Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin
Abstract The poison dart toxin batrachotoxin is exceptional for its high potency and toxicity, and for its multifaceted modification of the function of voltage-gated sodium channels. By using cryogenic electron microscopy, we identify two homologous, but nonidentical receptor sites that simultaneous...
Main Authors: | Lige Tonggu, Goragot Wisedchaisri, Tamer M. Gamal El-Din, Michael J. Lenaeus, Matthew M. Logan, Tatsuya Toma, Justin Du Bois, Ning Zheng, William A. Catterall |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-45958-w |
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