Nanomedicines Targeting Metabolism in the Tumor Microenvironment
Cancer cells reprogram their metabolism to meet their growing demand for bioenergy and biosynthesis. The metabolic profile of cancer cells usually includes dysregulation of main nutritional metabolic pathways and the production of metabolites, which leads to a tumor microenvironment (TME) having the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.943906/full |
| _version_ | 1811315695600795648 |
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| author | Mengdi Ren Xiaoqiang Zheng Huan Gao Aimin Jiang Yu Yao Wangxiao He |
| author_facet | Mengdi Ren Xiaoqiang Zheng Huan Gao Aimin Jiang Yu Yao Wangxiao He |
| author_sort | Mengdi Ren |
| collection | DOAJ |
| description | Cancer cells reprogram their metabolism to meet their growing demand for bioenergy and biosynthesis. The metabolic profile of cancer cells usually includes dysregulation of main nutritional metabolic pathways and the production of metabolites, which leads to a tumor microenvironment (TME) having the characteristics of acidity, hypoxic, and/or nutrient depletion. Therapies targeting metabolism have become an active and revolutionary research topic for anti-cancer drug development. The differential metabolic vulnerabilities between tumor cells and other cells within TME provide nanotechnology a therapeutic window of anti-cancer. In this review, we present the metabolic characteristics of intrinsic cancer cells and TME and summarize representative strategies of nanoparticles in metabolism-regulating anti-cancer therapy. Then, we put forward the challenges and opportunities of using nanoparticles in this emerging field. |
| first_indexed | 2024-04-13T11:35:52Z |
| format | Article |
| id | doaj.art-0caf483fa1b948c3ad6bb766b53905ab |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T11:35:52Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-0caf483fa1b948c3ad6bb766b53905ab2022-12-22T02:48:27ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-08-011010.3389/fbioe.2022.943906943906Nanomedicines Targeting Metabolism in the Tumor MicroenvironmentMengdi Ren0Xiaoqiang Zheng1Huan Gao2Aimin Jiang3Yu Yao4Wangxiao He5Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaInstitute for Stem Cell and Regenerative Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Talent Highland, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaCancer cells reprogram their metabolism to meet their growing demand for bioenergy and biosynthesis. The metabolic profile of cancer cells usually includes dysregulation of main nutritional metabolic pathways and the production of metabolites, which leads to a tumor microenvironment (TME) having the characteristics of acidity, hypoxic, and/or nutrient depletion. Therapies targeting metabolism have become an active and revolutionary research topic for anti-cancer drug development. The differential metabolic vulnerabilities between tumor cells and other cells within TME provide nanotechnology a therapeutic window of anti-cancer. In this review, we present the metabolic characteristics of intrinsic cancer cells and TME and summarize representative strategies of nanoparticles in metabolism-regulating anti-cancer therapy. Then, we put forward the challenges and opportunities of using nanoparticles in this emerging field.https://www.frontiersin.org/articles/10.3389/fbioe.2022.943906/fullmetabolic reprogramingtumor microenvironmentnanomedicinemetabolismcancer treatment |
| spellingShingle | Mengdi Ren Xiaoqiang Zheng Huan Gao Aimin Jiang Yu Yao Wangxiao He Nanomedicines Targeting Metabolism in the Tumor Microenvironment Frontiers in Bioengineering and Biotechnology metabolic reprograming tumor microenvironment nanomedicine metabolism cancer treatment |
| title | Nanomedicines Targeting Metabolism in the Tumor Microenvironment |
| title_full | Nanomedicines Targeting Metabolism in the Tumor Microenvironment |
| title_fullStr | Nanomedicines Targeting Metabolism in the Tumor Microenvironment |
| title_full_unstemmed | Nanomedicines Targeting Metabolism in the Tumor Microenvironment |
| title_short | Nanomedicines Targeting Metabolism in the Tumor Microenvironment |
| title_sort | nanomedicines targeting metabolism in the tumor microenvironment |
| topic | metabolic reprograming tumor microenvironment nanomedicine metabolism cancer treatment |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.943906/full |
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