TNF-Mediated Inhibition of Classical Swine Fever Virus Replication Is IRF1-, NF-κB- and JAK/STAT Signaling-Dependent

TNF-Mediated Inhibition of Classical Swine Fever Virus Replication Is IRF1-, NF-κB- and JAK/STAT Signaling-Dependent

The sera from pigs infected with virulent classical swine fever virus (CSFV) contain substantial amounts of tumor necrosis factor (TNF), a prototype proinflammatory cytokine with pleiotropic activities. TNF limits the replication of CSFV in cell culture. In order to investigate the signaling involve...

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Bibliographic Details
Main Authors: Matthias Liniger, Markus Gerber, Sandra Renzullo, Obdulio García-Nicolás, Nicolas Ruggli
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Viruses
Subjects:
pestivirus
classical swine fever virus
CSFV
TNF
type I IFN
JAK/STAT
Online Access:https://www.mdpi.com/1999-4915/13/10/2017

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