Drug-induced phospholipidosis is not correlated with the inhibition of SARS-CoV-2 - inhibition of SARS-CoV-2 is cell line-specific

Drug-induced phospholipidosis is not correlated with the inhibition of SARS-CoV-2 - inhibition of SARS-CoV-2 is cell line-specific

Recently, Tummino et al. reported that 34 compounds, including Chloroquine and Fluoxetine, inhibit SARS-CoV-2 replication by inducing phospholipidosis, although Chloroquine failed to suppress viral replication in Calu-3 cells and patients. In contrast, Fluoxetine represses viral replication in human...

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Bibliographic Details
Main Authors: Viktoria Diesendorf, Valeria Roll, Nina Geiger, Sofie Fähr, Helena Obernolte, Katherina Sewald, Jochen Bodem
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
SARS-CoV-2
phospholipidosis
Vero E6
PCLS
Calu-3
antivirals
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1100028/full

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