Diffuse skin hyperpigmentation in CD30+ lymphoproliferation
CD30+ T-cell lymphoproliferative disorders (LD) comprise two main groups of diseases: CD30+ LD of the skin and systemic anaplastic large cell lymphoma (ALCL). The main feature of these disorders is the expression of CD30. We present a patient with an unusual clinical presentation of CD30+ lymphoprol...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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King Faisal Specialist Hospital and Research Centre
2012-05-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2012.318 |
| _version_ | 1818275187436552192 |
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| author | Zeljko Prka Cedna Tomasovic-Loncaric Vlatko Pejsa Branimir Nevajda Rajko Kusec |
| author_facet | Zeljko Prka Cedna Tomasovic-Loncaric Vlatko Pejsa Branimir Nevajda Rajko Kusec |
| author_sort | Zeljko Prka |
| collection | DOAJ |
| description | CD30+ T-cell lymphoproliferative disorders (LD) comprise two main groups of diseases: CD30+ LD of the skin and systemic anaplastic large cell lymphoma (ALCL). The main feature of these disorders is the expression of CD30. We present a patient with an unusual clinical presentation of CD30+ lymphoproliferative disease in a 54-year old Caucasian male who presented with generalized lymphadenopathy and pronounced skin hyperpigmentation. In the lymph nodes and skin, CD30+ lymphoproliferation (ALCL) was diagnosed. The Prussian blue staining identified that the pigment responsible for the skin color was hemosiderin. Chemotherapy was started but the patient's condition progressively worsened and he died a week after the first cycle. The complete color transformation of the entire skin due to hemosiderin accumulation is, to the best of our knowledge, the first reported observation in a CD30+ lymphoproliferation/ALCL patient. We speculate that hemosiderin-loaded macrophages resulted from the paraneoplastic process by some still unknown mechanism. |
| first_indexed | 2024-12-12T22:25:46Z |
| format | Article |
| id | doaj.art-0cb20d598d524d3bb563b9278512b72e |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-12-12T22:25:46Z |
| publishDate | 2012-05-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-0cb20d598d524d3bb563b9278512b72e2022-12-22T00:09:45ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662012-05-0132331832010.5144/0256-4947.2012.318asm-3-318Diffuse skin hyperpigmentation in CD30+ lymphoproliferationZeljko Prka0Cedna Tomasovic-Loncaric1Vlatko Pejsa2Branimir Nevajda3Rajko Kusec4From the Department of Internal Medicine, University Hospital Dubrava, Division of Hematology, Zagreb, CroatiaFrom the Department of Pathology, University Hospital Dubrava, Zagreb, CroatiaFrom the Department of Internal Medicine, University Hospital Dubrava, Division of Hematology, Zagreb, CroatiaFrom the Department of Internal Medicine, University Hospital Dubrava, Division of Hematology, Zagreb, CroatiaFrom the Department of Internal Medicine, University Hospital Dubrava, Division of Hematology, Zagreb, CroatiaCD30+ T-cell lymphoproliferative disorders (LD) comprise two main groups of diseases: CD30+ LD of the skin and systemic anaplastic large cell lymphoma (ALCL). The main feature of these disorders is the expression of CD30. We present a patient with an unusual clinical presentation of CD30+ lymphoproliferative disease in a 54-year old Caucasian male who presented with generalized lymphadenopathy and pronounced skin hyperpigmentation. In the lymph nodes and skin, CD30+ lymphoproliferation (ALCL) was diagnosed. The Prussian blue staining identified that the pigment responsible for the skin color was hemosiderin. Chemotherapy was started but the patient's condition progressively worsened and he died a week after the first cycle. The complete color transformation of the entire skin due to hemosiderin accumulation is, to the best of our knowledge, the first reported observation in a CD30+ lymphoproliferation/ALCL patient. We speculate that hemosiderin-loaded macrophages resulted from the paraneoplastic process by some still unknown mechanism.https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2012.318 |
| spellingShingle | Zeljko Prka Cedna Tomasovic-Loncaric Vlatko Pejsa Branimir Nevajda Rajko Kusec Diffuse skin hyperpigmentation in CD30+ lymphoproliferation Annals of Saudi Medicine |
| title | Diffuse skin hyperpigmentation in CD30+ lymphoproliferation |
| title_full | Diffuse skin hyperpigmentation in CD30+ lymphoproliferation |
| title_fullStr | Diffuse skin hyperpigmentation in CD30+ lymphoproliferation |
| title_full_unstemmed | Diffuse skin hyperpigmentation in CD30+ lymphoproliferation |
| title_short | Diffuse skin hyperpigmentation in CD30+ lymphoproliferation |
| title_sort | diffuse skin hyperpigmentation in cd30 lymphoproliferation |
| url | https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2012.318 |
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