RHD Positive Haplotype in D Negative Omani Blood Donor
The frequency of Rhesus D negative blood group in Omanis is 8.35% but the molecular background of this phenotype is unknown in the Omani population. The Rhesus D negative phenotype has a high molecular diversity. We report a rare case of serological D negative with existence of complete RHD gene in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2023-03-01
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| Series: | Oman Medical Journal |
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| Online Access: | https://omjournal.org/articleDetails.aspx?coType=1&aId=3370 |
| _version_ | 1797838955520983040 |
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| author | Mujtaba Al Lawati Badriya Al Balushi |
| author_facet | Mujtaba Al Lawati Badriya Al Balushi |
| author_sort | Mujtaba Al Lawati |
| collection | DOAJ |
| description | The frequency of Rhesus D negative blood group in Omanis is 8.35% but the molecular background of this phenotype is unknown in the Omani population. The Rhesus D negative phenotype has a high molecular diversity. We report a rare case of serological D negative with existence of complete RHD gene in a 43-year-old Omani male blood donor. Molecular analysis of RHD exons showed duplication across the boundary of intron 3 and exon 4. This is a 37 bp insert in RHD exon 4 along with c.609 G>A mutation. We are uncertain if the presence of RHDΨ is homozygous (RHDΨ/RHDΨ) or hemizygous (RHDΨ/del). Therefore, molecular basis of D zygosity determination would be a good approach to further explore the case. |
| first_indexed | 2024-04-09T15:50:24Z |
| format | Article |
| id | doaj.art-0cbb7764e1a54fdea87595b513266d89 |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-04-09T15:50:24Z |
| publishDate | 2023-03-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-0cbb7764e1a54fdea87595b513266d892023-04-26T07:22:27ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042023-03-01382e488e48810.5001/omj.2023.11RHD Positive Haplotype in D Negative Omani Blood DonorMujtaba Al Lawati0Badriya Al Balushi1Department of Medical Lab Sciences, Oman College of Health Sciences, Muscat, OmanCentral Blood Bank, Ministry of Health, Muscat, OmanThe frequency of Rhesus D negative blood group in Omanis is 8.35% but the molecular background of this phenotype is unknown in the Omani population. The Rhesus D negative phenotype has a high molecular diversity. We report a rare case of serological D negative with existence of complete RHD gene in a 43-year-old Omani male blood donor. Molecular analysis of RHD exons showed duplication across the boundary of intron 3 and exon 4. This is a 37 bp insert in RHD exon 4 along with c.609 G>A mutation. We are uncertain if the presence of RHDΨ is homozygous (RHDΨ/RHDΨ) or hemizygous (RHDΨ/del). Therefore, molecular basis of D zygosity determination would be a good approach to further explore the case.https://omjournal.org/articleDetails.aspx?coType=1&aId=3370antigenallelespseudogeneoman |
| spellingShingle | Mujtaba Al Lawati Badriya Al Balushi RHD Positive Haplotype in D Negative Omani Blood Donor Oman Medical Journal antigen alleles pseudogene oman |
| title | RHD Positive Haplotype in D Negative Omani Blood Donor |
| title_full | RHD Positive Haplotype in D Negative Omani Blood Donor |
| title_fullStr | RHD Positive Haplotype in D Negative Omani Blood Donor |
| title_full_unstemmed | RHD Positive Haplotype in D Negative Omani Blood Donor |
| title_short | RHD Positive Haplotype in D Negative Omani Blood Donor |
| title_sort | rhd positive haplotype in d negative omani blood donor |
| topic | antigen alleles pseudogene oman |
| url | https://omjournal.org/articleDetails.aspx?coType=1&aId=3370 |
| work_keys_str_mv | AT mujtabaallawati rhdpositivehaplotypeindnegativeomaniblooddonor AT badriyaalbalushi rhdpositivehaplotypeindnegativeomaniblooddonor |