CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA
Background. During the study of the genetic variability of the tick-borne encephalitis virus (TBEV) in Eastern Siberia, a group of 22 strains with a unique genetic structure significantly different from all known TBEV subtypes was identified. This TBEV variant was tentatively called “group 886”....
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2018-07-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/650 |
| _version_ | 1797237314967044096 |
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| author | I. V. Kozlova T. V. Demina S. E. Tkachev E. K. Doroshchenko O. V. Lisak M. M. Verkhozina L. S. Karan Yu. P. Dzhioev A. I. Paramonov O. V. Suntsova Yu. S. Savinova O. O. Chernoivanova D. Ruzek N. V. Tikunova V. I. Zlobin |
| author_facet | I. V. Kozlova T. V. Demina S. E. Tkachev E. K. Doroshchenko O. V. Lisak M. M. Verkhozina L. S. Karan Yu. P. Dzhioev A. I. Paramonov O. V. Suntsova Yu. S. Savinova O. O. Chernoivanova D. Ruzek N. V. Tikunova V. I. Zlobin |
| author_sort | I. V. Kozlova |
| collection | DOAJ |
| description | Background. During the study of the genetic variability of the tick-borne encephalitis virus (TBEV) in Eastern Siberia, a group of 22 strains with a unique genetic structure significantly different from all known TBEV subtypes was identified. This TBEV variant was tentatively called “group 886”. Therefore, for this original TBEV variant it was necessary to study the genetic, biological properties of the “group 886” strains, clarify its TBEV taxonomic status, its range, evolutionary history, etc.Aim. The generalization of the currently available data on genetic and biological properties of TBEV “886” group.Materials and methods. The genetic structure of “group 886” strains was studied by the complex of molecular-genetic methods (MHNA, sequencing of fragments or the complete genome).Results. It was shown that “group 886” strains form a separate cluster on phylogenetic tree, and the level of genetic differences from other genotypes is more than 12 %. It was defined that this TBEV variant has its own area (Irkutsk region, Republic of Buryatia, Trans-Baikal region, Northern Mongolia). Its ecological connection with all links of the transmissive chain (ixodid ticks, small mammals, human), participation in human pathology, stability and duration of circulation in the Baikal region, individual evolutionary history were proved. Some phenotypic characteristics of the “group 886” strains were considered.Conclusion. The presented data testify to the validity of the “886 group” isolation as an independent genetic type. Taking into account the geographical distribution of this TBEV genotype, we propose to assign it the name “Baikal genotype/subtype”. |
| first_indexed | 2024-03-08T12:17:38Z |
| format | Article |
| id | doaj.art-0cc90dba0bc9402bb1b2681799ca13fb |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:17:47Z |
| publishDate | 2018-07-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-0cc90dba0bc9402bb1b2681799ca13fb2024-03-28T07:49:20ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962018-07-0134536010.29413/ABS.2018-3.4.9642CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIAI. V. Kozlova0T. V. Demina1S. E. Tkachev2E. K. Doroshchenko3O. V. Lisak4M. M. Verkhozina5L. S. Karan6Yu. P. Dzhioev7A. I. Paramonov8O. V. Suntsova9Yu. S. Savinova10O. O. Chernoivanova11D. Ruzek12N. V. Tikunova13V. I. Zlobin14Scientific Сentre for Family Health and Human Reproduction ProblemsIrkutsk State University of AgricultureInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of SciencesScientific Сentre for Family Health and Human Reproduction ProblemsIrkutsk State University of AgricultureCenter for Hygiene and Epidemiology in the Irkutsk RegionCentral Research Institute of EpidemiologyResearch Institute of Biomedical Technology of Irkutsk State Medical UniversityScientific Сentre for Family Health and Human Reproduction ProblemsScientific Сentre for Family Health and Human Reproduction ProblemsScientific Сentre for Family Health and Human Reproduction ProblemsScientific Сentre for Family Health and Human Reproduction ProblemsVeterinary Research InstituteCentral Research Institute of EpidemiologyResearch Institute of Biomedical Technology of Irkutsk State Medical UniversityBackground. During the study of the genetic variability of the tick-borne encephalitis virus (TBEV) in Eastern Siberia, a group of 22 strains with a unique genetic structure significantly different from all known TBEV subtypes was identified. This TBEV variant was tentatively called “group 886”. Therefore, for this original TBEV variant it was necessary to study the genetic, biological properties of the “group 886” strains, clarify its TBEV taxonomic status, its range, evolutionary history, etc.Aim. The generalization of the currently available data on genetic and biological properties of TBEV “886” group.Materials and methods. The genetic structure of “group 886” strains was studied by the complex of molecular-genetic methods (MHNA, sequencing of fragments or the complete genome).Results. It was shown that “group 886” strains form a separate cluster on phylogenetic tree, and the level of genetic differences from other genotypes is more than 12 %. It was defined that this TBEV variant has its own area (Irkutsk region, Republic of Buryatia, Trans-Baikal region, Northern Mongolia). Its ecological connection with all links of the transmissive chain (ixodid ticks, small mammals, human), participation in human pathology, stability and duration of circulation in the Baikal region, individual evolutionary history were proved. Some phenotypic characteristics of the “group 886” strains were considered.Conclusion. The presented data testify to the validity of the “886 group” isolation as an independent genetic type. Taking into account the geographical distribution of this TBEV genotype, we propose to assign it the name “Baikal genotype/subtype”.https://www.actabiomedica.ru/jour/article/view/650tick-born encephalitis virus (tbev)genotypesubtype |
| spellingShingle | I. V. Kozlova T. V. Demina S. E. Tkachev E. K. Doroshchenko O. V. Lisak M. M. Verkhozina L. S. Karan Yu. P. Dzhioev A. I. Paramonov O. V. Suntsova Yu. S. Savinova O. O. Chernoivanova D. Ruzek N. V. Tikunova V. I. Zlobin CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA Acta Biomedica Scientifica tick-born encephalitis virus (tbev) genotype subtype |
| title | CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA |
| title_full | CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA |
| title_fullStr | CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA |
| title_full_unstemmed | CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA |
| title_short | CHARACTERISTICS OF THE BAIKAL SUBTYPE OF TICK-BORNE ENCEPHALITIS VIRUS CIRCULATING IN EASTERN SIBERIA |
| title_sort | characteristics of the baikal subtype of tick borne encephalitis virus circulating in eastern siberia |
| topic | tick-born encephalitis virus (tbev) genotype subtype |
| url | https://www.actabiomedica.ru/jour/article/view/650 |
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