Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in rats
Physiological responses to nociceptive stimuli are initiated within tens of milliseconds, but the corresponding sub-second behavioral responses have not been adequately explored in awake, unrestrained animals. A detailed understanding of these responses is crucial for progress in pain neurobiology....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-05-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/23584 |
| _version_ | 1811180650805329920 |
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| author | Dvir Blivis Gal Haspel Philip Z Mannes Michael J O'Donovan Michael J Iadarola |
| author_facet | Dvir Blivis Gal Haspel Philip Z Mannes Michael J O'Donovan Michael J Iadarola |
| author_sort | Dvir Blivis |
| collection | DOAJ |
| description | Physiological responses to nociceptive stimuli are initiated within tens of milliseconds, but the corresponding sub-second behavioral responses have not been adequately explored in awake, unrestrained animals. A detailed understanding of these responses is crucial for progress in pain neurobiology. Here, high-speed videography during nociceptive Aδ fiber stimulation demonstrated engagement of a multi-segmental motor program coincident with, or even preceding, withdrawal of the stimulated paw. The motor program included early head orientation and adjustments of the torso and un-stimulated paws. Moreover, we observed a remarkably potent gating mechanism when the animal was standing on its hindlimbs and which was partially dependent on the endogenous opioid system. These data reveal a profound, immediate and precise integration of nociceptive inputs with ongoing motor activities leading to the initiation of complex, yet behaviorally appropriate, response patterns and the mobilization of a new type of analgesic mechanism within this early temporal nociceptive window. |
| first_indexed | 2024-04-11T09:06:46Z |
| format | Article |
| id | doaj.art-0cbd03e19f5845b095e7c9283316b83f |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:06:46Z |
| publishDate | 2017-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-0cbd03e19f5845b095e7c9283316b83f2022-12-22T04:32:36ZengeLife Sciences Publications LtdeLife2050-084X2017-05-01610.7554/eLife.23584Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in ratsDvir Blivis0https://orcid.org/0000-0001-6203-7325Gal Haspel1https://orcid.org/0000-0001-6701-697XPhilip Z Mannes2Michael J O'Donovan3https://orcid.org/0000-0003-2487-7547Michael J Iadarola4https://orcid.org/0000-0001-7188-9810Developmental Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United StatesDevelopmental Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States; Federated Department of Biological Sciences, New Jersey Institute of Technology, and Rutgers, Newark, United StatesMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Disorders, National Institutes of Health, Bethesda, United StatesDevelopmental Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United StatesDepartment of Perioperative Medicine, Clinical Center, National Institutes of Health, Bethesda, United StatesPhysiological responses to nociceptive stimuli are initiated within tens of milliseconds, but the corresponding sub-second behavioral responses have not been adequately explored in awake, unrestrained animals. A detailed understanding of these responses is crucial for progress in pain neurobiology. Here, high-speed videography during nociceptive Aδ fiber stimulation demonstrated engagement of a multi-segmental motor program coincident with, or even preceding, withdrawal of the stimulated paw. The motor program included early head orientation and adjustments of the torso and un-stimulated paws. Moreover, we observed a remarkably potent gating mechanism when the animal was standing on its hindlimbs and which was partially dependent on the endogenous opioid system. These data reveal a profound, immediate and precise integration of nociceptive inputs with ongoing motor activities leading to the initiation of complex, yet behaviorally appropriate, response patterns and the mobilization of a new type of analgesic mechanism within this early temporal nociceptive window.https://elifesciences.org/articles/23584nociceptionsensory-motor integrationopioidspainhigh speed videographyA-delta fibers |
| spellingShingle | Dvir Blivis Gal Haspel Philip Z Mannes Michael J O'Donovan Michael J Iadarola Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in rats eLife nociception sensory-motor integration opioids pain high speed videography A-delta fibers |
| title | Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in rats |
| title_full | Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in rats |
| title_fullStr | Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in rats |
| title_full_unstemmed | Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in rats |
| title_short | Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in rats |
| title_sort | identification of a novel spinal nociceptive motor gate control for aδ pain stimuli in rats |
| topic | nociception sensory-motor integration opioids pain high speed videography A-delta fibers |
| url | https://elifesciences.org/articles/23584 |
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