Functionalized hydrogels in neural injury repairing
Repairing injuries to the nervous system has always been a prominent topic in clinical research. Direct suturing and nerve displacement surgery are the primary treatment options, but they may not be suitable for long nerve injuries and may require sacrificing the functionality of other autologous ne...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1199299/full |
| _version_ | 1797800681622470656 |
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| author | Wenqian Zhao Hui Tu Jianxiao Chen Jing Wang Haoting Liu Fengshou Zhang Jing Li |
| author_facet | Wenqian Zhao Hui Tu Jianxiao Chen Jing Wang Haoting Liu Fengshou Zhang Jing Li |
| author_sort | Wenqian Zhao |
| collection | DOAJ |
| description | Repairing injuries to the nervous system has always been a prominent topic in clinical research. Direct suturing and nerve displacement surgery are the primary treatment options, but they may not be suitable for long nerve injuries and may require sacrificing the functionality of other autologous nerves. With the emergence of tissue engineering, hydrogel materials have been identified as a promising technology with clinical translation potential for repairing nervous system injuries due to their excellent biocompatibility and ability to release or deliver functional ions. By controlling their composition and structure, hydrogels can be Functionalized and almost fully matched with nerve tissue and even simulate nerve conduction function and mechanical properties. Thus, they are suitable for repairing injuries to both the central and peripheral nervous systems. This article provides a review of recent research progress in functionalized hydrogels for nerve injury repair, highlighting the design differences among various materials and future research directions. We strongly believe that the development of functionalized hydrogels has great potential for improving the clinical treatment of nerve injuries. |
| first_indexed | 2024-03-13T04:38:58Z |
| format | Article |
| id | doaj.art-0cbe22a7f19e4be4ba3fe7626dbe3d40 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T04:38:58Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-0cbe22a7f19e4be4ba3fe7626dbe3d402023-06-19T06:29:26ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-06-011710.3389/fnins.2023.11992991199299Functionalized hydrogels in neural injury repairingWenqian Zhao0Hui Tu1Jianxiao Chen2Jing Wang3Haoting Liu4Fengshou Zhang5Jing Li6College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, ChinaDepartment of Nephrology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, ChinaOffice of Science and Technology, Henan University of Science and Technology, Luoyang, ChinaRepairing injuries to the nervous system has always been a prominent topic in clinical research. Direct suturing and nerve displacement surgery are the primary treatment options, but they may not be suitable for long nerve injuries and may require sacrificing the functionality of other autologous nerves. With the emergence of tissue engineering, hydrogel materials have been identified as a promising technology with clinical translation potential for repairing nervous system injuries due to their excellent biocompatibility and ability to release or deliver functional ions. By controlling their composition and structure, hydrogels can be Functionalized and almost fully matched with nerve tissue and even simulate nerve conduction function and mechanical properties. Thus, they are suitable for repairing injuries to both the central and peripheral nervous systems. This article provides a review of recent research progress in functionalized hydrogels for nerve injury repair, highlighting the design differences among various materials and future research directions. We strongly believe that the development of functionalized hydrogels has great potential for improving the clinical treatment of nerve injuries.https://www.frontiersin.org/articles/10.3389/fnins.2023.1199299/fullfunctionalized hydrogelnerve injurytissue engineeringnerve regenerationnanomaterial |
| spellingShingle | Wenqian Zhao Hui Tu Jianxiao Chen Jing Wang Haoting Liu Fengshou Zhang Jing Li Functionalized hydrogels in neural injury repairing Frontiers in Neuroscience functionalized hydrogel nerve injury tissue engineering nerve regeneration nanomaterial |
| title | Functionalized hydrogels in neural injury repairing |
| title_full | Functionalized hydrogels in neural injury repairing |
| title_fullStr | Functionalized hydrogels in neural injury repairing |
| title_full_unstemmed | Functionalized hydrogels in neural injury repairing |
| title_short | Functionalized hydrogels in neural injury repairing |
| title_sort | functionalized hydrogels in neural injury repairing |
| topic | functionalized hydrogel nerve injury tissue engineering nerve regeneration nanomaterial |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1199299/full |
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