Evolving Profile of HPV-Driven Oropharyngeal Squamous Cell Carcinoma in a National Cancer Institute in Italy: A 10-Year Retrospective Study
Globally, 30% of oropharyngeal carcinomas (OPSCC) are caused by Human Papillomavirus (HPV). Recently, increasing incidence trends for HPV-driven OPSCC have been reported in many countries and changes in the typical HPV-positive OPSCC patient have been recorded, with an increase in the median age and...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/8/10/1498 |
| _version_ | 1827705170260131840 |
|---|---|
| author | Maria Gabriella Donà Francesca Rollo Barbara Pichi Giuseppe Spriano Silvia Moretto Renato Covello Raul Pellini Maria Benevolo |
| author_facet | Maria Gabriella Donà Francesca Rollo Barbara Pichi Giuseppe Spriano Silvia Moretto Renato Covello Raul Pellini Maria Benevolo |
| author_sort | Maria Gabriella Donà |
| collection | DOAJ |
| description | Globally, 30% of oropharyngeal carcinomas (OPSCC) are caused by Human Papillomavirus (HPV). Recently, increasing incidence trends for HPV-driven OPSCC have been reported in many countries and changes in the typical HPV-positive OPSCC patient have been recorded, with an increase in the median age and diagnoses in women. We investigated the characteristics of the OPSCC patients attending an Italian Cancer Institute from 2010 to 2019 and assessed possible changes overtime of demographic, behavioral, and clinico-pathologic variables of HPV-driven OPSCC. Overall, 339 OPSCCs were evaluated. HPV-DNA and p16 positivity were 48.7% and 55.2%, respectively, with an HPV-driven fraction (i.e., HPV-DNA+/p16+) of 48.3%. We observed a significant increase overtime in the rate of HPV-associated cases (53.7% in 2015–2019 vs. 40.3% in 2010–2014, <i>p</i> = 0.019). The rate of HPV-driven cases was significantly higher among women, never smokers, patients with T1–T2 tumors, and with nodal involvement. A trend was also observed toward an increase in HPV-driven OPSCCs among patients >61 years, women, former smokers, and patients with no nodal involvement in 2015–2019. Our findings consolidate the observation that HPV-associated OPSCCs are also increasing in Italy. Moreover, they suggest that the profile of the HPV-driven OPSCC patient might be changing. |
| first_indexed | 2024-03-10T15:57:30Z |
| format | Article |
| id | doaj.art-0cb311a12a494dd3b2ba2d362a76a214 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T15:57:30Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-0cb311a12a494dd3b2ba2d362a76a2142023-11-20T15:29:20ZengMDPI AGMicroorganisms2076-26072020-09-01810149810.3390/microorganisms8101498Evolving Profile of HPV-Driven Oropharyngeal Squamous Cell Carcinoma in a National Cancer Institute in Italy: A 10-Year Retrospective StudyMaria Gabriella Donà0Francesca Rollo1Barbara Pichi2Giuseppe Spriano3Silvia Moretto4Renato Covello5Raul Pellini6Maria Benevolo7STI/HIV Unit, San Gallicano Dermatologic Institute IRCCS, Via Elio Chianesi 53, 00144 Rome, ItalyPathology Department, Regina Elena National Cancer Institute IRCCS, Via Elio Chianesi 53, 00144 Rome, ItalyOtolaryngology Head and Neck Surgery Department, Regina Elena National Cancer Institute IRCCS, Via Elio Chianesi 53, 00144 Rome, ItalyDepartment of Otolaryngology Head and Neck Surgery, Humanitas Clinical and Research Center—IRCCS, via Manzoni 56, 20089 Rozzano, Milan, ItalyOtolaryngology Head and Neck Surgery Department, Regina Elena National Cancer Institute IRCCS, Via Elio Chianesi 53, 00144 Rome, ItalyPathology Department, Regina Elena National Cancer Institute IRCCS, Via Elio Chianesi 53, 00144 Rome, ItalyOtolaryngology Head and Neck Surgery Department, Regina Elena National Cancer Institute IRCCS, Via Elio Chianesi 53, 00144 Rome, ItalyPathology Department, Regina Elena National Cancer Institute IRCCS, Via Elio Chianesi 53, 00144 Rome, ItalyGlobally, 30% of oropharyngeal carcinomas (OPSCC) are caused by Human Papillomavirus (HPV). Recently, increasing incidence