Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells

Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells

Two novel peptides belonging to the dermaseptin family, namely DRS-CA-1 and DRS-DU-1, were encoded from cDNA libraries derived from the skin secretions of Phyllomedusa camba and Callimedusa (Phyllomedusa) duellmani. Both natural peptides are highly-conserved and exhibited high potency against wild-t...

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Bibliographic Details
Main Authors: Haohao Zhu, Xiyan Ding, Wei Li, Tulin Lu, Chengbang Ma, Xinping Xi, Lei Wang, Mei Zhou, Roberta Burden, Tianbao Chen
Format: Article
Language:English
Published: PeerJ Inc. 2018-09-01
Series:PeerJ
Subjects:
Molecular cloning
Skin secretion
Dermaseptin
Antimicrobial peptide
Cell viability.
Online Access:https://peerj.com/articles/5635.pdf

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