Renal function in patients receiving long-term warfarin therapy: A five-year prospective follow-up
Aim. To investigate the prognostic value of renal function and to estimate glomerular filtration rate (GFR) changes during a 5-year follow-up of patients receiving warfarin therapy. Subjects and methods. 200 patients (124 men, 76 women) mainly from a group at high risk for thromboembolic events (mea...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2017-09-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32313/pdf |
| _version_ | 1828170717464625152 |
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| author | O A Zemlyanskaya E S Kropacheva A B Dobrovolsky E P Panchenko |
| author_facet | O A Zemlyanskaya E S Kropacheva A B Dobrovolsky E P Panchenko |
| author_sort | O A Zemlyanskaya |
| collection | DOAJ |
| description | Aim. To investigate the prognostic value of renal function and to estimate glomerular filtration rate (GFR) changes during a 5-year follow-up of patients receiving warfarin therapy. Subjects and methods. 200 patients (124 men, 76 women) mainly from a group at high risk for thromboembolic events (mean CHA2DS2-VASc scores, 3.25±1.89) were examined. The patients’ mean age was 62.3±9.4 years; the follow-up period was 5 years. 74% of the patients received warfarin monotherapy (international normalized ratio (INR) 2.0 to 3.0); 36% took vitamin K antagonists in combination with one or two antiplatelet agents. The CKD-EPI formula was used to estimate GFR in all the patients at baseline and throughout the investigation once a year. Results. GFR less than 70.9 ml/min/1.73 m2 was found to be a predictor of fatal and nonfatal thrombotic events. The decreased GFR was unassociated with the development of major and clinically relevant hemorrhagic complications within 5 years of warfarin therapy. The initial decline in renal function (GFR |
| first_indexed | 2024-04-12T03:14:56Z |
| format | Article |
| id | doaj.art-0cb035c1634842458b75c21605f5920e |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T03:14:56Z |
| publishDate | 2017-09-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-0cb035c1634842458b75c21605f5920e2022-12-22T03:50:08Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422017-09-01899788610.17116/terarkh201789978-8629313Renal function in patients receiving long-term warfarin therapy: A five-year prospective follow-upO A ZemlyanskayaE S KropachevaA B DobrovolskyE P PanchenkoAim. To investigate the prognostic value of renal function and to estimate glomerular filtration rate (GFR) changes during a 5-year follow-up of patients receiving warfarin therapy. Subjects and methods. 200 patients (124 men, 76 women) mainly from a group at high risk for thromboembolic events (mean CHA2DS2-VASc scores, 3.25±1.89) were examined. The patients’ mean age was 62.3±9.4 years; the follow-up period was 5 years. 74% of the patients received warfarin monotherapy (international normalized ratio (INR) 2.0 to 3.0); 36% took vitamin K antagonists in combination with one or two antiplatelet agents. The CKD-EPI formula was used to estimate GFR in all the patients at baseline and throughout the investigation once a year. Results. GFR less than 70.9 ml/min/1.73 m2 was found to be a predictor of fatal and nonfatal thrombotic events. The decreased GFR was unassociated with the development of major and clinically relevant hemorrhagic complications within 5 years of warfarin therapy. The initial decline in renal function (GFRhttps://ter-arkhiv.ru/0040-3660/article/viewFile/32313/pdfwarfarinchronic kidney diseaseglomerular filtration ratethromboembolic eventsbleedings |
| spellingShingle | O A Zemlyanskaya E S Kropacheva A B Dobrovolsky E P Panchenko Renal function in patients receiving long-term warfarin therapy: A five-year prospective follow-up Терапевтический архив warfarin chronic kidney disease glomerular filtration rate thromboembolic events bleedings |
| title | Renal function in patients receiving long-term warfarin therapy: A five-year prospective follow-up |
| title_full | Renal function in patients receiving long-term warfarin therapy: A five-year prospective follow-up |
| title_fullStr | Renal function in patients receiving long-term warfarin therapy: A five-year prospective follow-up |
| title_full_unstemmed | Renal function in patients receiving long-term warfarin therapy: A five-year prospective follow-up |
| title_short | Renal function in patients receiving long-term warfarin therapy: A five-year prospective follow-up |
| title_sort | renal function in patients receiving long term warfarin therapy a five year prospective follow up |
| topic | warfarin chronic kidney disease glomerular filtration rate thromboembolic events bleedings |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/32313/pdf |
| work_keys_str_mv | AT oazemlyanskaya renalfunctioninpatientsreceivinglongtermwarfarintherapyafiveyearprospectivefollowup AT eskropacheva renalfunctioninpatientsreceivinglongtermwarfarintherapyafiveyearprospectivefollowup AT abdobrovolsky renalfunctioninpatientsreceivinglongtermwarfarintherapyafiveyearprospectivefollowup AT eppanchenko renalfunctioninpatientsreceivinglongtermwarfarintherapyafiveyearprospectivefollowup |