Skoutas Dimosthenis Evangelidis Dimitrios Kiortsis |
| author_sort | Spyridon N. Karras |
| collection | DOAJ |
| description | Vitamin D receptor (VDR) polymorphisms have been associated with a plethora of adverse pregnancy and offspring outcomes. The aim of this study was to evaluate the combined effect of maternal and neonatal VDR polymorphisms (ApaI, TaqI, BsmI, FokI, Tru9I) and different maternal and neonatal 25(OH)D cut-offs on neonatal birth anthropometry. This cross-sectional study included data and samples from a cohort of mother–child pairs at birth. A detailed neonatal anthropometry analysis at birth was also conducted. Different 25(OH)D cut-offs for neonates and mothers were included, according to their vitamin D status at birth: for neonates, cut-offs of [25(OH)D ≤ 25 and > 25 nmol/L] and [25(OH)D ≤ 50 nmol/L] were adopted, whereas for mothers, a 25(OH)D cut-off of [25(OH)D ≤ 50 and > 50 nmol/L)] was investigated. Following this classification, maternal and neonatal VDR polymorphisms were evaluated to investigate the potential different effects of different neonatal and maternal 25(OH)D cut-offs on neonatal birth anthropometry. A total of 69 maternal-neonatal dyads were included in final analysis. Weight, neck rump length, chest circumference, abdominal circumference, abdominal circumference (iliac), high thigh circumference, middle thigh circumference, lower arm radial circumference, and lower leg calf circumference of neonates who had the TAQl SNP TT genotype and maternal 25(OH)D < 50 nmol/L were significantly higher than that of neonates who had the Tt or tt genotypes (<i>p</i> = 0.001, H<i>g</i> = 1.341, <i>p</i> = 0.036, H<i>g</i> = 0.976, <i>p</i> = 0.004, H<i>g</i> = 1.381, <i>p</i> = 0.001, H<i>g</i> = 1.554, <i>p</i> = 0.001, H<i>g</i> = 1.351, <i>p</i> = 0.028, H<i>g</i> = 0.918, <i>p</i> = 0.008, H<i>g</i> = 1.090, <i>p</i> = 0.002, H<i>g</i> = 1.217, and <i>p</i> = 0.020, H<i>g</i> = 1.263, respectively). Skin fold high anterior was significantly lower in neonates who had the BSMI SNP BB genotype compared to that of neonates with Bb or bb genotypes (<i>p</i> = 0.041, H<i>g</i> = 0.950), whereas neck rump length was significantly higher in neonates who had the FOKI SNP FF genotype compared to that of neonates who had Ff or ff genotypes (<i>p</i> = 0.042, H<i>g</i> = 1.228). Regarding neonatal VDR polymorphisms and cut-offs, the abdominal circumference (cm) of neonates who had the TAQI SNP TT genotype and 25(OH)D < 25 nmol/L were significantly higher than that of neonates who had the Tt or tt genotypes (<i>p</i> = 0.038, H<i>g</i> = 1.138). In conclusion, these results indicate that the maternal TAQI VDR polymorphism significantly affected neonatal birth anthropometry when maternal 25(OH) concentrations were <50 nmol/L, but not for a higher cut-off of >50 nmol/L, whereas this effect is minimally evident in the presence of neonatal TAQI polymorphism with neonatal 25(OH)D values <25 nmol/L. The implication of these findings could be incorporated in daily clinical practice by targeting a maternal 25(OH)D cut-off >50 nmol/L, which could be protective against any effect of genetic VDR variance polymorphism on birth anthropometry. |
| first_indexed | 2024-03-09T03:18:33Z |
| format | Article |
| id | doaj.art-0cac8fb9e18b48a98a151a327db33664 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T03:18:33Z |
| publishDate | 2021-01-01 |
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| series | Nutrients |
