Behavioral and transcriptomic effects of the cancer treatment tamoxifen in mice

Behavioral and transcriptomic effects of the cancer treatment tamoxifen in mice

IntroductionTamoxifen is a common treatment for estrogen receptor-positive breast cancer. While tamoxifen treatment is generally accepted as safe, there are concerns about adverse effects on cognition.MethodsWe used a mouse model of chronic tamoxifen exposure to examine the effects of tamoxifen on t...

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Bibliographic Details
Main Authors: Elena Galvano, Harshul Pandit, Jordy Sepulveda, Christi Anne S. Ng, Melanie K. Becher, Jeanne S. Mandelblatt, Kathleen Van Dyk, G. William Rebeck
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Neuroscience
Subjects:
tamoxifen
chemotherapy
blood-brain barrier
transcriptomic (RNA-seq)
behavior
mouse model
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1068334/full

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