Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose Monitoring
The influence of the as-grown zinc oxide nanorods (ZnO NRs) on the fabricated electrochemical sensor for in vitro glucose monitoring were investigated. A direct growth of ZnO NRs was performed on the Si/SiO2/Au electrode, using hydrothermal and sol-gel techniques at low temperatures. The structure,...
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MDPI AG
2017-01-01
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| Series: | Chemosensors |
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| Online Access: | http://www.mdpi.com/2227-9040/5/1/4 |
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| author | Mohammed Marie Omar Manasreh |
| author_facet | Mohammed Marie Omar Manasreh |
| author_sort | Mohammed Marie |
| collection | DOAJ |
| description | The influence of the as-grown zinc oxide nanorods (ZnO NRs) on the fabricated electrochemical sensor for in vitro glucose monitoring were investigated. A direct growth of ZnO NRs was performed on the Si/SiO2/Au electrode, using hydrothermal and sol-gel techniques at low temperatures. The structure, consisting of a Si/SiO2/Au/GOx/Nafion membrane, was considered as a baseline, and it was tested under several applied potential 0.1–0.8 V. The immobilized working electrode, with GOx and a nafion membrane, was characterized amperometrically using a source meter Keithely 2410, and an electrochemical impedance Gamry potentiostat. The sensor exhibited the following: a high sensitivity of ~0.468 mA/cm2 mM, a low detection limit in the order of 166.6 µM, and a fast and sharp response time of around 2 s. The highest sensitivity and the lowest limit of detection were obtained at 0.4 volt, after the growth of ZnO NRs. The highest net sensitivity was obtained after subtracting the sensitivity of the baseline, and it was in the order of 0.315 mA/cm2·mM. The device was tested with a range of glucose concentrations from 1–10 mM, showing a linear line from 3–8 mM, and the device was saturated after exceeding high concentrations of glucose. Such devices can be used for in vitro glucose monitoring, since glucose changes can be accurately detected. |
| first_indexed | 2024-04-12T08:28:19Z |
| format | Article |
| id | doaj.art-0cc0ff6fb51e45f1b2ad24ddeabc6509 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-04-12T08:28:19Z |
| publishDate | 2017-01-01 |
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| series | Chemosensors |
| spelling | doaj.art-0cc0ff6fb51e45f1b2ad24ddeabc65092022-12-22T03:40:18ZengMDPI AGChemosensors2227-90402017-01-0151410.3390/chemosensors5010004chemosensors5010004Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose MonitoringMohammed Marie0Omar Manasreh1Microelectronics and Photonics graduate program, University of Arkansas, Fayetteville, AR 72701, USADepartment of Electrical Engineering, University of Arkansas, Fayetteville, AR 72701, USAThe influence of the as-grown zinc oxide nanorods (ZnO NRs) on the fabricated electrochemical sensor for in vitro glucose monitoring were investigated. A direct growth of ZnO NRs was performed on the Si/SiO2/Au electrode, using hydrothermal and sol-gel techniques at low temperatures. The structure, consisting of a Si/SiO2/Au/GOx/Nafion membrane, was considered as a baseline, and it was tested under several applied potential 0.1–0.8 V. The immobilized working electrode, with GOx and a nafion membrane, was characterized amperometrically using a source meter Keithely 2410, and an electrochemical impedance Gamry potentiostat. The sensor exhibited the following: a high sensitivity of ~0.468 mA/cm2 mM, a low detection limit in the order of 166.6 µM, and a fast and sharp response time of around 2 s. The highest sensitivity and the lowest limit of detection were obtained at 0.4 volt, after the growth of ZnO NRs. The highest net sensitivity was obtained after subtracting the sensitivity of the baseline, and it was in the order of 0.315 mA/cm2·mM. The device was tested with a range of glucose concentrations from 1–10 mM, showing a linear line from 3–8 mM, and the device was saturated after exceeding high concentrations of glucose. Such devices can be used for in vitro glucose monitoring, since glucose changes can be accurately detected.http://www.mdpi.com/2227-9040/5/1/4electrochemical sensorglucose oxidaseamperometricsensitivityconcentrations. |
| spellingShingle | Mohammed Marie Omar Manasreh Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose Monitoring Chemosensors electrochemical sensor glucose oxidase amperometric sensitivity concentrations. |
| title | Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose Monitoring |
| title_full | Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose Monitoring |
| title_fullStr | Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose Monitoring |
| title_full_unstemmed | Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose Monitoring |
| title_short | Investigation of the Influence of the As-Grown ZnO Nanorods and Applied Potentials on an Electrochemical Sensor for In-Vitro Glucose Monitoring |
| title_sort | investigation of the influence of the as grown zno nanorods and applied potentials on an electrochemical sensor for in vitro glucose monitoring |
| topic | electrochemical sensor glucose oxidase amperometric sensitivity concentrations. |
| url | http://www.mdpi.com/2227-9040/5/1/4 |
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