Assessment of zinc level and its relationship with some hematological parameters among patients with sickle cell anemia in Abakaliki, Nigeria
Background: Sickle cell anemia (SCA) is an inherited hemoglobin (Hb) disorder with susceptibility for oxidative damage due to chronic redox imbalance in red blood cells (RBCs) which often results in hemolysis, endothelial injury, recurrent vaso-occlusive episodes, and derangement in hematological pa...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
|
| Series: | Nigerian Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.njmonline.org/article.asp?issn=1115-2613;year=2021;volume=30;issue=1;spage=55;epage=59;aulast=Ugwu |
| _version_ | 1818613226978410496 |
|---|---|
| author | Ngozi Immaculata Ugwu Clifford Okike Collins N Ugwu Chinonyelum T Ezeonu Festus E Iyare Chihurumnanya Alo |
| author_facet | Ngozi Immaculata Ugwu Clifford Okike Collins N Ugwu Chinonyelum T Ezeonu Festus E Iyare Chihurumnanya Alo |
| author_sort | Ngozi Immaculata Ugwu |
| collection | DOAJ |
| description | Background: Sickle cell anemia (SCA) is an inherited hemoglobin (Hb) disorder with susceptibility for oxidative damage due to chronic redox imbalance in red blood cells (RBCs) which often results in hemolysis, endothelial injury, recurrent vaso-occlusive episodes, and derangement in hematological parameters. Zinc is an antioxidant which helps to reduce oxidative damage. This study aimed to assess the serum level of zinc and its relationship with some hematological parameters in patients with SCA (HbSS). Materials and Methods: This was a cross-sectional comparative study which involved HbSS patients in steady state with sex- and age-matched HbAA control. Assay of Hb phenotype, serum zinc level, and some haematological parameters were done. Ethical approval was gotten from the institutional review board, and each participant gave informed written consent before recruitment into the study. Analysis of all data obtained was done using SPSS software, version 20. Results: Thirty adult patients with SCA and thirty sex- and age-matched controls with a mean age of 26.7 ± 7.6 years and 27.7± 5.3, respectively, were studied. There was a significant decrease in serum zinc level among patients with HbSS compared to those with HbAA (P = 0.038). Similarly, patients with HbSS had significantly lower Hb level, packed cell volume, and RBC count compared to HbAA control (P < 0.05). On the contrary, patients with HbSS had significantly higher white cell count and platelet count compared to HbAA individuals (P < 0.05). Correlation between serum zinc level and blood counts showed weak positive relationship between zinc level and Hb level (r = 0.04, P = 0.8) and weak negative relationship between serum zinc level and platelet count (r = −0.3, P = 0.1), as well as zinc and white blood cell (WBC) count (r = −0.2, P = 0.4). Conclusion: There was a significantly low level of zinc among patients with HbSS compared with HbAA controls. Patients with HbSS had zinc levels that weakly correlated with Hb level positively but weakly negatively correlated with platelet and WBC counts. Further studies are required on a wider scale to assess whether zinc supplementation may improve blood counts in patients with SCA. |
| first_indexed | 2024-12-16T15:58:46Z |
| format | Article |
| id | doaj.art-0cd22202ac4b47a5ad350775e775b048 |
| institution | Directory Open Access Journal |
| issn | 1115-2613 |
| language | English |
| last_indexed | 2024-12-16T15:58:46Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Nigerian Journal of Medicine |
| spelling | doaj.art-0cd22202ac4b47a5ad350775e775b0482022-12-21T22:25:30ZengWolters Kluwer Medknow PublicationsNigerian Journal of Medicine1115-26132021-01-01301555910.4103/NJM.NJM_178_20Assessment of zinc level and its relationship with some hematological parameters among patients with sickle cell anemia in Abakaliki, NigeriaNgozi Immaculata UgwuClifford OkikeCollins N UgwuChinonyelum T EzeonuFestus E IyareChihurumnanya AloBackground: Sickle cell anemia (SCA) is an inherited hemoglobin (Hb) disorder with susceptibility for oxidative damage due to chronic redox imbalance in red blood cells (RBCs) which often results in hemolysis, endothelial injury, recurrent vaso-occlusive episodes, and derangement in hematological parameters. Zinc is an antioxidant which helps to reduce oxidative damage. This study aimed