Himalayan <i>Ficus palmata</i> L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors
Analgesic drugs like morphine and non-steroidal anti-inflammatory drugs exhibit several harmful effects. Here, we show for the first time the analgesic activity of <i>Ficus palmata</i> L. fruit extract (FPFE) on different analgesic rat models along with the in silico studies of some of t...
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MDPI AG
2021-08-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/10/8/1685 |
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| author | Devesh Tewari Pawan Gupta Sweta Bawari Archana N. Sah Davide Barreca Maryam Khayatkashani Hamid Reza Khayat Kashani |
| author_facet | Devesh Tewari Pawan Gupta Sweta Bawari Archana N. Sah Davide Barreca Maryam Khayatkashani Hamid Reza Khayat Kashani |
| author_sort | Devesh Tewari |
| collection | DOAJ |
| description | Analgesic drugs like morphine and non-steroidal anti-inflammatory drugs exhibit several harmful effects. Here, we show for the first time the analgesic activity of <i>Ficus palmata</i> L. fruit extract (FPFE) on different analgesic rat models along with the in silico studies of some of the main phytochemicals of this plant. We performed in vivo pain models, along with in silico docking studies against the active site of COX-2 protein and mu-opioid receptors. A significant (<i>p</i> < 0.05) analgesic effect of FPFE was observed, and it was found that rutin has good pose and score as compared to diclofenac and morphinan antagonist (X-ligand), and psoralen has binding affinity almost equal to diclofenac, but a lower binding affinity as compared to rutin. The results proved that <i>F. palmata</i> fruits have the potential to ameliorate painful conditions. |
| first_indexed | 2024-03-10T08:26:59Z |
| format | Article |
| id | doaj.art-0cbc0b12aa2a4bad9bfc02581feee654 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T08:26:59Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
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| series | Plants |
| spelling | doaj.art-0cbc0b12aa2a4bad9bfc02581feee6542023-11-22T09:20:08ZengMDPI AGPlants2223-77472021-08-01108168510.3390/plants10081685Himalayan <i>Ficus palmata</i> L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid ReceptorsDevesh Tewari0Pawan Gupta1Sweta Bawari2Archana N. Sah3Davide Barreca4Maryam Khayatkashani5Hamid Reza Khayat Kashani6Department of Pharmacognosy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, IndiaShree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Ganpat Vidyanagar, Mehsana 384012, IndiaDepartment of Pharmaceutical Sciences, Faculty of Technology, Bhimtal Campus, Kumaun University, Nainital 263136, IndiaDepartment of Pharmaceutical Sciences, Faculty of Technology, Bhimtal Campus, Kumaun University, Nainital 263136, IndiaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, ItalySchool of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran 14155-6559, IranDepartment of Neurosurgery, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1617763141, IranAnalgesic drugs like morphine and non-steroidal anti-inflammatory drugs exhibit several harmful effects. Here, we show for the first time the analgesic activity of <i>Ficus palmata</i> L. fruit extract (FPFE) on different analgesic rat models along with the in silico studies of some of the main phytochemicals of this plant. We performed in vivo pain models, along with in silico docking studies against the active site of COX-2 protein and mu-opioid receptors. A significant (<i>p</i> < 0.05) analgesic effect of FPFE was observed, and it was found that rutin has good pose and score as compared to diclofenac and morphinan antagonist (X-ligand), and psoralen has binding affinity almost equal to diclofenac, but a lower binding affinity as compared to rutin. The results proved that <i>F. palmata</i> fruits have the potential to ameliorate painful conditions.https://www.mdpi.com/2223-7747/10/8/1685<i>Ficus</i>painhot plateformalincyclooxygenaseneurogenic |
| spellingShingle | Devesh Tewari Pawan Gupta Sweta Bawari Archana N. Sah Davide Barreca Maryam Khayatkashani Hamid Reza Khayat Kashani Himalayan <i>Ficus palmata</i> L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors Plants <i>Ficus</i> pain hot plate formalin cyclooxygenase neurogenic |
| title | Himalayan <i>Ficus palmata</i> L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors |
| title_full | Himalayan <i>Ficus palmata</i> L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors |
| title_fullStr | Himalayan <i>Ficus palmata</i> L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors |
| title_full_unstemmed | Himalayan <i>Ficus palmata</i> L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors |
| title_short | Himalayan <i>Ficus palmata</i> L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors |
| title_sort | himalayan i ficus palmata i l fruit extract showed in vivo central and peripheral analgesic activity involving cox 2 and mu opioid receptors |
| topic | <i>Ficus</i> pain hot plate formalin cyclooxygenase neurogenic |
| url | https://www.mdpi.com/2223-7747/10/8/1685 |
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