Natural Killer T Cells (NKT cells) Functions in Malignancies
CD1d-restricted natural killer (NKT) cells are unique innate like T lymphocyte that recognize glycolipid antigens. Two major NKT cell subsets, type I and type II, are different in their TCR repertoire and ligand specificity. Up on activation, NKT cells mediated strong and rapid responses through the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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West Asia Organization for Cancer Prevention
2018-11-01
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| Series: | Asian Pacific Journal of Cancer Biology |
| Subjects: | |
| Online Access: | http://www.waocp.com/journal/index.php/apjcb/article/view/238 |
| _version_ | 1827370303544623104 |
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| author | Sima Balouchi-Anaraki Marzie Nourozian |
| author_facet | Sima Balouchi-Anaraki Marzie Nourozian |
| author_sort | Sima Balouchi-Anaraki |
| collection | DOAJ |
| description | CD1d-restricted natural killer (NKT) cells are unique innate like T lymphocyte that recognize glycolipid antigens. Two major NKT cell subsets, type I and type II, are different in their TCR repertoire and ligand specificity. Up on activation, NKT cells mediated strong and rapid responses through their ability to rapidly produce a large amount of both pro- and anti-inflammatory cytokines. Despite being a small population of αβ T lymphocytes, they can bridge the innate and adaptive arm of immune system through interaction with other immune components. These two subsets of NKT cells play critical apposite roles in anti-tumor immunity. This review focuses on the progress made in understanding the role of NKT cells in tumor immunity and how their activities can be useful in immunotherapeutic strategies. |
| first_indexed | 2024-03-08T10:13:17Z |
| format | Article |
| id | doaj.art-0cad999fb56740d4ac663aee67226e93 |
| institution | Directory Open Access Journal |
| issn | 2538-4635 |
| language | English |
| last_indexed | 2024-03-08T10:13:17Z |
| publishDate | 2018-11-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Biology |
| spelling | doaj.art-0cad999fb56740d4ac663aee67226e932024-01-29T05:58:06ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Biology2538-46352018-11-013310.31557/apjcb.2018.3.3.71-77238Natural Killer T Cells (NKT cells) Functions in MalignanciesSima Balouchi-Anaraki0Marzie Nourozian1Shiraz Institute for Cancer Research. Shiraz University of Medical Sciences Shiraz IranShiraz Institute for Cancer Research. Shiraz University of Medical Sciences Shiraz IranCD1d-restricted natural killer (NKT) cells are unique innate like T lymphocyte that recognize glycolipid antigens. Two major NKT cell subsets, type I and type II, are different in their TCR repertoire and ligand specificity. Up on activation, NKT cells mediated strong and rapid responses through their ability to rapidly produce a large amount of both pro- and anti-inflammatory cytokines. Despite being a small population of αβ T lymphocytes, they can bridge the innate and adaptive arm of immune system through interaction with other immune components. These two subsets of NKT cells play critical apposite roles in anti-tumor immunity. This review focuses on the progress made in understanding the role of NKT cells in tumor immunity and how their activities can be useful in immunotherapeutic strategies.http://www.waocp.com/journal/index.php/apjcb/article/view/238cd1d-restricted natural killer- αβ t lymphocytes- anti-tumor- malignanceies |
| spellingShingle | Sima Balouchi-Anaraki Marzie Nourozian Natural Killer T Cells (NKT cells) Functions in Malignancies Asian Pacific Journal of Cancer Biology cd1d-restricted natural killer- αβ t lymphocytes- anti-tumor- malignanceies |
| title | Natural Killer T Cells (NKT cells) Functions in Malignancies |
| title_full | Natural Killer T Cells (NKT cells) Functions in Malignancies |
| title_fullStr | Natural Killer T Cells (NKT cells) Functions in Malignancies |
| title_full_unstemmed | Natural Killer T Cells (NKT cells) Functions in Malignancies |
| title_short | Natural Killer T Cells (NKT cells) Functions in Malignancies |
| title_sort | natural killer t cells nkt cells functions in malignancies |
| topic | cd1d-restricted natural killer- αβ t lymphocytes- anti-tumor- malignanceies |
| url | http://www.waocp.com/journal/index.php/apjcb/article/view/238 |
| work_keys_str_mv | AT simabalouchianaraki naturalkillertcellsnktcellsfunctionsinmalignancies AT marzienourozian naturalkillertcellsnktcellsfunctionsinmalignancies |