Telomere shortening and accelerated aging in COPD: findings from the BODE cohort
Abstract Background Chronic Obstructive Pulmonary Disease (COPD) may be associated with accelerated aging. Telomere shortening is a biomarker of aging. Cross-sectional studies describe shorter telomeres in COPD compared with matched controls. No studies have described telomere length trajectory and...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-04-01
|
| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12931-017-0547-4 |
| _version_ | 1830230548388249600 |
|---|---|
| author | Elizabeth Córdoba-Lanús Sara Cazorla-Rivero Adriana Espinoza-Jiménez Juan P. de-Torres María J. Pajares Armando Aguirre-Jaime Bartolomé Celli Ciro Casanova |
| author_facet | Elizabeth Córdoba-Lanús Sara Cazorla-Rivero Adriana Espinoza-Jiménez Juan P. de-Torres María J. Pajares Armando Aguirre-Jaime Bartolomé Celli Ciro Casanova |
| author_sort | Elizabeth Córdoba-Lanús |
| collection | DOAJ |
| description | Abstract Background Chronic Obstructive Pulmonary Disease (COPD) may be associated with accelerated aging. Telomere shortening is a biomarker of aging. Cross-sectional studies describe shorter telomeres in COPD compared with matched controls. No studies have described telomere length trajectory and its relationship with COPD progression. We investigated telomere shortening over time and its relationship to clinical and lung function parameters in a COPD cohort and smoker controls without COPD. Methods At baseline leukocyte telomere length was measured by qPCR in 121 smokers with COPD and 121 without COPD matched by age (T/S0). The measurements were repeated in 70 of those patients with COPD and 73 non-COPD smokers after 3 years of follow up (T/S3). Results At initial measurement, telomeres were shorter in COPD patients when compared to smoker controls (T/S = 0.68 ± 0.25 vs. 0.88 ± 0.52, p = 0.003) independent from age and sex. During the follow-up period, we observed an accelerated telomere shortening in individuals with COPD in contrast to smoker controls (T/S0 = 0.66 ± 0.21 vs. T/S3 = 0.46 ± 0.16, p < 0.001, for the patients with COPD and T/S0 = 0.83 ± 0.56 vs. T/S3 = 0.74 ± 0.52, p = 0.023 for controls; GLIM, p = 0.001). This shortening was inversely related to the baseline telomere length (r = −0.49, p < 0.001). No significant relationship was found between the rate of change in telomere length and change in lung function in the patients with COPD (p > 0.05). Conclusions Compared with smokers, patients with COPD have accelerated telomere shortening and this rate of attrition depends on baseline telomere length. Furthermore, the telomere length and its rate of shortening did not relate to clinical and lung function parameters changes over 3 years of follow-up. |
| first_indexed | 2024-12-18T10:56:34Z |
| format | Article |
| id | doaj.art-0cc961770620467f969285b8d3fbbd7c |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-18T10:56:34Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-0cc961770620467f969285b8d3fbbd7c2022-12-21T21:10:19ZengBMCRespiratory Research1465-993X2017-04-011811810.1186/s12931-017-0547-4Telomere shortening and accelerated aging in COPD: findings from the BODE cohortElizabeth Córdoba-Lanús0Sara Cazorla-Rivero1Adriana Espinoza-Jiménez2Juan P. de-Torres3María J. Pajares4Armando Aguirre-Jaime5Bartolomé Celli6Ciro Casanova7Research Unit, Hospital Universitario Nuestra Señora de CandelariaResearch Unit, Hospital Universitario Nuestra Señora de CandelariaResearch Unit, Hospital Universitario Nuestra Señora de CandelariaPulmonary Division, Clínica Universitaria de NavarraCentro de Investigación Médica Aplicada (CIMA), UNAVResearch Unit, Hospital Universitario Nuestra Señora de CandelariaPulmonary and Critical Care Department, Brigham and Women’s HospitalResearch Unit, Hospital Universitario Nuestra Señora de CandelariaAbstract Background Chronic Obstructive Pulmonary Disease (COPD) may be associated with accelerated aging. Telomere shortening is a biomarker of aging. Cross-sectional studies describe shorter telomeres in COPD compared with matched controls. No studies have described telomere length trajectory and its relationship with COPD progression. We investigated telomere shortening over time and its relationship to clinical and lung function parameters in a COPD cohort and smoker controls without COPD. Methods At baseline leukocyte telomere length was measured by qPCR in 121 smokers with COPD and 121 without COPD matched by age (T/S0). The measurements were repeated in 70 of those patients with COPD and 73 non-COPD smokers after 3 years of follow up (T/S3). Results At initial measurement, telomeres were shorter in COPD patients when compared to smoker controls (T/S = 0.68 ± 0.25 vs. 0.88 ± 0.52, p = 0.003) independent from age and sex. During the follow-up period, we observed an accelerated telomere shortening in individuals with COPD in contrast to smoker controls (T/S0 = 0.66 ± 0.21 vs. T/S3 = 0.46 ± 0.16, p < 0.001, for the patients with COPD and T/S0 = 0.83 ± 0.56 vs. T/S3 = 0.74 ± 0.52, p = 0.023 for controls; GLIM, p = 0.001). This shortening was inversely related to the baseline telomere length (r = −0.49, p < 0.001). No significant relationship was found between the rate of change in telomere length and change in lung function in the patients with COPD (p > 0.05). Conclusions Compared with smokers, patients with COPD have accelerated telomere shortening and this rate of attrition depends on baseline telomere length. Furthermore, the telomere length and its rate of shortening did not relate to clinical and lung function parameters changes over 3 years of follow-up.http://link.springer.com/article/10.1186/s12931-017-0547-4COPDTelomeresAging |
| spellingShingle | Elizabeth Córdoba-Lanús Sara Cazorla-Rivero Adriana Espinoza-Jiménez Juan P. de-Torres María J. Pajares Armando Aguirre-Jaime Bartolomé Celli Ciro Casanova Telomere shortening and accelerated aging in COPD: findings from the BODE cohort Respiratory Research COPD Telomeres Aging |
| title | Telomere shortening and accelerated aging in COPD: findings from the BODE cohort |
| title_full | Telomere shortening and accelerated aging in COPD: findings from the BODE cohort |
| title_fullStr | Telomere shortening and accelerated aging in COPD: findings from the BODE cohort |
| title_full_unstemmed | Telomere shortening and accelerated aging in COPD: findings from the BODE cohort |
| title_short | Telomere shortening and accelerated aging in COPD: findings from the BODE cohort |
| title_sort | telomere shortening and accelerated aging in copd findings from the bode cohort |
| topic | COPD Telomeres Aging |
| url | http://link.springer.com/article/10.1186/s12931-017-0547-4 |
| work_keys_str_mv | AT elizabethcordobalanus telomereshorteningandacceleratedagingincopdfindingsfromthebodecohort AT saracazorlarivero telomereshorteningandacceleratedagingincopdfindingsfromthebodecohort AT adrianaespinozajimenez telomereshorteningandacceleratedagingincopdfindingsfromthebodecohort AT juanpdetorres telomereshorteningandacceleratedagingincopdfindingsfromthebodecohort AT mariajpajares telomereshorteningandacceleratedagingincopdfindingsfromthebodecohort AT armandoaguirrejaime telomereshorteningandacceleratedagingincopdfindingsfromthebodecohort AT bartolomecelli telomereshorteningandacceleratedagingincopdfindingsfromthebodecohort AT cirocasanova telomereshorteningandacceleratedagingincopdfindingsfromthebodecohort |