Background Parenchymal Enhancement and Fibroglandular Tissue Proportion on Breast MRI: Correlation with Hormone Receptor Expression and Molecular Subtypes of Breast Cancer
Objective:To assess the relationship between background parenchymal enhancement (BPE) and fibroglandular tissue (FGT) proportion on breast magnetic resonance imaging (MRI) and hormone receptor expression and molecular subtypes in invasive breast cancer. Materials and Methods:This retrospective study...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2017-01-01
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| Series: | European Journal of Breast Health |
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http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/background-parenchymal-enhancement-and-fibroglandu/42101
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| _version_ | 1828017867265671168 |
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| author | Mesut Öztürk Ahmet Veysel Polat Yurdanur Süllü Leman Tomak Ayfer Kamalı Polat |
| author_facet | Mesut Öztürk Ahmet Veysel Polat Yurdanur Süllü Leman Tomak Ayfer Kamalı Polat |
| author_sort | Mesut Öztürk |
| collection | DOAJ |
| description | Objective:To assess the relationship between background parenchymal enhancement (BPE) and fibroglandular tissue (FGT) proportion on breast magnetic resonance imaging (MRI) and hormone receptor expression and molecular subtypes in invasive breast cancer. Materials and Methods:This retrospective study enrolled 75 breast cancer patients who underwent breast MRI before treatment. T1-weighted images were reviewed to determine the FGT proportion, and contrast-enhanced fat-suppressed T1-weighted images were reviewed to determine BPE. Estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2-neu (HER2) status, and molecular subtypes of the tumors were compared with the BPE and FGT proportions.Results:Women with high BPE tended to have increased rate of ER and PR positive tumors (p=0.018 and p=0.013). FGT proportion was associated with ER positivity (p=0.009), but no significant differences between FGT proportion and PR positivity were found (p=0.256). There was no significant difference between HER2 status and any of the imaging features (p=0.453 and p=0.922). For premenopausal women, both FGT proportion and BPE were associated with molecular subtypes (p=0.025 and p=0.042). FGT proportion was also associated with BPE (p<0.001).Conclusion:In women with invasive breast cancer, both high FGT containing breasts and high BPE breasts tended to have ER positive tumors. |
| first_indexed | 2024-04-10T10:54:56Z |
| format | Article |
| id | doaj.art-0cc74994c9084c27b0f2410a60c41692 |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T10:54:56Z |
| publishDate | 2017-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-0cc74994c9084c27b0f2410a60c416922023-02-15T16:20:00ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312017-01-01131273310.5152/tjbh.2016.324713049054Background Parenchymal Enhancement and Fibroglandular Tissue Proportion on Breast MRI: Correlation with Hormone Receptor Expression and Molecular Subtypes of Breast CancerMesut Öztürk0Ahmet Veysel Polat1Yurdanur Süllü2Leman Tomak3Ayfer Kamalı Polat4 Department of Radiology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey Department of Radiology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey Department of Pathology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey Department of Medical Biostatistics, Ondokuz Mayıs University School of Medicine, Samsun, Turkey Department of General Surgery, Ondokuz Mayıs University School of Medicine, Samsun, Turkey Objective:To assess the relationship between background parenchymal enhancement (BPE) and fibroglandular tissue (FGT) proportion on breast magnetic resonance imaging (MRI) and hormone receptor expression and molecular subtypes in invasive breast cancer. Materials and Methods:This retrospective study enrolled 75 breast cancer patients who underwent breast MRI before treatment. T1-weighted images were reviewed to determine the FGT proportion, and contrast-enhanced fat-suppressed T1-weighted images were reviewed to determine BPE. Estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2-neu (HER2) status, and molecular subtypes of the tumors were compared with the BPE and FGT proportions.Results:Women with high BPE tended to have increased rate of ER and PR positive tumors (p=0.018 and p=0.013). FGT proportion was associated with ER positivity (p=0.009), but no significant differences between FGT proportion and PR positivity were found (p=0.256). There was no significant difference between HER2 status and any of the imaging features (p=0.453 and p=0.922). For premenopausal women, both FGT proportion and BPE were associated with molecular subtypes (p=0.025 and p=0.042). FGT proportion was also associated with BPE (p<0.001).Conclusion:In women with invasive breast cancer, both high FGT containing breasts and high BPE breasts tended to have ER positive tumors. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/background-parenchymal-enhancement-and-fibroglandu/42101 breast neoplasmsmagnetic resonance imagingmolecular subtypesenhancementhormone receptor |
| spellingShingle | Mesut Öztürk Ahmet Veysel Polat Yurdanur Süllü Leman Tomak Ayfer Kamalı Polat Background Parenchymal Enhancement and Fibroglandular Tissue Proportion on Breast MRI: Correlation with Hormone Receptor Expression and Molecular Subtypes of Breast Cancer European Journal of Breast Health breast neoplasms magnetic resonance imaging molecular subtypes enhancement hormone receptor |
| title | Background Parenchymal Enhancement and Fibroglandular Tissue Proportion on Breast MRI: Correlation with Hormone Receptor Expression and Molecular Subtypes of Breast Cancer |
| title_full | Background Parenchymal Enhancement and Fibroglandular Tissue Proportion on Breast MRI: Correlation with Hormone Receptor Expression and Molecular Subtypes of Breast Cancer |
| title_fullStr | Background Parenchymal Enhancement and Fibroglandular Tissue Proportion on Breast MRI: Correlation with Hormone Receptor Expression and Molecular Subtypes of Breast Cancer |
| title_full_unstemmed | Background Parenchymal Enhancement and Fibroglandular Tissue Proportion on Breast MRI: Correlation with Hormone Receptor Expression and Molecular Subtypes of Breast Cancer |
| title_short | Background Parenchymal Enhancement and Fibroglandular Tissue Proportion on Breast MRI: Correlation with Hormone Receptor Expression and Molecular Subtypes of Breast Cancer |
| title_sort | background parenchymal enhancement and fibroglandular tissue proportion on breast mri correlation with hormone receptor expression and molecular subtypes of breast cancer |
| topic | breast neoplasms magnetic resonance imaging molecular subtypes enhancement hormone receptor |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/background-parenchymal-enhancement-and-fibroglandu/42101
|
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