trends for HPV-driven OPSCC have been reported in many countries and changes in the typical HPV-positive OPSCC patient have been recorded, with an increase in the median age and diagnoses in women. We investigated the characteristics of the OPSCC patients attending an Italian Cancer Institute from 2010 to 2019 and assessed possible changes overtime of demographic, behavioral, and clinico-pathologic variables of HPV-driven OPSCC. Overall, 339 OPSCCs were evaluated. HPV-DNA and p16 positivity were 48.7% and 55.2%, respectively, with an HPV-driven fraction (i.e., HPV-DNA+/p16+) of 48.3%. We observed a significant increase overtime in the rate of HPV-associated cases (53.7% in 2015–2019 vs. 40.3% in 2010–2014, <i>p</i> = 0.019). The rate of HPV-driven cases was significantly higher among women, never smokers, patients with T1–T2 tumors, and with nodal involvement. A trend was also observed toward an increase in HPV-driven OPSCCs among patients >61 years, women, former smokers, and patients with no nodal involvement in 2015–2019. Our findings consolidate the observation that HPV-associated OPSCCs are also increasing in Italy. Moreover, they suggest that the profile of the HPV-driven OPSCC patient might be changing.https://www.mdpi.com/2076-2607/8/10/1498neoplasmsoropharyngeal squamous cell carcinomahuman papillomavirusHPV-induced neoplasmsp16 |
| spellingShingle | Maria Gabriella Donà Francesca Rollo Barbara Pichi Giuseppe Spriano Silvia Moretto Renato Covello Raul Pellini Maria Benevolo Evolving Profile of HPV-Driven Oropharyngeal Squamous Cell Carcinoma in a National Cancer Institute in Italy: A 10-Year Retrospective Study Microorganisms neoplasms oropharyngeal squamous cell carcinoma human papillomavirus HPV-induced neoplasms p16 |
| title | Evolving Profile of HPV-Driven Oropharyngeal Squamous Cell Carcinoma in a National Cancer Institute in Italy: A 10-Year Retrospective Study |
| title_full | Evolving Profile of HPV-Driven Oropharyngeal Squamous Cell Carcinoma in a National Cancer Institute in Italy: A 10-Year Retrospective Study |
| title_fullStr | Evolving Profile of HPV-Driven Oropharyngeal Squamous Cell Carcinoma in a National Cancer Institute in Italy: A 10-Year Retrospective Study |
| title_full_unstemmed | Evolving Profile of HPV-Driven Oropharyngeal Squamous Cell Carcinoma in a National Cancer Institute in Italy: A 10-Year Retrospective Study |
| title_short | Evolving Profile of HPV-Driven Oropharyngeal Squamous Cell Carcinoma in a National Cancer Institute in Italy: A 10-Year Retrospective Study |
| title_sort | evolving profile of hpv driven oropharyngeal squamous cell carcinoma in a national cancer institute in italy a 10 year retrospective study |
| topic | neoplasms oropharyngeal squamous cell carcinoma human papillomavirus HPV-induced neoplasms p16 |
| url | https://www.mdpi.com/2076-2607/8/10/1498 |
| work_keys_str_mv | AT mariagabrielladona evolvingprofileofhpvdrivenoropharyngealsquamouscellcarcinomainanationalcancerinstituteinitalya10yearretrospectivestudy AT francescarollo evolvingprofileofhpvdrivenoropharyngealsquamouscellcarcinomainanationalcancerinstituteinitalya10yearretrospectivestudy AT barbarapichi evolvingprofileofhpvdrivenoropharyngealsquamouscellcarcinomainanationalcancerinstituteinitalya10yearretrospectivestudy AT giuseppespriano evolvingprofileofhpvdrivenoropharyngealsquamouscellcarcinomainanationalcancerinstituteinitalya10yearretrospectivestudy AT silviamoretto evolvingprofileofhpvdrivenoropharyngealsquamouscellcarcinomainanationalcancerinstituteinitalya10yearretrospectivestudy AT renatocovello evolvingprofileofhpvdrivenoropharyngealsquamouscellcarcinomainanationalcancerinstituteinitalya10yearretrospectivestudy AT raulpellini evolvingprofileofhpvdrivenoropharyngealsquamouscellcarcinomainanationalcancerinstituteinitalya10yearretrospectivestudy AT mariabenevolo evolvingprofileofhpvdrivenoropharyngealsquamouscellcarcinomainanationalcancerinstituteinitalya10yearretrospectivestudy |