Chromosomal aberrations in benign prostatic hyperplasia patients
Purpose: To investigate the chromosomal changes in patients with benign prostatic hyperplasia (BPH). Materials and Methods: A total of 54 patients diagnosed with clinical BPH underwent transurethral prostate resection to address their primary urological problem. All patients were evaluated by use...
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2016-01-01
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| Series: | Investigative and Clinical Urology |
| Subjects: | |
| Online Access: | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-57-45.pdf |
| _version_ | 1818563109762105344 |
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| author | Muammer Altok Özkan Bağcı Mehmet Umul Mustafa Güneş Mehmet Akyüz Fatih Uruç Efkan Uz Sedat Soyupek |
| author_facet | Muammer Altok Özkan Bağcı Mehmet Umul Mustafa Güneş Mehmet Akyüz Fatih Uruç Efkan Uz Sedat Soyupek |
| author_sort | Muammer Altok |
| collection | DOAJ |
| description | Purpose: To investigate the chromosomal changes in patients with benign prostatic hyperplasia (BPH).
Materials and Methods: A total of 54 patients diagnosed with clinical BPH underwent transurethral prostate resection to address
their primary urological problem. All patients were evaluated by use of a comprehensive medical history and rectal digital examination. The preoperative evaluation also included serum prostate-specific antigen (PSA) measurement and ultrasonographic measurement of prostate volume. Prostate cancer was detected in one patient, who was then excluded from the study. We performed conventional cytogenetic analyses of short-term cultures of 53 peripheral blood samples obtained from the BPH patients.
Results: The mean (±standard deviation) age of the 53 patients was 67.8±9.4 years. The mean PSA value of the patients was 5.8±7.0 ng/mL. The mean prostate volume was 53.6±22.9 mL. Chromosomal abnormalities were noted in 5 of the 53 cases (9.4%). Loss of the Y chromosome was the most frequent chromosomal abnormality and was observed in three patients (5.7%). There was no statistically significant relationship among age, PSA, prostate volume, and chromosomal changes.
Conclusions: Loss of the Y chromosome was the main chromosomal abnormality found in our study. However, this coexistence did not reach a significant level. Our study concluded that loss of the Y chromosome cannot be considered relevant for the diagnosis of BPH as it is for prostate cancer. Because BPH usually occurs in aging men, loss of the Y chromosome in BPH patients may instead be related to the aging process. |
| first_indexed | 2024-12-14T01:12:31Z |
| format | Article |
| id | doaj.art-0ccebaaa7fe54d728743bdc810a8e6c5 |
| institution | Directory Open Access Journal |
| issn | 2466-0493 2466-054X |
| language | English |
| last_indexed | 2024-12-14T01:12:31Z |
| publishDate | 2016-01-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj.art-0ccebaaa7fe54d728743bdc810a8e6c52022-12-21T23:22:41ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2016-01-01571454910.4111/icu.2016.57.1.45 Chromosomal aberrations in benign prostatic hyperplasia patientsMuammer Altok0Özkan Bağcı1Mehmet Umul2Mustafa Güneş3Mehmet Akyüz4Fatih Uruç5Efkan Uz6Sedat Soyupek7Süleyman Demirel UniversitySüleyman Demirel UniversitySüleyman Demirel UniversitySüleyman Demirel UniversityHaydarpaşa Numune Education and Research HospitalFatih Sultan Mehmet Education and Research HospitalSüleyman Demirel UniversitySüleyman Demirel UniversityPurpose: To investigate the chromosomal changes in patients with benign prostatic hyperplasia (BPH). Materials and Methods: A total of 54 patients diagnosed with clinical BPH underwent transurethral prostate resection to address their primary urological problem. All patients were evaluated by use of a comprehensive medical history and rectal digital examination. The preoperative evaluation also included serum prostate-specific antigen (PSA) measurement and ultrasonographic measurement of prostate volume. Prostate cancer was detected in one patient, who was then excluded from the study. We performed conventional cytogenetic analyses of short-term cultures of 53 peripheral blood samples obtained from the BPH patients. Results: The mean (±standard deviation) age of the 53 patients was 67.8±9.4 years. The mean PSA value of the patients was 5.8±7.0 ng/mL. The mean prostate volume was 53.6±22.9 mL. Chromosomal abnormalities were noted in 5 of the 53 cases (9.4%). Loss of the Y chromosome was the most frequent chromosomal abnormality and was observed in three patients (5.7%). There was no statistically significant relationship among age, PSA, prostate volume, and chromosomal changes. Conclusions: Loss of the Y chromosome was the main chromosomal abnormality found in our study. However, this coexistence did not reach a significant level. Our study concluded that loss of the Y chromosome cannot be considered relevant for the diagnosis of BPH as it is for prostate cancer. Because BPH usually occurs in aging men, loss of the Y chromosome in BPH patients may instead be related to the aging process.https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-57-45.pdfChromosomes; Genes; Hyperplasia; Prostate |
| spellingShingle | Muammer Altok Özkan Bağcı Mehmet Umul Mustafa Güneş Mehmet Akyüz Fatih Uruç Efkan Uz Sedat Soyupek Chromosomal aberrations in benign prostatic hyperplasia patients Investigative and Clinical Urology Chromosomes; Genes; Hyperplasia; Prostate |
| title | Chromosomal aberrations in benign prostatic hyperplasia patients |
| title_full | Chromosomal aberrations in benign prostatic hyperplasia patients |
| title_fullStr | Chromosomal aberrations in benign prostatic hyperplasia patients |
| title_full_unstemmed | Chromosomal aberrations in benign prostatic hyperplasia patients |
| title_short | Chromosomal aberrations in benign prostatic hyperplasia patients |
| title_sort | chromosomal aberrations in benign prostatic hyperplasia patients |
| topic | Chromosomes; Genes; Hyperplasia; Prostate |
| url | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-57-45.pdf |
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