<i>Codium fragile</i> Ameliorates High-Fat Diet-Induced Metabolism by Modulating the Gut Microbiota in Mice
<i>Codium fragile</i> (CF) is a functional seaweed food that has been used for its health effects, including immunostimulatory, anti-inflammatory, anti-obesity and anti-cancer activities, but the effect of CF extracts on obesity via regulation of intestinal microflora is still unknown. T...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/6/1848 |
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| author | Jungman Kim Jae Ho Choi Taehwan Oh Byungjae Ahn Tatsuya Unno |
| author_facet | Jungman Kim Jae Ho Choi Taehwan Oh Byungjae Ahn Tatsuya Unno |
| author_sort | Jungman Kim |
| collection | DOAJ |
| description | <i>Codium fragile</i> (CF) is a functional seaweed food that has been used for its health effects, including immunostimulatory, anti-inflammatory, anti-obesity and anti-cancer activities, but the effect of CF extracts on obesity via regulation of intestinal microflora is still unknown. This study investigated anti-obesity effects of CF extracts on gut microbiota of diet-induced obese mice. C57BL/6 mice fed a high-fat (HF) diet were given CF extracts intragastrically for 12 weeks. CF extracts significantly decreased animal body weight and the size of adipocytes, while reducing serum levels of cholesterol and glucose. In addition, CF extracts significantly shifted the gut microbiota of mice by increasing the abundance of Bacteroidetes and decreasing the abundance of Verrucomicrobia species, in which the portion of beneficial bacteria (i.e., Ruminococcaceae, Lachnospiraceae and <i>Acetatifactor</i>) were increased. This resulted in shifting predicted intestinal metabolic pathways involved in regulating adipocytes (i.e., mevalonate metabolism), energy harvest (i.e., pyruvate fermentation and glycolysis), appetite (i.e., chorismate biosynthesis) and metabolic disorders (i.e., isoprene biosynthesis, urea metabolism, and peptidoglycan biosynthesis). In conclusion, our study showed that CF extracts ameliorate intestinal metabolism in HF-induced obese mice by modulating the gut microbiota. |
| first_indexed | 2024-03-10T18:58:56Z |
| format | Article |
| id | doaj.art-0cbb2f6a61fa4e3e8cf6c7bacfa09028 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T18:58:56Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-0cbb2f6a61fa4e3e8cf6c7bacfa090282023-11-20T04:31:03ZengMDPI AGNutrients2072-66432020-06-01126184810.3390/nu12061848<i>Codium fragile</i> Ameliorates High-Fat Diet-Induced Metabolism by Modulating the Gut Microbiota in MiceJungman Kim0Jae Ho Choi1Taehwan Oh2Byungjae Ahn3Tatsuya Unno4Faculty of Biotechnology, School of Life Sciences, SARI, Jeju National University, Jeju 63243, KoreaSubtropical/Tropical Organism Gene Bank, Jeju National University, Jeju 63243, KoreaMarine Biotechnology Research Center, Jeonnam Bioindustry Foundation, Wando 59108, KoreaMarine Biotechnology Research Center, Jeonnam Bioindustry Foundation, Wando 59108, KoreaFaculty of Biotechnology, School of Life Sciences, SARI, Jeju National University, Jeju 63243, Korea<i>Codium fragile</i> (CF) is a functional seaweed food that has been used for its health effects, including immunostimulatory, anti-inflammatory, anti-obesity and anti-cancer activities, but the effect of CF extracts on obesity via regulation of intestinal microflora is still unknown. This study investigated anti-obesity effects of CF extracts on gut microbiota of diet-induced obese mice. C57BL/6 mice fed a high-fat (HF) diet were given CF extracts intragastrically for 12 weeks. CF extracts significantly decreased animal body weight and the size of adipocytes, while reducing serum levels of cholesterol and glucose. In addition, CF extracts significantly shifted the gut microbiota of mice by increasing the abundance of Bacteroidetes and decreasing the abundance of Verrucomicrobia species, in which the portion of beneficial bacteria (i.e., Ruminococcaceae, Lachnospiraceae and <i>Acetatifactor</i>) were increased. This resulted in shifting predicted intestinal metabolic pathways involved in regulating adipocytes (i.e., mevalonate metabolism), energy harvest (i.e., pyruvate fermentation and glycolysis), appetite (i.e., chorismate biosynthesis) and metabolic disorders (i.e., isoprene biosynthesis, urea metabolism, and peptidoglycan biosynthesis). In conclusion, our study showed that CF extracts ameliorate intestinal metabolism in HF-induced obese mice by modulating the gut microbiota.https://www.mdpi.com/2072-6643/12/6/1848<i>Codium fragile</i>gut microbiotahigh-fat dietintestinal metabolismobesity |
| spellingShingle | Jungman Kim Jae Ho Choi Taehwan Oh Byungjae Ahn Tatsuya Unno <i>Codium fragile</i> Ameliorates High-Fat Diet-Induced Metabolism by Modulating the Gut Microbiota in Mice Nutrients <i>Codium fragile</i> gut microbiota high-fat diet intestinal metabolism obesity |
| title | <i>Codium fragile</i> Ameliorates High-Fat Diet-Induced Metabolism by Modulating the Gut Microbiota in Mice |
| title_full | <i>Codium fragile</i> Ameliorates High-Fat Diet-Induced Metabolism by Modulating the Gut Microbiota in Mice |
| title_fullStr | <i>Codium fragile</i> Ameliorates High-Fat Diet-Induced Metabolism by Modulating the Gut Microbiota in Mice |
| title_full_unstemmed | <i>Codium fragile</i> Ameliorates High-Fat Diet-Induced Metabolism by Modulating the Gut Microbiota in Mice |
| title_short | <i>Codium fragile</i> Ameliorates High-Fat Diet-Induced Metabolism by Modulating the Gut Microbiota in Mice |
| title_sort | i codium fragile i ameliorates high fat diet induced metabolism by modulating the gut microbiota in mice |
| topic | <i>Codium fragile</i> gut microbiota high-fat diet intestinal metabolism obesity |
| url | https://www.mdpi.com/2072-6643/12/6/1848 |
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