Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease: A case report
Dopaminergic medication for motor symptoms in Parkinson’s disease recently has been linked with impulse control disorders, including pathological gambling, which affects up to 8% of patients. Pathological gambling often is considered a behavioral addiction associated with disinhibition, risky decisi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-07-01
|
| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00095/full |
| _version_ | 1819117333123170304 |
|---|---|
| author | Mette Buhl Callesen Mette Buhl Callesen Kim Vang Hansen Albert eGjedde Albert eGjedde Jakob eLinnet Jakob eLinnet Arne eMøller Arne eMøller |
| author_facet | Mette Buhl Callesen Mette Buhl Callesen Kim Vang Hansen Albert eGjedde Albert eGjedde Jakob eLinnet Jakob eLinnet Arne eMøller Arne eMøller |
| author_sort | Mette Buhl Callesen |
| collection | DOAJ |
| description | Dopaminergic medication for motor symptoms in Parkinson’s disease recently has been linked with impulse control disorders, including pathological gambling, which affects up to 8% of patients. Pathological gambling often is considered a behavioral addiction associated with disinhibition, risky decision-making, and altered striatal dopaminergic neurotransmission. Using [11C]raclopride with positron emission tomography, we assessed dopaminergic neurotransmission during Iowa Gambling Task performance. Here we present data from a single patient with Parkinson’s disease and concomitant pathological gambling. We noted a marked decrease in [11C]raclopride binding in the left ventral striatum upon gambling, indicating a gambling-induced dopamine release. The results imply that pathological gambling in Parkinson’s disease is associated with a high dose of dopaminergic medication, pronounced motor symptomatology, young age at disease onset, high propensity for sensation seeking, and risky decision-making. Overall, the findings are consistent with the hypothesis of medication-related pathological gambling in Parkinson’s disease and underscore the importance of taking clinical variables, such as age and personality, into account when patients with Parkinson’s disease are medicated, to reduce the risk of pathological gambling. |
| first_indexed | 2024-12-22T05:31:19Z |
| format | Article |
| id | doaj.art-0cce93ecb6b243249a9c52f511f3ef68 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-22T05:31:19Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-0cce93ecb6b243249a9c52f511f3ef682022-12-21T18:37:27ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532013-07-01710.3389/fnbeh.2013.0009558575Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease: A case reportMette Buhl Callesen0Mette Buhl Callesen1Kim Vang Hansen2Albert eGjedde3Albert eGjedde4Jakob eLinnet5Jakob eLinnet6Arne eMøller7Arne eMøller8Aarhus University HospitalAarhus UniversityAarhus University HospitalAarhus University HospitalUniversity of CopenhagenAarhus UniversityAarhus UniversityAarhus University HospitalAarhus UniversityDopaminergic medication for motor symptoms in Parkinson’s disease recently has been linked with impulse control disorders, including pathological gambling, which affects up to 8% of patients. Pathological gambling often is considered a behavioral addiction associated with disinhibition, risky decision-making, and altered striatal dopaminergic neurotransmission. Using [11C]raclopride with positron emission tomography, we assessed dopaminergic neurotransmission during Iowa Gambling Task performance. Here we present data from a single patient with Parkinson’s disease and concomitant pathological gambling. We noted a marked decrease in [11C]raclopride binding in the left ventral striatum upon gambling, indicating a gambling-induced dopamine release. The results imply that pathological gambling in Parkinson’s disease is associated with a high dose of dopaminergic medication, pronounced motor symptomatology, young age at disease onset, high propensity for sensation seeking, and risky decision-making. Overall, the findings are consistent with the hypothesis of medication-related pathological gambling in Parkinson’s disease and underscore the importance of taking clinical variables, such as age and personality, into account when patients with Parkinson’s disease are medicated, to reduce the risk of pathological gambling.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00095/fullDecision MakingDopamineImpulse Control DisordersParkinson DiseasePathological Gambling |
| spellingShingle | Mette Buhl Callesen Mette Buhl Callesen Kim Vang Hansen Albert eGjedde Albert eGjedde Jakob eLinnet Jakob eLinnet Arne eMøller Arne eMøller Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease: A case report Frontiers in Behavioral Neuroscience Decision Making Dopamine Impulse Control Disorders Parkinson Disease Pathological Gambling |
| title | Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease: A case report |
| title_full | Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease: A case report |
| title_fullStr | Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease: A case report |
| title_full_unstemmed | Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease: A case report |
| title_short | Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease: A case report |
| title_sort | dopaminergic and clinical correlates of pathological gambling in parkinson 39 s disease a case report |
| topic | Decision Making Dopamine Impulse Control Disorders Parkinson Disease Pathological Gambling |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00095/full |
| work_keys_str_mv | AT mettebuhlcallesen dopaminergicandclinicalcorrelatesofpathologicalgamblinginparkinson39sdiseaseacasereport AT mettebuhlcallesen dopaminergicandclinicalcorrelatesofpathologicalgamblinginparkinson39sdiseaseacasereport AT kimvanghansen dopaminergicandclinicalcorrelatesofpathologicalgamblinginparkinson39sdiseaseacasereport AT albertegjedde dopaminergicandclinicalcorrelatesofpathologicalgamblinginparkinson39sdiseaseacasereport AT albertegjedde dopaminergicandclinicalcorrelatesofpathologicalgamblinginparkinson39sdiseaseacasereport AT jakobelinnet dopaminergicandclinicalcorrelatesofpathologicalgamblinginparkinson39sdiseaseacasereport AT jakobelinnet dopaminergicandclinicalcorrelatesofpathologicalgamblinginparkinson39sdiseaseacasereport AT arneemøller dopaminergicandclinicalcorrelatesofpathologicalgamblinginparkinson39sdiseaseacasereport AT arneemøller dopaminergicandclinicalcorrelatesofpathologicalgamblinginparkinson39sdiseaseacasereport |