to assess the serum level of zinc and its relationship with some hematological parameters in patients with SCA (HbSS). Materials and Methods: This was a cross-sectional comparative study which involved HbSS patients in steady state with sex- and age-matched HbAA control. Assay of Hb phenotype, serum zinc level, and some haematological parameters were done. Ethical approval was gotten from the institutional review board, and each participant gave informed written consent before recruitment into the study. Analysis of all data obtained was done using SPSS software, version 20. Results: Thirty adult patients with SCA and thirty sex- and age-matched controls with a mean age of 26.7 ± 7.6 years and 27.7± 5.3, respectively, were studied. There was a significant decrease in serum zinc level among patients with HbSS compared to those with HbAA (P = 0.038). Similarly, patients with HbSS had significantly lower Hb level, packed cell volume, and RBC count compared to HbAA control (P < 0.05). On the contrary, patients with HbSS had significantly higher white cell count and platelet count compared to HbAA individuals (P < 0.05). Correlation between serum zinc level and blood counts showed weak positive relationship between zinc level and Hb level (r = 0.04, P = 0.8) and weak negative relationship between serum zinc level and platelet count (r = −0.3, P = 0.1), as well as zinc and white blood cell (WBC) count (r = −0.2, P = 0.4). Conclusion: There was a significantly low level of zinc among patients with HbSS compared with HbAA controls. Patients with HbSS had zinc levels that weakly correlated with Hb level positively but weakly negatively correlated with platelet and WBC counts. Further studies are required on a wider scale to assess whether zinc supplementation may improve blood counts in patients with SCA.http://www.njmonline.org/article.asp?issn=1115-2613;year=2021;volume=30;issue=1;spage=55;epage=59;aulast=Ugwuhematological parametersred blood cellsickle cell anemiazinc level |
| spellingShingle | Ngozi Immaculata Ugwu Clifford Okike Collins N Ugwu Chinonyelum T Ezeonu Festus E Iyare Chihurumnanya Alo Assessment of zinc level and its relationship with some hematological parameters among patients with sickle cell anemia in Abakaliki, Nigeria Nigerian Journal of Medicine hematological parameters red blood cell sickle cell anemia zinc level |
| title | Assessment of zinc level and its relationship with some hematological parameters among patients with sickle cell anemia in Abakaliki, Nigeria |
| title_full | Assessment of zinc level and its relationship with some hematological parameters among patients with sickle cell anemia in Abakaliki, Nigeria |
| title_fullStr | Assessment of zinc level and its relationship with some hematological parameters among patients with sickle cell anemia in Abakaliki, Nigeria |
| title_full_unstemmed | Assessment of zinc level and its relationship with some hematological parameters among patients with sickle cell anemia in Abakaliki, Nigeria |
| title_short | Assessment of zinc level and its relationship with some hematological parameters among patients with sickle cell anemia in Abakaliki, Nigeria |
| title_sort | assessment of zinc level and its relationship with some hematological parameters among patients with sickle cell anemia in abakaliki nigeria |
| topic | hematological parameters red blood cell sickle cell anemia zinc level |
| url | http://www.njmonline.org/article.asp?issn=1115-2613;year=2021;volume=30;issue=1;spage=55;epage=59;aulast=Ugwu |
| work_keys_str_mv | AT ngoziimmaculataugwu assessmentofzinclevelanditsrelationshipwithsomehematologicalparametersamongpatientswithsicklecellanemiainabakalikinigeria AT cliffordokike assessmentofzinclevelanditsrelationshipwithsomehematologicalparametersamongpatientswithsicklecellanemiainabakalikinigeria AT collinsnugwu assessmentofzinclevelanditsrelationshipwithsomehematologicalparametersamongpatientswithsicklecellanemiainabakalikinigeria AT chinonyelumtezeonu assessmentofzinclevelanditsrelationshipwithsomehematologicalparametersamongpatientswithsicklecellanemiainabakalikinigeria AT festuseiyare assessmentofzinclevelanditsrelationshipwithsomehematologicalparametersamongpatientswithsicklecellanemiainabakalikinigeria AT chihurumnanyaalo assessmentofzinclevelanditsrelationshipwithsomehematologicalparametersamongpatientswithsicklecellanemiainabakalikinigeria |