The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study
Wenbin Lu,* Shengwei Lin,* Cheng Wang, Peipei Jin, Jinjun Bian Faculty of Anesthesiology, Changhai Hospital, Naval Medical University/Second Military Medical University, PLA, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespond...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-11-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/the-potential-value-of-systemic-inflammation-response-index-on-deliriu-peer-reviewed-fulltext-article-IJGM |
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| author | Lu W Lin S Wang C Jin P Bian J |
| author_facet | Lu W Lin S Wang C Jin P Bian J |
| author_sort | Lu W |
| collection | DOAJ |
| description | Wenbin Lu,* Shengwei Lin,* Cheng Wang, Peipei Jin, Jinjun Bian Faculty of Anesthesiology, Changhai Hospital, Naval Medical University/Second Military Medical University, PLA, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Peipei Jin; Jinjun Bian, Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, 168, Changhai Road, Shanghai, 200433, People’s Republic of China, Tel/Fax +86-021-31161886 ; +86-021-31161841, Email kingpei89@163.com; jinjunbicu@163.comPurpose: To explore the relationship between the systemic inflammation response index (SIRI) and postoperative delirium (POD) in older patients with hip arthroplasty surgery.Patients and Methods: Older patients who underwent elective hip arthroplasty surgery were included in this retrospective study. SIRI, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were collected from blood routine examination at admission. Binary logistic regression analysis was performed to evaluate the association between SIRI levels and POD was analyzed.Results: Ultimately, 116 older patients who met the inclusion criteria were assessed. Thirty-four (29%) of 116 patients diagnosed with POD were defined as the POD group, and the rest consisted of the Non-POD group. Compared with non-POD patients, POD patients showed significantly higher levels of SIRI (P < 0.001) and NLR (P = 0.002) at admission. There was no significance in the levels of PLR between two groups. SIRI was independently associated with the occurrence of POD in multivariate logistic regression analysis [odds ratio (OR) = 3.34, 95% confidence interval (95% CI) = 1.26– 8.85, P = 0.016]. Receiver operating characteristic curve analysis indicated that SIRI with an optimal cutoff value of 0.987 predicted the POD with a sensitivity of 88.2% and specificity of 74.4%, and the area under the curve was 0.82 (95% CI, 0.74– 0.90, P < 0.01).Conclusion: Preoperative SIRI and NLR levels in the blood are associated with the occurrence of POD. Moreover, preoperative SIRI level is a useful candidate biomarker to identify delirium after elective hip arthroplasty surgery in older patients.Keywords: geriatric, hip arthroplasty, neutrophil to lymphocyte ratio, postoperative delirium, platelet to lymphocyte ratio, systemic inflammation response index |
| first_indexed | 2024-03-10T11:59:32Z |
| format | Article |
| id | doaj.art-0cc41733d8884bef9346c1ffb5384d49 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-03-10T11:59:32Z |
| publishDate | 2023-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-0cc41733d8884bef9346c1ffb5384d492023-11-21T17:01:05ZengDove Medical PressInternational Journal of General Medicine1178-70742023-11-01Volume 165355536288345The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective StudyLu WLin SWang CJin PBian JWenbin Lu,* Shengwei Lin,* Cheng Wang, Peipei Jin, Jinjun Bian Faculty of Anesthesiology, Changhai Hospital, Naval Medical University/Second Military Medical University, PLA, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Peipei Jin; Jinjun Bian, Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, 168, Changhai Road, Shanghai, 200433, People’s Republic of China, Tel/Fax +86-021-31161886 ; +86-021-31161841, Email kingpei89@163.com; jinjunbicu@163.comPurpose: To explore the relationship between the systemic inflammation response index (SIRI) and postoperative delirium (POD) in older patients with hip arthroplasty surgery.Patients and Methods: Older patients who underwent elective hip arthroplasty surgery were included in this retrospective study. SIRI, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were collected from blood routine examination at admission. Binary logistic regression analysis was performed to evaluate the association between SIRI levels and POD was analyzed.Results: Ultimately, 116 older patients who met the inclusion criteria were assessed. Thirty-four (29%) of 116 patients diagnosed with POD were defined as the POD group, and the rest consisted of the Non-POD group. Compared with non-POD patients, POD patients showed significantly higher levels of SIRI (P < 0.001) and NLR (P = 0.002) at admission. There was no significance in the levels of PLR between two groups. SIRI was independently associated with the occurrence of POD in multivariate logistic regression analysis [odds ratio (OR) = 3.34, 95% confidence interval (95% CI) = 1.26– 8.85, P = 0.016]. Receiver operating characteristic curve analysis indicated that SIRI with an optimal cutoff value of 0.987 predicted the POD with a sensitivity of 88.2% and specificity of 74.4%, and the area under the curve was 0.82 (95% CI, 0.74– 0.90, P < 0.01).Conclusion: Preoperative SIRI and NLR levels in the blood are associated with the occurrence of POD. Moreover, preoperative SIRI level is a useful candidate biomarker to identify delirium after elective hip arthroplasty surgery in older patients.Keywords: geriatric, hip arthroplasty, neutrophil to lymphocyte ratio, postoperative delirium, platelet to lymphocyte ratio, systemic inflammation response indexhttps://www.dovepress.com/the-potential-value-of-systemic-inflammation-response-index-on-deliriu-peer-reviewed-fulltext-article-IJGMgeriatrichip arthroplastyneutrophil to lymphocyte ratiopostoperative deliriumplatelet to lymphocyte ratiosystemic inflammation response index |
| spellingShingle | Lu W Lin S Wang C Jin P Bian J The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study International Journal of General Medicine geriatric hip arthroplasty neutrophil to lymphocyte ratio postoperative delirium platelet to lymphocyte ratio systemic inflammation response index |
| title | The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study |
| title_full | The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study |
| title_fullStr | The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study |
| title_full_unstemmed | The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study |
| title_short | The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study |
| title_sort | potential value of systemic inflammation response index on delirium after hip arthroplasty surgery in older patients a retrospective study |
| topic | geriatric hip arthroplasty neutrophil to lymphocyte ratio postoperative delirium platelet to lymphocyte ratio systemic inflammation response index |
| url | https://www.dovepress.com/the-potential-value-of-systemic-inflammation-response-index-on-deliriu-peer-reviewed-fulltext-article-IJGM |
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