Enhanced Inflammatory Status in Patients with Simple Central Obesity in Absence of Metabolic Syndrome
Introduction: Abdominal obesity is associated with cardiovascular risk factors. Metabolic Syndrome (MS) describes a constellation of metabolic abnormalities, including abdominal obesity. However, there is limited data on the comparison of inflammatory biomarkers in centrally obese subjects without M...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2019-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/12695/40006_CE[Ra1]_F(SL)_PF1(AJ_SL)_PN(SL).pdf |
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| author | Muhamed T Osman Hanis Saimin Nadzimah Mohd Nasir Suraya Abdul Razak Zaliha Ismail Hapizah Mohd Nawawi |
| author_facet | Muhamed T Osman Hanis Saimin Nadzimah Mohd Nasir Suraya Abdul Razak Zaliha Ismail Hapizah Mohd Nawawi |
| author_sort | Muhamed T Osman |
| collection | DOAJ |
| description | Introduction: Abdominal obesity is associated with cardiovascular risk factors. Metabolic Syndrome (MS) describes a constellation of metabolic abnormalities, including abdominal obesity. However, there is limited data on the comparison of inflammatory biomarkers in centrally obese subjects without MS. Aim: To examine the biomarkers of inflammation in subjects with MS, central obesity without MS, and normal controls. Materials and Methods: This was a cross-sectional study involving 501 subjects categorised into MS, central obesity without MS (COBXMS), and healthy controls (NC). Soluble biomarkers of inflammation {high sensitivity C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Soluble Intercellular Adhesion Molecule-1 (sICAM-1), Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) and soluble E-selectin} were measured. Results: MS had significant elevation in all biomarkers, while COBXMS had higher concentrations of all biomarkers except sVCAM-1 compared to NC. COBXMS had elevated hs-CRP, IL-6 and sICAM-1 comparable with MS. Obesity categories of subjects (MS, COBXMS or NC) were associated with quartiles of each biomarker concentration (p<0.001). Waist circumference was significantly correlated and associated with all biomarkers, and was the independent predictor for sICAM-1 and E-selectin after correcting for confounding factors. Conclusion: Centrally obese subjects without MS have elevated concentration of inflammatory biomarkers comparable to those with MS, suggesting the pivotal role of simple central obesity even in the absence of MS in inflammation and possible enhanced atherogenesis. |
| first_indexed | 2024-12-20T02:41:02Z |
| format | Article |
| id | doaj.art-0caf71d40f6f4ee7945f8f65847b03dc |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-20T02:41:02Z |
| publishDate | 2019-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-0caf71d40f6f4ee7945f8f65847b03dc2022-12-21T19:56:19ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2019-03-01133EC09EC1410.7860/JCDR/2019/40006.12695Enhanced Inflammatory Status in Patients with Simple Central Obesity in Absence of Metabolic SyndromeMuhamed T Osman0Hanis Saimin1Nadzimah Mohd Nasir2Suraya Abdul Razak3Zaliha Ismail4Hapizah Mohd Nawawi5Associate Professor, Department of Pathology, Faculty of Medicine, Universiti Pertahanan Nasional Malaysia, Singai Besi, Kuala Lumpur, Malaysia.Researcher, Department of Pathology, Institute of Pathology, Laboratory and Forensic Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.Department of Community Medicine, Institute of Pathology, Laboratory and Forensic Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.Professor, Department of Pathology, Institute of Pathology, Laboratory and Forensic Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.Introduction: Abdominal obesity is associated with cardiovascular risk factors. Metabolic Syndrome (MS) describes a constellation of metabolic abnormalities, including abdominal obesity. However, there is limited data on the comparison of inflammatory biomarkers in centrally obese subjects without MS. Aim: To examine the biomarkers of inflammation in subjects with MS, central obesity without MS, and normal controls. Materials and Methods: This was a cross-sectional study involving 501 subjects categorised into MS, central obesity without MS (COBXMS), and healthy controls (NC). Soluble biomarkers of inflammation {high sensitivity C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Soluble Intercellular Adhesion Molecule-1 (sICAM-1), Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) and soluble E-selectin} were measured. Results: MS had significant elevation in all biomarkers, while COBXMS had higher concentrations of all biomarkers except sVCAM-1 compared to NC. COBXMS had elevated hs-CRP, IL-6 and sICAM-1 comparable with MS. Obesity categories of subjects (MS, COBXMS or NC) were associated with quartiles of each biomarker concentration (p<0.001). Waist circumference was significantly correlated and associated with all biomarkers, and was the independent predictor for sICAM-1 and E-selectin after correcting for confounding factors. Conclusion: Centrally obese subjects without MS have elevated concentration of inflammatory biomarkers comparable to those with MS, suggesting the pivotal role of simple central obesity even in the absence of MS in inflammation and possible enhanced atherogenesis.https://jcdr.net/articles/PDF/12695/40006_CE[Ra1]_F(SL)_PF1(AJ_SL)_PN(SL).pdfe-selectininflammationsvcam-1sicam-1 |
| spellingShingle | Muhamed T Osman Hanis Saimin Nadzimah Mohd Nasir Suraya Abdul Razak Zaliha Ismail Hapizah Mohd Nawawi Enhanced Inflammatory Status in Patients with Simple Central Obesity in Absence of Metabolic Syndrome Journal of Clinical and Diagnostic Research e-selectin inflammation svcam-1 sicam-1 |
| title | Enhanced Inflammatory Status in Patients with Simple Central Obesity in Absence of Metabolic Syndrome |
| title_full | Enhanced Inflammatory Status in Patients with Simple Central Obesity in Absence of Metabolic Syndrome |
| title_fullStr | Enhanced Inflammatory Status in Patients with Simple Central Obesity in Absence of Metabolic Syndrome |
| title_full_unstemmed | Enhanced Inflammatory Status in Patients with Simple Central Obesity in Absence of Metabolic Syndrome |
| title_short | Enhanced Inflammatory Status in Patients with Simple Central Obesity in Absence of Metabolic Syndrome |
| title_sort | enhanced inflammatory status in patients with simple central obesity in absence of metabolic syndrome |
| topic | e-selectin inflammation svcam-1 sicam-1 |
| url | https://jcdr.net/articles/PDF/12695/40006_CE[Ra1]_F(SL)_PF1(AJ_SL)_PN(SL).pdf |
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