| spelling | doaj.art-0cac8fb9e18b48a98a151a327db336642023-12-03T15:13:02ZengMDPI AGNutrients2072-66432021-01-0113244310.3390/nu13020443Diverse Effects of Combinations of Maternal-Neonatal VDR Polymorphisms and 25-Hydroxyvitamin D Concentrations on Neonatal Birth Anthropometry: Functional Phenocopy Variability Dependence, Highlights the Need for Targeted Maternal 25-Hydroxyvitamin D Cut-Offs during PregnancySpyridon N. Karras0Erdinç Dursun1Merve Alaylıoğlu2Duygu Gezen-Ak3Cedric Annweiler4Dimitrios Skoutas5Dimosthenis Evangelidis6Dimitrios Kiortsis7National Scholarship Foundation, 55535 Thessaloniki, GreeceBrain and Neurodegenerative Disorders Research Laboratories, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34381 Istanbul, TurkeyBrain and Neurodegenerative Disorders Research Laboratories, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34381 Istanbul, TurkeyBrain and Neurodegenerative Disorders Research Laboratories, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34381 Istanbul, TurkeyDivision of Geriatric Medicine, Department of Neuroscience, Angers University Hospital, 49035 Angers, FranceSarafianos General Private Hospital, 54631 Thessaloniki, GreeceΕpsom and St Helier University Hospital NHS, London SM5 1AA, UKDepartment of Nuclear Medicine, University of Ioannina, 45110 Ioannina, GreeceVitamin D receptor (VDR) polymorphisms have been associated with a plethora of adverse pregnancy and offspring outcomes. The aim of this study was to evaluate the combined effect of maternal and neonatal VDR polymorphisms (ApaI, TaqI, BsmI, FokI, Tru9I) and different maternal and neonatal 25(OH)D cut-offs on neonatal birth anthropometry. This cross-sectional study included data and samples from a cohort of mother–child pairs at birth. A detailed neonatal anthropometry analysis at birth was also conducted. Different 25(OH)D cut-offs for neonates and mothers were included, according to their vitamin D status at birth: for neonates, cut-offs of [25(OH)D ≤ 25 and > 25 nmol/L] and [25(OH)D ≤ 50 nmol/L] were adopted, whereas for mothers, a 25(OH)D cut-off of [25(OH)D ≤ 50 and > 50 nmol/L)] was investigated. Following this classification, maternal and neonatal VDR polymorphisms were evaluated to investigate the potential different effects of different neonatal and maternal 25(OH)D cut-offs on neonatal birth anthropometry. A total of 69 maternal-neonatal dyads were included in final analysis. Weight, neck rump length, chest circumference, abdominal circumference, abdominal circumference (iliac), high thigh circumference, middle thigh circumference, lower arm radial circumference, and lower leg calf circumference of neonates who had the TAQl SNP TT genotype and maternal 25(OH)D < 50 nmol/L were significantly higher than that of neonates who had the Tt or tt genotypes (<i>p</i> = 0.001, H<i>g</i> = 1.341, <i>p</i> = 0.036, H<i>g</i> = 0.976, <i>p</i> = 0.004, H<i>g</i> = 1.381, <i>p</i> = 0.001, H<i>g</i> = 1.554, <i>p</i> = 0.001, H<i>g</i> = 1.351, <i>p</i> = 0.028, H<i>g</i> = 0.918, <i>p</i> = 0.008, H<i>g</i> = 1.090, <i>p</i> = 0.002, H<i>g</i> = 1.217, and <i>p</i> = 0.020, H<i>g</i> = 1.263, respectively). Skin fold high anterior was significantly lower in neonates who had the BSMI SNP BB genotype compared to that of neonates with Bb or bb genotypes (<i>p</i> = 0.041, H<i>g</i> = 0.950), whereas neck rump length was significantly higher in neonates who had the FOKI SNP FF genotype compared to that of neonates who had Ff or ff