Differential Impact of Acute and Chronic Stress on CA1 Spatial Coding and Gamma Oscillations
Chronic and acute stress differentially affect behavior as well as the structural integrity of the hippocampus, a key brain region involved in cognition and memory. However, it remains unclear if and how the facilitatory effects of acute stress on hippocampal information coding are disrupted as the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.710725/full |
| _version_ | 1818671998779260928 |
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| author | Anupratap Tomar Denis Polygalov Thomas J. McHugh |
| author_facet | Anupratap Tomar Denis Polygalov Thomas J. McHugh |
| author_sort | Anupratap Tomar |
| collection | DOAJ |
| description | Chronic and acute stress differentially affect behavior as well as the structural integrity of the hippocampus, a key brain region involved in cognition and memory. However, it remains unclear if and how the facilitatory effects of acute stress on hippocampal information coding are disrupted as the stress becomes chronic. To examine this, we compared the impact of acute and chronic stress on neural activity in the CA1 subregion of male mice subjected to a chronic immobilization stress (CIS) paradigm. We observed that following first exposure to stress (acute stress), the spatial information encoded in the hippocampus sharpened, and the neurons became increasingly tuned to the underlying theta oscillations in the local field potential (LFP). However, following repeated exposure to the same stress (chronic stress), spatial tuning was poorer and the power of both the slow-gamma (30–50 Hz) and fast-gamma (55–90 Hz) oscillations, which correlate with excitatory inputs into the region, decreased. These results support the idea that acute and chronic stress differentially affect neural computations carried out by hippocampal circuits and suggest that acute stress may improve cognitive processing. |
| first_indexed | 2024-12-17T07:32:55Z |
| format | Article |
| id | doaj.art-0cb6fd70520b422aad5f90035dc73267 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-17T07:32:55Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-0cb6fd70520b422aad5f90035dc732672022-12-21T21:58:25ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532021-07-011510.3389/fnbeh.2021.710725710725Differential Impact of Acute and Chronic Stress on CA1 Spatial Coding and Gamma OscillationsAnupratap TomarDenis PolygalovThomas J. McHughChronic and acute stress differentially affect behavior as well as the structural integrity of the hippocampus, a key brain region involved in cognition and memory. However, it remains unclear if and how the facilitatory effects of acute stress on hippocampal information coding are disrupted as the stress becomes chronic. To examine this, we compared the impact of acute and chronic stress on neural activity in the CA1 subregion of male mice subjected to a chronic immobilization stress (CIS) paradigm. We observed that following first exposure to stress (acute stress), the spatial information encoded in the hippocampus sharpened, and the neurons became increasingly tuned to the underlying theta oscillations in the local field potential (LFP). However, following repeated exposure to the same stress (chronic stress), spatial tuning was poorer and the power of both the slow-gamma (30–50 Hz) and fast-gamma (55–90 Hz) oscillations, which correlate with excitatory inputs into the region, decreased. These results support the idea that acute and chronic stress differentially affect neural computations carried out by hippocampal circuits and suggest that acute stress may improve cognitive processing.https://www.frontiersin.org/articles/10.3389/fnbeh.2021.710725/fullhippocampusacute stresschronic stressplace cellsthetaslow gamma |
| spellingShingle | Anupratap Tomar Denis Polygalov Thomas J. McHugh Differential Impact of Acute and Chronic Stress on CA1 Spatial Coding and Gamma Oscillations Frontiers in Behavioral Neuroscience hippocampus acute stress chronic stress place cells theta slow gamma |
| title | Differential Impact of Acute and Chronic Stress on CA1 Spatial Coding and Gamma Oscillations |
| title_full | Differential Impact of Acute and Chronic Stress on CA1 Spatial Coding and Gamma Oscillations |
| title_fullStr | Differential Impact of Acute and Chronic Stress on CA1 Spatial Coding and Gamma Oscillations |
| title_full_unstemmed | Differential Impact of Acute and Chronic Stress on CA1 Spatial Coding and Gamma Oscillations |
| title_short | Differential Impact of Acute and Chronic Stress on CA1 Spatial Coding and Gamma Oscillations |
| title_sort | differential impact of acute and chronic stress on ca1 spatial coding and gamma oscillations |
| topic | hippocampus acute stress chronic stress place cells theta slow gamma |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.710725/full |
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