Biomodification Strategies for the Development of Antimicrobial Urinary Catheters: Overview and Advances
Abstract Microbial burden associated with medical devices poses serious health challenges and is accountable for an increased number of deaths leading to enormous medical costs. Catheter‐associated urinary tract infections are the most common hospital‐acquired infections with enhanced patient morbid...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Global Challenges |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/gch2.201700068 |
| _version_ | 1827866100071661568 |
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| author | Sadiya Anjum Surabhi Singh Lepoittevin Benedicte Philippe Roger Manoj Panigrahi Bhuvanesh Gupta |
| author_facet | Sadiya Anjum Surabhi Singh Lepoittevin Benedicte Philippe Roger Manoj Panigrahi Bhuvanesh Gupta |
| author_sort | Sadiya Anjum |
| collection | DOAJ |
| description | Abstract Microbial burden associated with medical devices poses serious health challenges and is accountable for an increased number of deaths leading to enormous medical costs. Catheter‐associated urinary tract infections are the most common hospital‐acquired infections with enhanced patient morbidity. Quite often, catheter‐associated bacteriuria produces apparent adverse outcomes such as urosepsis and even death. Taking this into account, the methods to modify urinary catheters to control microbial infections with relevance to clinical drug resistance are systematically evaluated in this review. Technologies to restrict biofilm formation at initial stages by using functional nanomaterials are elucidated. The conventional methodology of using single therapeutic intervention for developing an antimicrobial catheter lacks clinically meaningful benefit. Therefore, catheter modification using naturally derived antimicrobials such as essential oils, curcumin, enzymes, and antimicrobial peptides in combination with synthetic antibiotics/nanoantibiotics is likely to exert sufficient inhibitory effect on uropathogens and is extensively discussed. Futuristic efforts in this area are projected here that demand clinical studies to address areas of uncertainty to avoid development of bacterial resistance to the new generation therapy with minimum discomfort to the patients. |
| first_indexed | 2024-03-12T14:59:09Z |
| format | Article |
| id | doaj.art-0cca2020ff6c46f3a8f38e6fccce21b5 |
| institution | Directory Open Access Journal |
| issn | 2056-6646 |
| language | English |
| last_indexed | 2024-03-12T14:59:09Z |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Global Challenges |
| spelling | doaj.art-0cca2020ff6c46f3a8f38e6fccce21b52023-08-14T09:40:45ZengWileyGlobal Challenges2056-66462018-01-0121n/an/a10.1002/gch2.201700068Biomodification Strategies for the Development of Antimicrobial Urinary Catheters: Overview and AdvancesSadiya Anjum0Surabhi Singh1Lepoittevin Benedicte2Philippe Roger3Manoj Panigrahi4Bhuvanesh Gupta5Bioengineering Laboratory Department of Textile Technology Indian Institute of Technology New Delhi 110016 IndiaBioengineering Laboratory Department of Textile Technology Indian Institute of Technology New Delhi 110016 IndiaICMMO ‐ LG2M ‐ Bât 420 Université Paris‐Sud XI, 15 rue Georges Clémenceau 91405 Orsay Cedex FranceICMMO ‐ LG2M ‐ Bât 420 Université Paris‐Sud XI, 15 rue Georges Clémenceau 91405 Orsay Cedex FranceDepartment of Urology and Pathology Sikkim Manipal Institute of Medical Sciences Gangtok Sikkim 737101 IndiaBioengineering Laboratory Department of Textile Technology Indian Institute of Technology New Delhi 110016 IndiaAbstract Microbial burden associated with medical devices poses serious health challenges and is accountable for an increased number of deaths leading to enormous medical costs. Catheter‐associated urinary tract infections are the most common hospital‐acquired infections with enhanced patient morbidity. Quite often, catheter‐associated bacteriuria produces apparent adverse outcomes such as urosepsis and even death. Taking this into account, the methods to modify urinary catheters to control microbial infections with relevance to clinical drug resistance are systematically evaluated in this review. Technologies to restrict biofilm formation at initial stages by using functional nanomaterials are elucidated. The conventional methodology of using single therapeutic intervention for developing an antimicrobial catheter lacks clinically meaningful benefit. Therefore, catheter modification using naturally derived antimicrobials such as essential oils, curcumin, enzymes, and antimicrobial peptides in combination with synthetic antibiotics/nanoantibiotics is likely to exert sufficient inhibitory effect on uropathogens and is extensively discussed. Futuristic efforts in this area are projected here that demand clinical studies to address areas of uncertainty to avoid development of bacterial resistance to the new generation therapy with minimum discomfort to the patients.https://doi.org/10.1002/gch2.201700068antimicrobialbiofilmsfunctionalizationinfectionurinary catheters |
| spellingShingle | Sadiya Anjum Surabhi Singh Lepoittevin Benedicte Philippe Roger Manoj Panigrahi Bhuvanesh Gupta Biomodification Strategies for the Development of Antimicrobial Urinary Catheters: Overview and Advances Global Challenges antimicrobial biofilms functionalization infection urinary catheters |
| title | Biomodification Strategies for the Development of Antimicrobial Urinary Catheters: Overview and Advances |
| title_full | Biomodification Strategies for the Development of Antimicrobial Urinary Catheters: Overview and Advances |
| title_fullStr | Biomodification Strategies for the Development of Antimicrobial Urinary Catheters: Overview and Advances |
| title_full_unstemmed | Biomodification Strategies for the Development of Antimicrobial Urinary Catheters: Overview and Advances |
| title_short | Biomodification Strategies for the Development of Antimicrobial Urinary Catheters: Overview and Advances |
| title_sort | biomodification strategies for the development of antimicrobial urinary catheters overview and advances |
| topic | antimicrobial biofilms functionalization infection urinary catheters |
| url | https://doi.org/10.1002/gch2.201700068 |
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