Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in <i>Caenorhabditis elegans</i> and an SAMP8 Mice Model
The study of different natural products can provide a wealth of bioactive compounds, and more interestingly, their combination can exert a new strategy for several neurodegenerative diseases with major public health importance, such as Alzheimer’s disease (AD). Here, we investigated the synergistic...
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MDPI AG
2021-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/7/2411 |
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| author | Christian Griñán-Ferré Aina Bellver-Sanchis Mónica Olivares-Martín Oscar Bañuelos-Hortigüela Mercè Pallàs |
| author_facet | Christian Griñán-Ferré Aina Bellver-Sanchis Mónica Olivares-Martín Oscar Bañuelos-Hortigüela Mercè Pallàs |
| author_sort | Christian Griñán-Ferré |
| collection | DOAJ |
| description | The study of different natural products can provide a wealth of bioactive compounds, and more interestingly, their combination can exert a new strategy for several neurodegenerative diseases with major public health importance, such as Alzheimer’s disease (AD). Here, we investigated the synergistic neuroprotective effects of a mixed extract composed of docosahexaenoic acid, <i>Ginkgo biloba</i>, D-pinitol, and ursolic acid in several transgenic <i>Caenorhabditis elegans (C. elegans)</i> and a senescence-accelerated prone mice 8 (SAMP8) model. First, we found a significantly higher survival percentage in the <i>C. elegans</i> group treated with the natural product mixture compared to the single extract-treated groups. Likewise, we found a significantly increased lifespan in group of <i>C. elegans</i> treated with the natural product mixture compared to the other groups, suggesting synergistic effects. Remarkably, we determined a significant reduction in Aβ plaque accumulation in the group of <i>C. elegans</i> treated with the natural product mixture compared to the other groups, confirming synergy. Finally, we demonstrated better cognitive performance in the group treated with the natural product mixture in both AD models (neuronal Aβ <i>C. elegans</i> strain CL2355 and the SAMP8 mice model), confirming the molecular results and unraveling the synergist effects of this combination. Therefore, our results proved the potential of this new natural product mixture for AD therapeutic strategies. |
| first_indexed | 2024-03-10T09:29:10Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T09:29:10Z |
| publishDate | 2021-07-01 |
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| series | Nutrients |
| spelling | doaj.art-0cb95e6c699a4fb6a4049e347300f1ce2023-11-22T04:37:04ZengMDPI AGNutrients2072-66432021-07-01137241110.3390/nu13072411Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in <i>Caenorhabditis elegans</i> and an SAMP8 Mice ModelChristian Griñán-Ferré0Aina Bellver-Sanchis1Mónica Olivares-Martín2Oscar Bañuelos-Hortigüela3Mercè Pallàs4Pharmacology Section, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, University of Barcelona (NeuroUB), Av. Joan XXIII 27-31, 08028 Barcelona, SpainPharmacology Section, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, University of Barcelona (NeuroUB), Av. Joan XXIII 27-31, 08028 Barcelona, SpainR&D Department, Biosearch S.A. Camino de Purchil 66, 18004 Granada, SpainR&D Department, Biosearch S.A. Camino de Purchil 66, 18004 Granada, SpainPharmacology Section, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, University of Barcelona (NeuroUB), Av. Joan XXIII 27-31, 08028 Barcelona, SpainThe study of different natural products can provide a wealth of bioactive compounds, and more interestingly, their combination can exert a new strategy for several neurodegenerative diseases with major public health importance, such as Alzheimer’s disease (AD). Here, we investigated the synergistic neuroprotective effects of a mixed extract composed of docosahexaenoic acid, <i>Ginkgo biloba</i>, D-pinitol, and ursolic acid in several transgenic <i>Caenorhabditis elegans (C. elegans)</i> and a senescence-accelerated prone mice 8 (SAMP8) model. First, we found a significantly higher survival percentage in the <i>C. elegans</i> group treated with the natural product mixture compared to the single extract-treated groups. Likewise, we found a significantly increased lifespan in group of <i>C. elegans</i> treated with the natural product mixture compared to the other groups, suggesting synergistic effects. Remarkably, we determined a significant reduction in Aβ plaque accumulation in the group of <i>C. elegans</i> treated with the natural product mixture compared to the other groups, confirming synergy. Finally, we demonstrated better cognitive performance in the group treated with the natural product mixture in both AD models (neuronal Aβ <i>C. elegans</i> strain CL2355 and the SAMP8 mice model), confirming the molecular results and unraveling the synergist effects of this combination. Therefore, our results proved the potential of this new natural product mixture for AD therapeutic strategies.https://www.mdpi.com/2072-6643/13/7/2411agingAD hallmarksAlzheimer’s diseasenutritional interventionnatural extracts<i>C. elegans</i> |
| spellingShingle | Christian Griñán-Ferré Aina Bellver-Sanchis Mónica Olivares-Martín Oscar Bañuelos-Hortigüela Mercè Pallàs Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in <i>Caenorhabditis elegans</i> and an SAMP8 Mice Model Nutrients aging AD hallmarks Alzheimer’s disease nutritional intervention natural extracts <i>C. elegans</i> |
| title | Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in <i>Caenorhabditis elegans</i> and an SAMP8 Mice Model |
| title_full | Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in <i>Caenorhabditis elegans</i> and an SAMP8 Mice Model |
| title_fullStr | Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in <i>Caenorhabditis elegans</i> and an SAMP8 Mice Model |
| title_full_unstemmed | Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in <i>Caenorhabditis elegans</i> and an SAMP8 Mice Model |
| title_short | Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in <i>Caenorhabditis elegans</i> and an SAMP8 Mice Model |
| title_sort | synergistic neuroprotective effects of a natural product mixture against ad hallmarks and cognitive decline in i caenorhabditis elegans i and an samp8 mice model |
| topic | aging AD hallmarks Alzheimer’s disease nutritional intervention natural extracts <i>C. elegans</i> |
| url | https://www.mdpi.com/2072-6643/13/7/2411 |
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