Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer
The total synthesis of (3R,5R)-harzialactone A (1) and its (3R,5S)-isomer (2) is described. Epoxide opening with thioacetal and diastereoselective reductions are used as key reactions.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2010-01-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.6.8 |
| _version_ | 1818918829763330048 |
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| author | Gowravaram Sabitha Rangavajjula Srinivas Sukant K. Das Jhillu S. Yadav |
| author_facet | Gowravaram Sabitha Rangavajjula Srinivas Sukant K. Das Jhillu S. Yadav |
| author_sort | Gowravaram Sabitha |
| collection | DOAJ |
| description | The total synthesis of (3R,5R)-harzialactone A (1) and its (3R,5S)-isomer (2) is described. Epoxide opening with thioacetal and diastereoselective reductions are used as key reactions. |
| first_indexed | 2024-12-20T00:56:11Z |
| format | Article |
| id | doaj.art-0cbf944477374a3c9df4cd25bf81ba00 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-20T00:56:11Z |
| publishDate | 2010-01-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-0cbf944477374a3c9df4cd25bf81ba002022-12-21T19:59:06ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972010-01-0161810.3762/bjoc.6.81860-5397-6-8Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomerGowravaram Sabitha0Rangavajjula Srinivas1Sukant K. Das2Jhillu S. Yadav3Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: +91-40-27160512Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: +91-40-27160512Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: +91-40-27160512Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: +91-40-27160512The total synthesis of (3R,5R)-harzialactone A (1) and its (3R,5S)-isomer (2) is described. Epoxide opening with thioacetal and diastereoselective reductions are used as key reactions.https://doi.org/10.3762/bjoc.6.8dithianeharzialactone Ahydroxyl directed reductionstereoisomer |
| spellingShingle | Gowravaram Sabitha Rangavajjula Srinivas Sukant K. Das Jhillu S. Yadav Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer Beilstein Journal of Organic Chemistry dithiane harzialactone A hydroxyl directed reduction stereoisomer |
| title | Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer |
| title_full | Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer |
| title_fullStr | Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer |
| title_full_unstemmed | Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer |
| title_short | Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer |
| title_sort | synthesis of 3r 5r harzialactone a and its 3r 5s isomer |
| topic | dithiane harzialactone A hydroxyl directed reduction stereoisomer |
| url | https://doi.org/10.3762/bjoc.6.8 |
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