Effects of brine- and NaCl- fermented carrots on lipid metabolism and gut microbiota in high-fat diet-fed mice
This study investigated the alterations in the phytochemical components and the antioxidant abilities of brine- and NaCl-fermented carrots and their effects on the lipid metabolism and microbial community in high-fat diet (HFD)-fed mice. Results showed that brine-fermentation significantly improved...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623001640 |
| _version_ | 1797819860286177280 |
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| author | Jichun Zhao Zhengwei Tan Ruyu Zhang Weizhou Li Fuhua Li Jian Ming |
| author_facet | Jichun Zhao Zhengwei Tan Ruyu Zhang Weizhou Li Fuhua Li Jian Ming |
| author_sort | Jichun Zhao |
| collection | DOAJ |
| description | This study investigated the alterations in the phytochemical components and the antioxidant abilities of brine- and NaCl-fermented carrots and their effects on the lipid metabolism and microbial community in high-fat diet (HFD)-fed mice. Results showed that brine-fermentation significantly improved the contents of total dietary fiber, total phenols and β-carotene by 57 %, 48 % and 117 %, respectively. Fermented carrots possessed a higher level of antioxidant activities (P < 0.05). Furthermore, fermented carrot attenuated the increase in body weight, alleviated liver injury and oxidative stress but also promoted the lipid metabolism and reduced fatty acid accumulation in vivo, which were correlated with the total phenols and dietary fiber contents. Further investigation demonstrated that fermented carrots can attenuate HFD-induced lipid accumulation through the AMPK pathway and restoring the gut microbiota in HFD mice. Overall, fermented carrots can modulate the lipid accumulation in the HFD mice through the AMPK pathway and the microbiota community. |
| first_indexed | 2024-03-13T09:28:51Z |
| format | Article |
| id | doaj.art-0cbc181b18b7432aae52549d47287869 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-13T09:28:51Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-0cbc181b18b7432aae52549d472878692023-05-26T04:21:12ZengElsevierJournal of Functional Foods1756-46462023-06-01105105564Effects of brine- and NaCl- fermented carrots on lipid metabolism and gut microbiota in high-fat diet-fed miceJichun Zhao0Zhengwei Tan1Ruyu Zhang2Weizhou Li3Fuhua Li4Jian Ming5College of Food Science, Southwest University, Chongqing 400715, People’s Republic of ChinaCollege of Food Science, Southwest University, Chongqing 400715, People’s Republic of ChinaCollege of Food Science, Southwest University, Chongqing 400715, People’s Republic of ChinaCollege of Food Science, Southwest University, Chongqing 400715, People’s Republic of ChinaCollege of Food Science, Southwest University, Chongqing 400715, People’s Republic of ChinaCorresponding author at: College of Food Science, Southwest University, Tiansheng Road 2, Chongqing, People’s Republic of China.; College of Food Science, Southwest University, Chongqing 400715, People’s Republic of ChinaThis study investigated the alterations in the phytochemical components and the antioxidant abilities of brine- and NaCl-fermented carrots and their effects on the lipid metabolism and microbial community in high-fat diet (HFD)-fed mice. Results showed that brine-fermentation significantly improved the contents of total dietary fiber, total phenols and β-carotene by 57 %, 48 % and 117 %, respectively. Fermented carrots possessed a higher level of antioxidant activities (P < 0.05). Furthermore, fermented carrot attenuated the increase in body weight, alleviated liver injury and oxidative stress but also promoted the lipid metabolism and reduced fatty acid accumulation in vivo, which were correlated with the total phenols and dietary fiber contents. Further investigation demonstrated that fermented carrots can attenuate HFD-induced lipid accumulation through the AMPK pathway and restoring the gut microbiota in HFD mice. Overall, fermented carrots can modulate the lipid accumulation in the HFD mice through the AMPK pathway and the microbiota community.http://www.sciencedirect.com/science/article/pii/S1756464623001640Fermented carrotsHigh-fat dietFat metabolismGut microbiota |
| spellingShingle | Jichun Zhao Zhengwei Tan Ruyu Zhang Weizhou Li Fuhua Li Jian Ming Effects of brine- and NaCl- fermented carrots on lipid metabolism and gut microbiota in high-fat diet-fed mice Journal of Functional Foods Fermented carrots High-fat diet Fat metabolism Gut microbiota |
| title | Effects of brine- and NaCl- fermented carrots on lipid metabolism and gut microbiota in high-fat diet-fed mice |
| title_full | Effects of brine- and NaCl- fermented carrots on lipid metabolism and gut microbiota in high-fat diet-fed mice |
| title_fullStr | Effects of brine- and NaCl- fermented carrots on lipid metabolism and gut microbiota in high-fat diet-fed mice |
| title_full_unstemmed | Effects of brine- and NaCl- fermented carrots on lipid metabolism and gut microbiota in high-fat diet-fed mice |
| title_short | Effects of brine- and NaCl- fermented carrots on lipid metabolism and gut microbiota in high-fat diet-fed mice |
| title_sort | effects of brine and nacl fermented carrots on lipid metabolism and gut microbiota in high fat diet fed mice |
| topic | Fermented carrots High-fat diet Fat metabolism Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623001640 |
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