The Occurrence of Atopy in Patients with Isolated Spontaneous Mast Cell (or Nonallergic) Angioedema
Background: Isolated mast cell angioedema (MC-AE) can be divided into allergic and nonallergic (spontaneous) forms. The former is often associated with food, Hymenoptera venoms or drug allergies. This study aimed to evaluate the relationship between the occurrence of atopic diseases and the risk of...
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/2/477 |
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| author | Magdalena Zajac Andrzej Bozek Alicja Grzanka |
| author_facet | Magdalena Zajac Andrzej Bozek Alicja Grzanka |
| author_sort | Magdalena Zajac |
| collection | DOAJ |
| description | Background: Isolated mast cell angioedema (MC-AE) can be divided into allergic and nonallergic (spontaneous) forms. The former is often associated with food, Hymenoptera venoms or drug allergies. This study aimed to evaluate the relationship between the occurrence of atopic diseases and the risk of angioedema. Methods: A retrospective study analyzed 304 patients with confirmed MC-AE and 1066 controls. All were analyzed for allergic asthma (AA), atopic dermatitis (AD) and allergic rhinitis (AR) based on ICD-10 codes. In addition, total IgE and peripheral eosinophilia were calculated. Results: The analyzed atopic diseases were more frequent in the group of patients diagnosed with MC-AE than in the controls: 78 (25.7%) vs. 173 (16.2%) for <i>p</i> < 0.01. Patients diagnosed with AD had a higher risk of MC-AE (hazard ratio (HR) = 1.48,) similar to those diagnosed with AR (HR = 1.51). However, in patients with two or three atopic comorbidities, the risk increased significantly to HR = 2.45 or HR = 4.1, respectively. There was a positive correlation between the serum total IgE concentration or eosinophilia and the risk of angioedema (<i>p</i> < 0.01). Conclusion: Patients with MC-AE had a more frequent occurrence of atopic diseases associated with inhalant allergies. This risk increased in patients with IgE-mediated polymorphic disease. |
| first_indexed | 2024-03-08T09:51:34Z |
| format | Article |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T09:51:34Z |
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| spelling | doaj.art-0cd2f73d17e8441d9dab407e093b75622024-01-29T14:02:11ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113247710.3390/jcm13020477The Occurrence of Atopy in Patients with Isolated Spontaneous Mast Cell (or Nonallergic) AngioedemaMagdalena Zajac0Andrzej Bozek1Alicja Grzanka2Clinical Department of Internal Diseases, Dermatology and Allergology, Medical University of Silesia, 40-055 Katowice, PolandClinical Department of Internal Diseases, Dermatology and Allergology, Medical University of Silesia, 40-055 Katowice, PolandClinical Department of Internal Diseases, Dermatology and Allergology, Medical University of Silesia, 40-055 Katowice, PolandBackground: Isolated mast cell angioedema (MC-AE) can be divided into allergic and nonallergic (spontaneous) forms. The former is often associated with food, Hymenoptera venoms or drug allergies. This study aimed to evaluate the relationship between the occurrence of atopic diseases and the risk of angioedema. Methods: A retrospective study analyzed 304 patients with confirmed MC-AE and 1066 controls. All were analyzed for allergic asthma (AA), atopic dermatitis (AD) and allergic rhinitis (AR) based on ICD-10 codes. In addition, total IgE and peripheral eosinophilia were calculated. Results: The analyzed atopic diseases were more frequent in the group of patients diagnosed with MC-AE than in the controls: 78 (25.7%) vs. 173 (16.2%) for <i>p</i> < 0.01. Patients diagnosed with AD had a higher risk of MC-AE (hazard ratio (HR) = 1.48,) similar to those diagnosed with AR (HR = 1.51). However, in patients with two or three atopic comorbidities, the risk increased significantly to HR = 2.45 or HR = 4.1, respectively. There was a positive correlation between the serum total IgE concentration or eosinophilia and the risk of angioedema (<i>p</i> < 0.01). Conclusion: Patients with MC-AE had a more frequent occurrence of atopic diseases associated with inhalant allergies. This risk increased in patients with IgE-mediated polymorphic disease.https://www.mdpi.com/2077-0383/13/2/477angioedemaIgEallergic rhinitisatopic dermatitis |
| spellingShingle | Magdalena Zajac Andrzej Bozek Alicja Grzanka The Occurrence of Atopy in Patients with Isolated Spontaneous Mast Cell (or Nonallergic) Angioedema Journal of Clinical Medicine angioedema IgE allergic rhinitis atopic dermatitis |
| title | The Occurrence of Atopy in Patients with Isolated Spontaneous Mast Cell (or Nonallergic) Angioedema |
| title_full | The Occurrence of Atopy in Patients with Isolated Spontaneous Mast Cell (or Nonallergic) Angioedema |
| title_fullStr | The Occurrence of Atopy in Patients with Isolated Spontaneous Mast Cell (or Nonallergic) Angioedema |
| title_full_unstemmed | The Occurrence of Atopy in Patients with Isolated Spontaneous Mast Cell (or Nonallergic) Angioedema |
| title_short | The Occurrence of Atopy in Patients with Isolated Spontaneous Mast Cell (or Nonallergic) Angioedema |
| title_sort | occurrence of atopy in patients with isolated spontaneous mast cell or nonallergic angioedema |
| topic | angioedema IgE allergic rhinitis atopic dermatitis |
| url | https://www.mdpi.com/2077-0383/13/2/477 |
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