Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study
Abstract The C4 sub-genotype of Enterovirus 71 (EV71) has been identified as the most dominant sub-genotype circulating in the Chinese mainland since 1998. The circulation situation of EV71 before 1998 is not well established due to insufficient experimental data. The C1 subgenotype of EV71 has not...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-022-01810-5 |
| _version_ | 1818008258792652800 |
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| author | Fenfen Si Dongyan Wang Tianjiao Ji Yong Zhang Shuangli Zhu Junhan Li Wenbo Xu Zexin Tao Dongmei Yan |
| author_facet | Fenfen Si Dongyan Wang Tianjiao Ji Yong Zhang Shuangli Zhu Junhan Li Wenbo Xu Zexin Tao Dongmei Yan |
| author_sort | Fenfen Si |
| collection | DOAJ |
| description | Abstract The C4 sub-genotype of Enterovirus 71 (EV71) has been identified as the most dominant sub-genotype circulating in the Chinese mainland since 1998. The circulation situation of EV71 before 1998 is not well established due to insufficient experimental data. The C1 subgenotype of EV71 has not yet been reported in the Chinese mainland by now. Based on the AFP surveillance system of the mainland of China, this study conducted a retrospective study of AFP cases for 1985–1999: a strain of EV-A71 C1 subgenotype was found. To our knowledge, this strain (SD92-41) is the first C1 sub-genotype reported in the Chinese mainland. This study demonstrates that the C1 gene subtype also appeared in the Chinese mainland, but it is unknown whether it is an imported or a local epidemic strain. With sufficient information known from retrospective studies, the source of the SD92-41 strain will be identified and the prevalence of EV-A71 in the Chinese mainland before 1998 will be clearer. |
| first_indexed | 2024-04-14T05:26:50Z |
| format | Article |
| id | doaj.art-0ccced9d6e70483a973de670b3ad94c8 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-14T05:26:50Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-0ccced9d6e70483a973de670b3ad94c82022-12-22T02:09:56ZengBMCVirology Journal1743-422X2022-05-011911510.1186/s12985-022-01810-5Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective studyFenfen Si0Dongyan Wang1Tianjiao Ji2Yong Zhang3Shuangli Zhu4Junhan Li5Wenbo Xu6Zexin Tao7Dongmei Yan8National Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionShandong Center for Disease Control and PreventionNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionAbstract The C4 sub-genotype of Enterovirus 71 (EV71) has been identified as the most dominant sub-genotype circulating in the Chinese mainland since 1998. The circulation situation of EV71 before 1998 is not well established due to insufficient experimental data. The C1 subgenotype of EV71 has not yet been reported in the Chinese mainland by now. Based on the AFP surveillance system of the mainland of China, this study conducted a retrospective study of AFP cases for 1985–1999: a strain of EV-A71 C1 subgenotype was found. To our knowledge, this strain (SD92-41) is the first C1 sub-genotype reported in the Chinese mainland. This study demonstrates that the C1 gene subtype also appeared in the Chinese mainland, but it is unknown whether it is an imported or a local epidemic strain. With sufficient information known from retrospective studies, the source of the SD92-41 strain will be identified and the prevalence of EV-A71 in the Chinese mainland before 1998 will be clearer.https://doi.org/10.1186/s12985-022-01810-5C1 sub-genotype of Enterovirus 71Retrospective studyGuillain–Barre syndromeAcute Flaccid Paralysis |
| spellingShingle | Fenfen Si Dongyan Wang Tianjiao Ji Yong Zhang Shuangli Zhu Junhan Li Wenbo Xu Zexin Tao Dongmei Yan Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study Virology Journal C1 sub-genotype of Enterovirus 71 Retrospective study Guillain–Barre syndrome Acute Flaccid Paralysis |
| title | Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study |
| title_full | Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study |
| title_fullStr | Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study |
| title_full_unstemmed | Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study |
| title_short | Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study |
| title_sort | identification of the first c1 subgenotype of enterovirus 71 in the chinese mainland in a retrospective study |
| topic | C1 sub-genotype of Enterovirus 71 Retrospective study Guillain–Barre syndrome Acute Flaccid Paralysis |
| url | https://doi.org/10.1186/s12985-022-01810-5 |
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