Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes

Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes

Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity in the mammary epithelium is reflected in extensive heterogeneity among bre...

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Bibliographic Details
Main Authors: Erik Knutsen, Saikat Das Sajib, Tonje Fiskaa, James Lorens, Thorarinn Gudjonsson, Gunhild M. Mælandsmo, Steinar Daae Johansen, Ole-Morten Seternes, Maria Perander
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Oncology
Subjects:
epithelial-mesenchymal transition
gene expression signature
breast cancer
RNA-Seq
EMT-transcription factors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1249895/full

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