Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis
ABSTRACTPredicting the long-term outcome of multiple sclerosis (MS) remains an important challenge to this day. As the gut microbiota is emerging as a potential player in MS, we investigated in this study whether gut microbial composition at baseline is related to long-term disability worsening in a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2180316 |
| _version_ | 1797236626235064320 |
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| author | Lindsay Devolder Ayla Pauwels Ann Van Remoortel Gwen Falony Sara Vieira-Silva Guy Nagels Jacques De Keyser Jeroen Raes Marie B. D’Hooghe |
| author_facet | Lindsay Devolder Ayla Pauwels Ann Van Remoortel Gwen Falony Sara Vieira-Silva Guy Nagels Jacques De Keyser Jeroen Raes Marie B. D’Hooghe |
| author_sort | Lindsay Devolder |
| collection | DOAJ |
| description | ABSTRACTPredicting the long-term outcome of multiple sclerosis (MS) remains an important challenge to this day. As the gut microbiota is emerging as a potential player in MS, we investigated in this study whether gut microbial composition at baseline is related to long-term disability worsening in a longitudinal cohort of 111 MS patients. Fecal samples and extensive host metadata were collected at baseline and 3 months post-baseline, with additional repeated neurological measurements performed over (median) 4.4 y. Worsening (with EDSS-Plus) occurred in 39/95 patients (outcome undetermined for 16 individuals). The inflammation-associated, dysbiotic Bacteroides 2 enterotype (Bact2) was detected at baseline in 43.6% of worsened patients, while only 16.1% of non-worsened patients harbored Bact2. This association was independent of identified confounders, and Bact2 was more strongly associated with EDSS-Plus than neurofilament light chain (NfL) plasma levels. Furthermore, using fecal sampling performed 3 months post-baseline, we observed Bact2 to be relatively stable, suggesting its potential use as a prognostic biomarker in MS clinical practice. |
| first_indexed | 2024-03-11T14:19:56Z |
| format | Article |
| id | doaj.art-0cb50beb12e04268950d8e69ef744bf2 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:06:50Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-0cb50beb12e04268950d8e69ef744bf22024-03-28T22:38:20ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2180316Gut microbiome composition is associated with long-term disability worsening in multiple sclerosisLindsay Devolder0Ayla Pauwels1Ann Van Remoortel2Gwen Falony3Sara Vieira-Silva4Guy Nagels5Jacques De Keyser6Jeroen Raes7Marie B. D’Hooghe8Laboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, BelgiumLaboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, BelgiumNational Multiple Sclerosis Center, Melsbroek, BelgiumLaboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, BelgiumLaboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, BelgiumCenter for Neurosciences, Vrije Universiteit Brussel, Jette, BelgiumCenter for Neurosciences, Vrije Universiteit Brussel, Jette, BelgiumLaboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, BelgiumCenter for Neurosciences, Vrije Universiteit Brussel, Jette, BelgiumABSTRACTPredicting the long-term outcome of multiple sclerosis (MS) remains an important challenge to this day. As the gut microbiota is emerging as a potential player in MS, we investigated in this study whether gut microbial composition at baseline is related to long-term disability worsening in a longitudinal cohort of 111 MS patients. Fecal samples and extensive host metadata were collected at baseline and 3 months post-baseline, with additional repeated neurological measurements performed over (median) 4.4 y. Worsening (with EDSS-Plus) occurred in 39/95 patients (outcome undetermined for 16 individuals). The inflammation-associated, dysbiotic Bacteroides 2 enterotype (Bact2) was detected at baseline in 43.6% of worsened patients, while only 16.1% of non-worsened patients harbored Bact2. This association was independent of identified confounders, and Bact2 was more strongly associated with EDSS-Plus than neurofilament light chain (NfL) plasma levels. Furthermore, using fecal sampling performed 3 months post-baseline, we observed Bact2 to be relatively stable, suggesting its potential use as a prognostic biomarker in MS clinical practice.https://www.tandfonline.com/doi/10.1080/19490976.2023.2180316multiple sclerosisgut microbiomeBacteroides 2neurofilament light chainEDSS-Pluslong-term disability worsening |
| spellingShingle | Lindsay Devolder Ayla Pauwels Ann Van Remoortel Gwen Falony Sara Vieira-Silva Guy Nagels Jacques De Keyser Jeroen Raes Marie B. D’Hooghe Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis Gut Microbes multiple sclerosis gut microbiome Bacteroides 2 neurofilament light chain EDSS-Plus long-term disability worsening |
| title | Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis |
| title_full | Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis |
| title_fullStr | Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis |
| title_full_unstemmed | Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis |
| title_short | Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis |
| title_sort | gut microbiome composition is associated with long term disability worsening in multiple sclerosis |
| topic | multiple sclerosis gut microbiome Bacteroides 2 neurofilament light chain EDSS-Plus long-term disability worsening |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2180316 |
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