Increase in endoplasmic reticulum-associated tissue transglutaminase and enzymatic activation in a cellular model of Parkinson's disease

Increase in endoplasmic reticulum-associated tissue transglutaminase and enzymatic activation in a cellular model of Parkinson's disease

Parkinson's disease (PD) is characterized by accumulation of α-synuclein aggregates and degeneration of melanized, catecholaminergic neurons. The tissue transglutaminase (tTG) enzyme catalyzes molecular protein cross-linking. In PD, tTG levels are increased and cross-linking has been identified...

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Bibliographic Details
Main Authors: Robin Verhaar, Benjamin Drukarch, John G.J.M. Bol, Cornelis A.M. Jongenelen, René J.P. Musters, Micha M.M. Wilhelmus
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
Tissue transglutaminase
Parkinson's disease
SH-SY5Y
ER
Neuroblastoma
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003445

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