Systematic review and meta-analysis: a critical examination of the methodology
Nowadays, the pyramid of evidence is the main model of decision-making for healthcare professionals. According to this concept, data from randomized clinical trials (RCTs) are considered lower in hierarchy than data obtained from systematic reviews (SRs) and meta-analyses (MAs). However, it заменить...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2023-10-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/2923 |
| _version_ | 1797231996927213568 |
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| author | S. Yu. Martsevich S.Yu. A. R. Navasardyan K. V. Lobastov M. V. Mikaelyan E. V. Mikhaylenko A. Yu. Suvorov I. V. Schastlivtsev O. N. Dzhioeva V. V. Matveev E. S. Akimova V. V. Sytkov E. Dubar O. M. Drapkina |
| author_facet | S. Yu. Martsevich S.Yu. A. R. Navasardyan K. V. Lobastov M. V. Mikaelyan E. V. Mikhaylenko A. Yu. Suvorov I. V. Schastlivtsev O. N. Dzhioeva V. V. Matveev E. S. Akimova V. V. Sytkov E. Dubar O. M. Drapkina |
| author_sort | S. Yu. Martsevich S.Yu. |
| collection | DOAJ |
| description | Nowadays, the pyramid of evidence is the main model of decision-making for healthcare professionals. According to this concept, data from randomized clinical trials (RCTs) are considered lower in hierarchy than data obtained from systematic reviews (SRs) and meta-analyses (MAs). However, it заменить на:is not established whether it is appropriate to rate large RCTs with hard endpoints lower than SRs and MAs that combine data from smaller RCTs of questionable quality, or even from prospective or retrospective observational studies. It is also important to consider that in addition to assessing the quality of the studies included in the SRs and MAs, it is necessary to assess the accuracy of the SRs and MAs themselves. If not rigorously conducted, they can also contain systematic errors, leading to increased risks of data manipulation. The publication covers the main stages and principles of preparing SRs and MAs, common types of systematic errors that can arise at each stage, and methods to minimize them. We believe that the tools, knowledge, and skills we offer will help practicing doctors and healthcare professionals critically assess the results obtained from SRs and MAs in terms of methodology and the mitigation of potential data manipulation risks. |
| first_indexed | 2024-03-08T13:59:44Z |
| format | Article |
| id | doaj.art-0cbcda50d7d54cd38b6ce975ce7ef017 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T15:53:16Z |
| publishDate | 2023-10-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-0cbcda50d7d54cd38b6ce975ce7ef0172024-04-01T07:43:43ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532023-10-0119438239710.20996/1819-6446-2023-29232141Systematic review and meta-analysis: a critical examination of the methodologyS. Yu. Martsevich S.Yu.0A. R. Navasardyan1K. V. Lobastov2M. V. Mikaelyan3E. V. Mikhaylenko4A. Yu. Suvorov5I. V. Schastlivtsev6O. N. Dzhioeva7V. V. Matveev8E. S. Akimova9V. V. Sytkov10E. Dubar11O. M. Drapkina12National Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive Medicine; AO BayerPirogov Russian National Research Medical UniversityAO BayerI. M. Sechenov First Moscow State Medical UniversityI. M. Sechenov First Moscow State Medical UniversityPirogov Russian National Research Medical UniversityNational Medical Research Center for Therapy and Preventive MedicineM. F.Vladimirsky Moscow Regional Research and Clinical Institute; Siemens healthineers LLCA. I. Evdokimov Moscow State University of Medicine and DentistryA. I.Evdokimov Moscow State University of Medicine and DentistryS. S.Yudin City Clinical HospitaNational Medical Research Center for Therapy and Preventive MedicineNowadays, the pyramid of evidence is the main model of decision-making for healthcare professionals. According to this concept, data from randomized clinical trials (RCTs) are considered lower in hierarchy than data obtained from systematic reviews (SRs) and meta-analyses (MAs). However, it заменить на:is not established whether it is appropriate to rate large RCTs with hard endpoints lower than SRs and MAs that combine data from smaller RCTs of questionable quality, or even from prospective or retrospective observational studies. It is also important to consider that in addition to assessing the quality of the studies included in the SRs and MAs, it is necessary to assess the accuracy of the SRs and MAs themselves. If not rigorously conducted, they can also contain systematic errors, leading to increased risks of data manipulation. The publication covers the main stages and principles of preparing SRs and MAs, common types of systematic errors that can arise at each stage, and methods to minimize them. We believe that the tools, knowledge, and skills we offer will help practicing doctors and healthcare professionals critically assess the results obtained from SRs and MAs in terms of methodology and the mitigation of potential data manipulation risks.https://www.rpcardio.online/jour/article/view/2923systematic reviewmeta-analysisrandomized controlled trialspyramid of evidenceevidence-based medicinenarrative reviewbiaspublication bias |
| spellingShingle | S. Yu. Martsevich S.Yu. A. R. Navasardyan K. V. Lobastov M. V. Mikaelyan E. V. Mikhaylenko A. Yu. Suvorov I. V. Schastlivtsev O. N. Dzhioeva V. V. Matveev E. S. Akimova V. V. Sytkov E. Dubar O. M. Drapkina Systematic review and meta-analysis: a critical examination of the methodology Рациональная фармакотерапия в кардиологии systematic review meta-analysis randomized controlled trials pyramid of evidence evidence-based medicine narrative review bias publication bias |
| title | Systematic review and meta-analysis: a critical examination of the methodology |
| title_full | Systematic review and meta-analysis: a critical examination of the methodology |
| title_fullStr | Systematic review and meta-analysis: a critical examination of the methodology |
| title_full_unstemmed | Systematic review and meta-analysis: a critical examination of the methodology |
| title_short | Systematic review and meta-analysis: a critical examination of the methodology |
| title_sort | systematic review and meta analysis a critical examination of the methodology |
| topic | systematic review meta-analysis randomized controlled trials pyramid of evidence evidence-based medicine narrative review bias publication bias |
| url | https://www.rpcardio.online/jour/article/view/2923 |
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