Effect of Glycyrrhiza Glabra and Vitamin C on Acrylamide-Induced Motor Dysfunction
Introduction: Acrylamide is a chemical compound which can be produced while frying carbohydrates in high- temperatures. Since the neurotoxicity of acrylamide was reported in the previous studies, the aim of the present study was to investigate the effects of co-administration of Glycyrrhiza Glabra...
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| Format: | Article |
| Language: | fas |
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Shahid Sadoughi University of Medical Sciences
2014-12-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| Subjects: | |
| Online Access: | http://jssu.ssu.ac.ir/browse.php?a_code=A-10-957-1&slc_lang=en&sid=1 |
| _version_ | 1811283417844678656 |
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| author | ME Rezvani A Mirgalili MH Dashti-Rahmatabadi AR Talebi |
| author_facet | ME Rezvani A Mirgalili MH Dashti-Rahmatabadi AR Talebi |
| author_sort | ME Rezvani |
| collection | DOAJ |
| description | Introduction: Acrylamide is a chemical compound which can be produced while frying carbohydrates in high- temperatures. Since the neurotoxicity of acrylamide was reported in the previous studies, the aim of the present study was to investigate the effects of co-administration of Glycyrrhiza Glabra and Vitamin C on acrylamide-induced weight loss and motor deficits in rats.
Methods: In this experimental study, 40 Wistar male rats aged 28 days were divided in to five groups of 8 rats including Control, Acrylamide, Acrylamide + Vitamin C, Acrylamide + Glycyrrhiza Glabra and Acrylamide +Vitamin C + Glycyrrhiza Glabra. All treatments were administered for 6 weeks. Thereafter, locomotor activity indices were measured using open field apparatus. In order to analyze the study data, One-way ANOVA followed by Tukey's test was used.
Results: The results showed that motor activity was significantly increased in vitamin C + Glycyrrhiza Glabra group compared with Acryl amide group. While treatment with vitamin C or Glycyrrhiza Glabra alone did not cause any significant changes in locomotor activity indices. In addition, rats treated with the combination of vitamin C and Glycyrrhiza Glabra significantly improved weight gain deficiency induced by Acrylamide .
Conclusion: The study findings revealed that the co-administration of vitamin C and Glycyrrhiza Glabra can retard the locomotor dysfunction and improve the weight gain in acrylamide-treated rats. |
| first_indexed | 2024-04-13T02:12:14Z |
| format | Article |
| id | doaj.art-0cd112db344e45d5a154d27a1e30c257 |
| institution | Directory Open Access Journal |
| issn | 2228-5741 2228-5733 |
| language | fas |
| last_indexed | 2024-04-13T02:12:14Z |
| publishDate | 2014-12-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
| spelling | doaj.art-0cd112db344e45d5a154d27a1e30c2572022-12-22T03:07:16ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332014-12-0122515671576Effect of Glycyrrhiza Glabra and Vitamin C on Acrylamide-Induced Motor DysfunctionME Rezvani0A Mirgalili1MH Dashti-Rahmatabadi2AR Talebi3 Shahid Sadoughi University of Medical Sciences Shahid Sadoughi University of Medical Sciences Shahid Sadoughi University of Medical Sciences Shahid Sadoughi University of Medical Sciences Introduction: Acrylamide is a chemical compound which can be produced while frying carbohydrates in high- temperatures. Since the neurotoxicity of acrylamide was reported in the previous studies, the aim of the present study was to investigate the effects of co-administration of Glycyrrhiza Glabra and Vitamin C on acrylamide-induced weight loss and motor deficits in rats. Methods: In this experimental study, 40 Wistar male rats aged 28 days were divided in to five groups of 8 rats including Control, Acrylamide, Acrylamide + Vitamin C, Acrylamide + Glycyrrhiza Glabra and Acrylamide +Vitamin C + Glycyrrhiza Glabra. All treatments were administered for 6 weeks. Thereafter, locomotor activity indices were measured using open field apparatus. In order to analyze the study data, One-way ANOVA followed by Tukey's test was used. Results: The results showed that motor activity was significantly increased in vitamin C + Glycyrrhiza Glabra group compared with Acryl amide group. While treatment with vitamin C or Glycyrrhiza Glabra alone did not cause any significant changes in locomotor activity indices. In addition, rats treated with the combination of vitamin C and Glycyrrhiza Glabra significantly improved weight gain deficiency induced by Acrylamide . Conclusion: The study findings revealed that the co-administration of vitamin C and Glycyrrhiza Glabra can retard the locomotor dysfunction and improve the weight gain in acrylamide-treated rats.http://jssu.ssu.ac.ir/browse.php?a_code=A-10-957-1&slc_lang=en&sid=1Acryl Amide Glycyrrhiza Glabra Open Field Test Rat Vitamin C Weight |
| spellingShingle | ME Rezvani A Mirgalili MH Dashti-Rahmatabadi AR Talebi Effect of Glycyrrhiza Glabra and Vitamin C on Acrylamide-Induced Motor Dysfunction Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd Acryl Amide Glycyrrhiza Glabra Open Field Test Rat Vitamin C Weight |
| title | Effect of Glycyrrhiza Glabra and Vitamin C on Acrylamide-Induced Motor Dysfunction |
| title_full | Effect of Glycyrrhiza Glabra and Vitamin C on Acrylamide-Induced Motor Dysfunction |
| title_fullStr | Effect of Glycyrrhiza Glabra and Vitamin C on Acrylamide-Induced Motor Dysfunction |
| title_full_unstemmed | Effect of Glycyrrhiza Glabra and Vitamin C on Acrylamide-Induced Motor Dysfunction |
| title_short | Effect of Glycyrrhiza Glabra and Vitamin C on Acrylamide-Induced Motor Dysfunction |
| title_sort | effect of glycyrrhiza glabra and vitamin c on acrylamide induced motor dysfunction |
| topic | Acryl Amide Glycyrrhiza Glabra Open Field Test Rat Vitamin C Weight |
| url | http://jssu.ssu.ac.ir/browse.php?a_code=A-10-957-1&slc_lang=en&sid=1 |
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