Reference intervals of aortic pulse wave velocity assessed with an oscillometric device in healthy children and adolescents from Argentina
Age-related reference intervals (RIs) of aortic pulse wave velocity (Ao-PWV) obtained from a large healthy population are lacking in South America. The aims of this study were to determine Ao-PWV RIs in a cohort of healthy children and adolescents from Argentina and to generate year-to-year percenti...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-02-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | http://dx.doi.org/10.1080/10641963.2018.1445754 |
| _version_ | 1797681351627898880 |
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| author | Alejandro Díaz Yanina Zócalo Daniel Bia Franco Sabino Victoria Rodríguez Edmundo Ignacio Cabrera FIscher |
| author_facet | Alejandro Díaz Yanina Zócalo Daniel Bia Franco Sabino Victoria Rodríguez Edmundo Ignacio Cabrera FIscher |
| author_sort | Alejandro Díaz |
| collection | DOAJ |
| description | Age-related reference intervals (RIs) of aortic pulse wave velocity (Ao-PWV) obtained from a large healthy population are lacking in South America. The aims of this study were to determine Ao-PWV RIs in a cohort of healthy children and adolescents from Argentina and to generate year-to-year percentile curves. Ao-PWV was measured in 1000 healthy subjects non-exposed to traditional cardiovascular risk factors (Age: 10–22 y. o., 56% males). First, we evaluated if RIs for males and females were necessaries (correlation and covariate analysis). Second, mean (M) and standard deviation (SD) age-related equations were obtained for cf-PWV, using parametric regression methods based on fractional polynomials. Third, age-specific (year to year) percentiles curves (for all, males and females children and adolescents) were generated using the standard normal distribution. They were, age-specific 1st, 2.5th, 5th, 10th, 25th, 50th, 75th, 90th, 95th, 97.5th and 99th percentile curves and values. After covariate analysis (i.e., adjusting by age, jugulum-symphysis distance, body weight and height), specific RIs for males and females of children and adolescents were evidenced as necessaries. The equations were For all subjects: Ao-PWV_Mean = 4.98 + 12.86x10−5 Age3. Ao-PWV_SD = 0.47 + 21.00x10−6Age3. For girls: Ao-PWV_Mean = 5.07 + 10.23x10−5Age3. Ao-PWV_SD = 0.50 + 10.00x10−6Age3. For boys: Ao-PWV_Mean = 4.87 + 15.81x10−5Age3. Ao-PWV_SD = 0.46 + 22.34x10−6Age3. Our study provides the largest database to-date concerning Ao-PWV in healthy children and adolescents in Argentina. Age-related equations (M and SD values) for Ao-PWV are reported by the first time. Specific RIs and percentiles of Ao-PWV are now available according to age and sex for an Argentinian population. |
| first_indexed | 2024-03-11T23:43:37Z |
| format | Article |
| id | doaj.art-0cc98456446a4b0188472fdeaf442d47 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:37Z |
| publishDate | 2019-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-0cc98456446a4b0188472fdeaf442d472023-09-19T15:19:27ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062019-02-0141210111210.1080/10641963.2018.14457541445754Reference intervals of aortic pulse wave velocity assessed with an oscillometric device in healthy children and adolescents from ArgentinaAlejandro Díaz0Yanina Zócalo1Daniel Bia2Franco Sabino3Victoria Rodríguez4Edmundo Ignacio Cabrera FIscher5Instituto de Investigación en Ciencias de la Salud. UNICEN. CONICETCentro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic UniversityCentro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic UniversityInstituto de Investigación en Ciencias de la Salud. UNICEN. CONICETInstituto de Investigación en Ciencias de la Salud. UNICEN. CONICETInstituto de Medicina Traslacional, Trasplante y Bioingeniería - IMTTyB. Universidad Favaloro - CONICETAge-related reference intervals (RIs) of aortic pulse wave velocity (Ao-PWV) obtained from a large healthy population are lacking in South America. The aims of this study were to determine Ao-PWV RIs in a cohort of healthy children and adolescents from Argentina and to generate year-to-year percentile curves. Ao-PWV was measured in 1000 healthy subjects non-exposed to traditional cardiovascular risk factors (Age: 10–22 y. o., 56% males). First, we evaluated if RIs for males and females were necessaries (correlation and covariate analysis). Second, mean (M) and standard deviation (SD) age-related equations were obtained for cf-PWV, using parametric regression methods based on fractional polynomials. Third, age-specific (year to year) percentiles curves (for all, males and females children and adolescents) were generated using the standard normal distribution. They were, age-specific 1st, 2.5th, 5th, 10th, 25th, 50th, 75th, 90th, 95th, 97.5th and 99th percentile curves and values. After covariate analysis (i.e., adjusting by age, jugulum-symphysis distance, body weight and height), specific RIs for males and females of children and adolescents were evidenced as necessaries. The equations were For all subjects: Ao-PWV_Mean = 4.98 + 12.86x10−5 Age3. Ao-PWV_SD = 0.47 + 21.00x10−6Age3. For girls: Ao-PWV_Mean = 5.07 + 10.23x10−5Age3. Ao-PWV_SD = 0.50 + 10.00x10−6Age3. For boys: Ao-PWV_Mean = 4.87 + 15.81x10−5Age3. Ao-PWV_SD = 0.46 + 22.34x10−6Age3. Our study provides the largest database to-date concerning Ao-PWV in healthy children and adolescents in Argentina. Age-related equations (M and SD values) for Ao-PWV are reported by the first time. Specific RIs and percentiles of Ao-PWV are now available according to age and sex for an Argentinian population.http://dx.doi.org/10.1080/10641963.2018.1445754aortic pulse wave velocityarterial stiffnessreference intervalsepidemiologyadolescentschildren |
| spellingShingle | Alejandro Díaz Yanina Zócalo Daniel Bia Franco Sabino Victoria Rodríguez Edmundo Ignacio Cabrera FIscher Reference intervals of aortic pulse wave velocity assessed with an oscillometric device in healthy children and adolescents from Argentina Clinical and Experimental Hypertension aortic pulse wave velocity arterial stiffness reference intervals epidemiology adolescents children |
| title | Reference intervals of aortic pulse wave velocity assessed with an oscillometric device in healthy children and adolescents from Argentina |
| title_full | Reference intervals of aortic pulse wave velocity assessed with an oscillometric device in healthy children and adolescents from Argentina |
| title_fullStr | Reference intervals of aortic pulse wave velocity assessed with an oscillometric device in healthy children and adolescents from Argentina |
| title_full_unstemmed | Reference intervals of aortic pulse wave velocity assessed with an oscillometric device in healthy children and adolescents from Argentina |
| title_short | Reference intervals of aortic pulse wave velocity assessed with an oscillometric device in healthy children and adolescents from Argentina |
| title_sort | reference intervals of aortic pulse wave velocity assessed with an oscillometric device in healthy children and adolescents from argentina |
| topic | aortic pulse wave velocity arterial stiffness reference intervals epidemiology adolescents children |
| url | http://dx.doi.org/10.1080/10641963.2018.1445754 |
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