Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex
Objective(s): Methamphetamine is a stimulant compound that penetrates readily into the central nervous system. Repeated exposure to methamphetamine leads to damage in the dopaminergic and serotonergic axons of selected brain regions. Previous studies showed that cinnamaldehyde improved memory impair...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2018-12-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | http://ijbms.mums.ac.ir/article_11776_34ca662a4091aa12022c9a0bb6e9fad2.pdf |
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| author | Mohammad Saeed Ameneh Ghadiri Farzin Hadizadeh Armin Attaranzadeh Mohaddeseh Sadat Alavi Leila Etemad |
| author_facet | Mohammad Saeed Ameneh Ghadiri Farzin Hadizadeh Armin Attaranzadeh Mohaddeseh Sadat Alavi Leila Etemad |
| author_sort | Mohammad Saeed |
| collection | DOAJ |
| description | Objective(s): Methamphetamine is a stimulant compound that penetrates readily into the central nervous system. Repeated exposure to methamphetamine leads to damage in the dopaminergic and serotonergic axons of selected brain regions. Previous studies showed that cinnamaldehyde improved memory impairment in animals. In the present study, we aimed to elucidate the effects of cinnamaldehyde on methamphetamine-induced memory impairment in rats. Materials and Methods: Male Wistar rats received methamphetamine (10 mg/kg, intraperitoneally) for 7 days. Thirty minutes before each injection, animals were given cinnamaldehyde (20, 40, or 80 mg/kg) or rivastigmine (1 mg/kg). The spatial learning and memory were examined using the Morris water maze test. The expression of extracellular signal-regulated kinase (ERK) phosphorylation in the frontal cortex and hippocampus was also detected by immunohistochemical method.Results: Administration of methamphetamine increased the latency to find the platform in the learning phase, while administration of cinnamaldehyde (40 mg/kg) or rivastigmine before methamphetamine reversed the increased latency. Administration of cinnamaldehyde, at the dose of 40 mg/kg with methamphetamine, increased the time and distance traveled in the target quadrant in comparison with the amphetamine group. Moreover, the methamphetamine and cinnamaldehyde-treated group had higher expression of phosphorylated ERK1/2 in the prefrontal cortex in comparison with the methamphetamine-treated animals.Conclusion: The present data demonstrated that repeated METH administration impaired cognitive performance through the ERK pathway and decreased the phosphorylation of ERK1/2 in the prefrontal cortex while administration of cinnamaldehyde restored both effects. Accordingly, cinnamaldehyde may be a valuable therapeutic tool for the treatment of cognitive deficits associated with methamphetamine consumption. |
| first_indexed | 2024-12-12T04:52:47Z |
| format | Article |
| id | doaj.art-0cd2bc3d467140699e14c23bd6e510e7 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-12T04:52:47Z |
| publishDate | 2018-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-0cd2bc3d467140699e14c23bd6e510e72022-12-22T00:37:26ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742018-12-0121121316132110.22038/ijbms.2018.35368.842711776Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortexMohammad Saeed0Ameneh Ghadiri1Farzin Hadizadeh2Armin Attaranzadeh3Mohaddeseh Sadat Alavi4Leila Etemad5School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, ItalyBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranMilad Infertility Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IranDivision of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranObjective(s): Methamphetamine is a stimulant compound that penetrates readily into the central nervous system. Repeated exposure to methamphetamine leads to damage in the dopaminergic and serotonergic axons of selected brain regions. Previous studies showed that cinnamaldehyde improved memory impairment in animals. In the present study, we aimed to elucidate the effects of cinnamaldehyde on methamphetamine-induced memory impairment in rats. Materials and Methods: Male Wistar rats received methamphetamine (10 mg/kg, intraperitoneally) for 7 days. Thirty minutes before each injection, animals were given cinnamaldehyde (20, 40, or 80 mg/kg) or rivastigmine (1 mg/kg). The spatial learning and memory were examined using the Morris water maze test. The expression of extracellular signal-regulated kinase (ERK) phosphorylation in the frontal cortex and hippocampus was also detected by immunohistochemical method.Results: Administration of methamphetamine increased the latency to find the platform in the learning phase, while administration of cinnamaldehyde (40 mg/kg) or rivastigmine before methamphetamine reversed the increased latency. Administration of cinnamaldehyde, at the dose of 40 mg/kg with methamphetamine, increased the time and distance traveled in the target quadrant in comparison with the amphetamine group. Moreover, the methamphetamine and cinnamaldehyde-treated group had higher expression of phosphorylated ERK1/2 in the prefrontal cortex in comparison with the methamphetamine-treated animals.Conclusion: The present data demonstrated that repeated METH administration impaired cognitive performance through the ERK pathway and decreased the phosphorylation of ERK1/2 in the prefrontal cortex while administration of cinnamaldehyde restored both effects. Accordingly, cinnamaldehyde may be a valuable therapeutic tool for the treatment of cognitive deficits associated with methamphetamine consumption.http://ijbms.mums.ac.ir/article_11776_34ca662a4091aa12022c9a0bb6e9fad2.pdfCinnamaldehydeERK1/2Learning deficitMemory deficitMethamphetamine |
| spellingShingle | Mohammad Saeed Ameneh Ghadiri Farzin Hadizadeh Armin Attaranzadeh Mohaddeseh Sadat Alavi Leila Etemad Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex Iranian Journal of Basic Medical Sciences Cinnamaldehyde ERK1/2 Learning deficit Memory deficit Methamphetamine |
| title | Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex |
| title_full | Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex |
| title_fullStr | Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex |
| title_full_unstemmed | Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex |
| title_short | Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex |
| title_sort | cinnamaldehyde improves methamphetamine induced spatial learning and memory deficits and restores erk signaling in the rat prefrontal cortex |
| topic | Cinnamaldehyde ERK1/2 Learning deficit Memory deficit Methamphetamine |
| url | http://ijbms.mums.ac.ir/article_11776_34ca662a4091aa12022c9a0bb6e9fad2.pdf |
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