genotypes (<i>p</i> = 0.042, H<i>g</i> = 1.228). Regarding neonatal VDR polymorphisms and cut-offs, the abdominal circumference (cm) of neonates who had the TAQI SNP TT genotype and 25(OH)D < 25 nmol/L were significantly higher than that of neonates who had the Tt or tt genotypes (<i>p</i> = 0.038, H<i>g</i> = 1.138). In conclusion, these results indicate that the maternal TAQI VDR polymorphism significantly affected neonatal birth anthropometry when maternal 25(OH) concentrations were <50 nmol/L, but not for a higher cut-off of >50 nmol/L, whereas this effect is minimally evident in the presence of neonatal TAQI polymorphism with neonatal 25(OH)D values <25 nmol/L. The implication of these findings could be incorporated in daily clinical practice by targeting a maternal 25(OH)D cut-off >50 nmol/L, which could be protective against any effect of genetic VDR variance polymorphism on birth anthropometry.https://www.mdpi.com/2072-6643/13/2/443vitamin Dpregnancyneonatal healthpolymorphismbirth anthropometry |
| spellingShingle | Spyridon N. Karras Erdinç Dursun Merve Alaylıoğlu Duygu Gezen-Ak Cedric Annweiler Dimitrios Skoutas Dimosthenis Evangelidis Dimitrios Kiortsis Diverse Effects of Combinations of Maternal-Neonatal VDR Polymorphisms and 25-Hydroxyvitamin D Concentrations on Neonatal Birth Anthropometry: Functional Phenocopy Variability Dependence, Highlights the Need for Targeted Maternal 25-Hydroxyvitamin D Cut-Offs during Pregnancy Nutrients vitamin D pregnancy neonatal health polymorphism birth anthropometry |
| title | Diverse Effects of Combinations of Maternal-Neonatal VDR Polymorphisms and 25-Hydroxyvitamin D Concentrations on Neonatal Birth Anthropometry: Functional Phenocopy Variability Dependence, Highlights the Need for Targeted Maternal 25-Hydroxyvitamin D Cut-Offs during Pregnancy |
| title_full | Diverse Effects of Combinations of Maternal-Neonatal VDR Polymorphisms and 25-Hydroxyvitamin D Concentrations on Neonatal Birth Anthropometry: Functional Phenocopy Variability Dependence, Highlights the Need for Targeted Maternal 25-Hydroxyvitamin D Cut-Offs during Pregnancy |
| title_fullStr | Diverse Effects of Combinations of Maternal-Neonatal VDR Polymorphisms and 25-Hydroxyvitamin D Concentrations on Neonatal Birth Anthropometry: Functional Phenocopy Variability Dependence, Highlights the Need for Targeted Maternal 25-Hydroxyvitamin D Cut-Offs during Pregnancy |
| title_full_unstemmed | Diverse Effects of Combinations of Maternal-Neonatal VDR Polymorphisms and 25-Hydroxyvitamin D Concentrations on Neonatal Birth Anthropometry: Functional Phenocopy Variability Dependence, Highlights the Need for Targeted Maternal 25-Hydroxyvitamin D Cut-Offs during Pregnancy |
| title_short | Diverse Effects of Combinations of Maternal-Neonatal VDR Polymorphisms and 25-Hydroxyvitamin D Concentrations on Neonatal Birth Anthropometry: Functional Phenocopy Variability Dependence, Highlights the Need for Targeted Maternal 25-Hydroxyvitamin D Cut-Offs during Pregnancy |
| title_sort | diverse effects of combinations of maternal neonatal vdr polymorphisms and 25 hydroxyvitamin d concentrations on neonatal birth anthropometry functional phenocopy variability dependence highlights the need for targeted maternal 25 hydroxyvitamin d cut offs during pregnancy |
| topic | vitamin D pregnancy neonatal health polymorphism birth anthropometry |
| url | https://www.mdpi.com/2072-6643/13/2/443 |
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