miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities
MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological targets, has been the subject of countless studie...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/1/84 |
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| author | Wilson Huang Doru Paul George A. Calin Recep Bayraktar |
| author_facet | Wilson Huang Doru Paul George A. Calin Recep Bayraktar |
| author_sort | Wilson Huang |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological targets, has been the subject of countless studies over the years. Due to its preferential expression in hematopoietic cells, miR-142 has been found to be associated with numerous types of lymphomas and leukemias. This review elucidates the multifaceted role of miR-142 in human physiology, its influence on hematopoiesis and hematopoietic cells, and its intriguing involvement in exosome-mediated miR-142 transport. Moreover, we offer a comprehensive exploration of the genetic and molecular landscape of the miR-142 genomic locus, highlighting its mutations and dysregulation within hematological malignancies. Finally, we discuss potential avenues for harnessing the therapeutic potential of miR-142 in the context of hematological malignancies. |
| first_indexed | 2024-03-08T15:09:03Z |
| format | Article |
| id | doaj.art-0cbbb6c25b034ee58c450151a3b7617e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-08T15:09:03Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0cbbb6c25b034ee58c450151a3b7617e2024-01-10T14:53:29ZengMDPI AGCells2073-44092023-12-011318410.3390/cells13010084miR-142: A Master Regulator in Hematological Malignancies and Therapeutic OpportunitiesWilson Huang0Doru Paul1George A. Calin2Recep Bayraktar3Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADivision of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USADepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USACenter for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological targets, has been the subject of countless studies over the years. Due to its preferential expression in hematopoietic cells, miR-142 has been found to be associated with numerous types of lymphomas and leukemias. This review elucidates the multifaceted role of miR-142 in human physiology, its influence on hematopoiesis and hematopoietic cells, and its intriguing involvement in exosome-mediated miR-142 transport. Moreover, we offer a comprehensive exploration of the genetic and molecular landscape of the miR-142 genomic locus, highlighting its mutations and dysregulation within hematological malignancies. Finally, we discuss potential avenues for harnessing the therapeutic potential of miR-142 in the context of hematological malignancies.https://www.mdpi.com/2073-4409/13/1/84non-coding RNAmicroRNAmiR-142physiologyhematopoiesisexosome |
| spellingShingle | Wilson Huang Doru Paul George A. Calin Recep Bayraktar miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities Cells non-coding RNA microRNA miR-142 physiology hematopoiesis exosome |
| title | miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities |
| title_full | miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities |
| title_fullStr | miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities |
| title_full_unstemmed | miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities |
| title_short | miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities |
| title_sort | mir 142 a master regulator in hematological malignancies and therapeutic opportunities |
| topic | non-coding RNA microRNA miR-142 physiology hematopoiesis exosome |
| url | https://www.mdpi.com/2073-4409/13/1/84 |
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