Intestinal homeostasis in autoimmune liver diseases
Abstract. Intestinal homeostasis depends on complex interactions between the gut microbiota and host immune system. Emerging evidence indicates that the intestinal microbiota is a key player in autoimmune liver disease (AILD). Autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cho...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2022-07-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002291 |
| _version_ | 1798001247894110208 |
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| author | Qiaoyan Liu Wei He Ruqi Tang Xiong Ma Yuanyuan Ji |
| author_facet | Qiaoyan Liu Wei He Ruqi Tang Xiong Ma Yuanyuan Ji |
| author_sort | Qiaoyan Liu |
| collection | DOAJ |
| description | Abstract. Intestinal homeostasis depends on complex interactions between the gut microbiota and host immune system. Emerging evidence indicates that the intestinal microbiota is a key player in autoimmune liver disease (AILD). Autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and IgG4-related sclerosing cholangitis have been linked to gut dysbiosis. Diverse mechanisms contribute to disturbances in intestinal homeostasis in AILD. Bacterial translocation and molecular mimicry can lead to hepatic inflammation and immune activation. Additionally, the gut and liver are continuously exposed to microbial metabolic products, mediating variable effects on liver immune pathologies. Importantly, microbiota-specific or associated immune responses, either hepatic or systemic, are abnormal in AILD. Comprehensive knowledge about host-microbiota interactions, included but not limited to this review, facilitates novel clinical practice from a microbiome-based perspective. However, many challenges and controversies remain in the microbiota field of AILD, and there is an urgent need for future investigations. |
| first_indexed | 2024-04-11T11:33:11Z |
| format | Article |
| id | doaj.art-0cc4799bb3874e6ba1a91e9168ebbaec |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-04-11T11:33:11Z |
| publishDate | 2022-07-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-0cc4799bb3874e6ba1a91e9168ebbaec2022-12-22T04:26:03ZengWolters KluwerChinese Medical Journal0366-69992542-56412022-07-01135141642165210.1097/CM9.0000000000002291202207200-00002Intestinal homeostasis in autoimmune liver diseasesQiaoyan Liu0Wei He1Ruqi Tang2Xiong Ma3Yuanyuan Ji4Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China.Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China.Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China.Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China.Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai 200001, China.Abstract. Intestinal homeostasis depends on complex interactions between the gut microbiota and host immune system. Emerging evidence indicates that the intestinal microbiota is a key player in autoimmune liver disease (AILD). Autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and IgG4-related sclerosing cholangitis have been linked to gut dysbiosis. Diverse mechanisms contribute to disturbances in intestinal homeostasis in AILD. Bacterial translocation and molecular mimicry can lead to hepatic inflammation and immune activation. Additionally, the gut and liver are continuously exposed to microbial metabolic products, mediating variable effects on liver immune pathologies. Importantly, microbiota-specific or associated immune responses, either hepatic or systemic, are abnormal in AILD. Comprehensive knowledge about host-microbiota interactions, included but not limited to this review, facilitates novel clinical practice from a microbiome-based perspective. However, many challenges and controversies remain in the microbiota field of AILD, and there is an urgent need for future investigations.http://journals.lww.com/10.1097/CM9.0000000000002291 |
| spellingShingle | Qiaoyan Liu Wei He Ruqi Tang Xiong Ma Yuanyuan Ji Intestinal homeostasis in autoimmune liver diseases Chinese Medical Journal |
| title | Intestinal homeostasis in autoimmune liver diseases |
| title_full | Intestinal homeostasis in autoimmune liver diseases |
| title_fullStr | Intestinal homeostasis in autoimmune liver diseases |
| title_full_unstemmed | Intestinal homeostasis in autoimmune liver diseases |
| title_short | Intestinal homeostasis in autoimmune liver diseases |
| title_sort | intestinal homeostasis in autoimmune liver diseases |
| url | http://journals.lww.com/10.1097/CM9.0000000000002291 |
| work_keys_str_mv | AT qiaoyanliu intestinalhomeostasisinautoimmuneliverdiseases AT weihe intestinalhomeostasisinautoimmuneliverdiseases AT ruqitang intestinalhomeostasisinautoimmuneliverdiseases AT xiongma intestinalhomeostasisinautoimmuneliverdiseases AT yuanyuanji intestinalhomeostasisinautoimmuneliverdiseases |