Subacute Combined Degeneration of spinal cord with megaloblastic anemia secondary to vitamin B12 deficiency in a 17-year female
Sub acute combined degeneration of spinal cord (SCD), a treatable non-compressive myelopathy, is a rare cause of demyelination of the dorsal and lateral columns of the spinal cord. Megaloblastic anemia is a disorder caused by impaired DNA synthesis and is characterised by a distinctive abnormali...
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| Format: | Article |
| Language: | English |
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Prathima Institute of Medical Sciences
2017-04-01
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| Series: | Perspectives In Medical Research |
| Subjects: | |
| Online Access: | http://www.pimr.org.in/Majed-momin.PDF |
| _version_ | 1797462430210588672 |
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| author | Majed B Momin1 , Sandeep S2 . Anamika Aluri3 , Suhela R |
| author_facet | Majed B Momin1 , Sandeep S2 . Anamika Aluri3 , Suhela R |
| author_sort | Majed B Momin1 , Sandeep S2 . Anamika Aluri3 , Suhela R |
| collection | DOAJ |
| description | Sub acute combined degeneration of spinal cord (SCD),
a treatable non-compressive myelopathy, is a rare cause of
demyelination of the dorsal and lateral columns of the spinal
cord. Megaloblastic anemia is a disorder caused by impaired
DNA synthesis and is characterised by a distinctive abnormality
in the hematopoietic precursors in the bone marrow in which
the maturation of the nucleus is delayed relative to that of the
cytoplasm.Both this condition are complication of vitamin B12
deficiency, which is reversible if diagnosed and treated early.
We present a case of a 17- year-female patient with symptoms
of tingling and numbness in both lower limbs and MRI showing
relative thinning of dorsal cord from D4 to D10 level with areas
of hyperintensity along posterior surface.A diagnosis of sub
acute combined degeneration of the spinal cord was
considered and confirmed by laboratory findings especially by
blood peripheral smear findings, RBCs indices,bone marrow
aspiration cytology and serum vitamin B12. The patient showed
complete recovery on B12 therapy. This case is interesting as
Vitamin B12 deficiency & neurological presentation in a 17-
year young female is uncommon. |
| first_indexed | 2024-03-09T17:36:25Z |
| format | Article |
| id | doaj.art-0caee368c1714636ae96f12718e23f24 |
| institution | Directory Open Access Journal |
| issn | 2348-1447 2348-229X |
| language | English |
| last_indexed | 2024-03-09T17:36:25Z |
| publishDate | 2017-04-01 |
| publisher | Prathima Institute of Medical Sciences |
| record_format | Article |
| series | Perspectives In Medical Research |
| spelling | doaj.art-0caee368c1714636ae96f12718e23f242023-11-24T11:52:41ZengPrathima Institute of Medical SciencesPerspectives In Medical Research2348-14472348-229X2017-04-01517880Subacute Combined Degeneration of spinal cord with megaloblastic anemia secondary to vitamin B12 deficiency in a 17-year femaleMajed B Momin1 , Sandeep S2 . Anamika Aluri3 , Suhela R0Yashoda HospitalSub acute combined degeneration of spinal cord (SCD), a treatable non-compressive myelopathy, is a rare cause of demyelination of the dorsal and lateral columns of the spinal cord. Megaloblastic anemia is a disorder caused by impaired DNA synthesis and is characterised by a distinctive abnormality in the hematopoietic precursors in the bone marrow in which the maturation of the nucleus is delayed relative to that of the cytoplasm.Both this condition are complication of vitamin B12 deficiency, which is reversible if diagnosed and treated early. We present a case of a 17- year-female patient with symptoms of tingling and numbness in both lower limbs and MRI showing relative thinning of dorsal cord from D4 to D10 level with areas of hyperintensity along posterior surface.A diagnosis of sub acute combined degeneration of the spinal cord was considered and confirmed by laboratory findings especially by blood peripheral smear findings, RBCs indices,bone marrow aspiration cytology and serum vitamin B12. The patient showed complete recovery on B12 therapy. This case is interesting as Vitamin B12 deficiency & neurological presentation in a 17- year young female is uncommon.http://www.pimr.org.in/Majed-momin.PDFscdmegaloblastic anemiavitamin b12 deficiency |
| spellingShingle | Majed B Momin1 , Sandeep S2 . Anamika Aluri3 , Suhela R Subacute Combined Degeneration of spinal cord with megaloblastic anemia secondary to vitamin B12 deficiency in a 17-year female Perspectives In Medical Research scd megaloblastic anemia vitamin b12 deficiency |
| title | Subacute Combined Degeneration of spinal cord with megaloblastic anemia secondary to vitamin B12 deficiency in a 17-year female |
| title_full | Subacute Combined Degeneration of spinal cord with megaloblastic anemia secondary to vitamin B12 deficiency in a 17-year female |
| title_fullStr | Subacute Combined Degeneration of spinal cord with megaloblastic anemia secondary to vitamin B12 deficiency in a 17-year female |
| title_full_unstemmed | Subacute Combined Degeneration of spinal cord with megaloblastic anemia secondary to vitamin B12 deficiency in a 17-year female |
| title_short | Subacute Combined Degeneration of spinal cord with megaloblastic anemia secondary to vitamin B12 deficiency in a 17-year female |
| title_sort | subacute combined degeneration of spinal cord with megaloblastic anemia secondary to vitamin b12 deficiency in a 17 year female |
| topic | scd megaloblastic anemia vitamin b12 deficiency |
| url | http://www.pimr.org.in/Majed-momin.PDF |
| work_keys_str_mv | AT majedbmomin1sandeeps2anamikaaluri3suhelar subacutecombineddegenerationofspinalcordwithmegaloblasticanemiasecondarytovitaminb12deficiencyina17yearfemale |