Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants
Biological membranes are predominantly composed of structural glycerophospholipids such as phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol. Of the membrane glycerophospholipids, phosphatidylinositol (PtdIns) and its phosphorylated derivatives (phosphoinositides) constitute a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpls.2019.00274/full |
| _version_ | 1828241939946799104 |
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| author | Tomoko Hirano Masa H. Sato |
| author_facet | Tomoko Hirano Masa H. Sato |
| author_sort | Tomoko Hirano |
| collection | DOAJ |
| description | Biological membranes are predominantly composed of structural glycerophospholipids such as phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol. Of the membrane glycerophospholipids, phosphatidylinositol (PtdIns) and its phosphorylated derivatives (phosphoinositides) constitute a minor fraction yet exert a wide variety of regulatory functions in eukaryotic cells. Phosphoinositides include PtdIns, three PtdIns monophosphates, three PtdIns bisphosphates, and one PtdIns triphosphate, in which the hydroxy groups of the inositol head group of PtdIns are phosphorylated by specific lipid kinases. Of all the phosphoinositides in eukaryotic cells, phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2] constitutes the smallest fraction, yet it is a crucial lipid in animal and yeast membrane trafficking systems. Here, we review the recent findings on the physiological functions of PtdIns(3,5)P2 and its enzyme—formation of aploid and binucleate cells (FAB1)—along with the regulatory proteins of FAB1 and the downstream effector proteins of PtdIns(3,5)P2 in Arabidopsis. |
| first_indexed | 2024-04-12T22:07:06Z |
| format | Article |
| id | doaj.art-0cd6cd3097a74701b3132cadfe5157b8 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-04-12T22:07:06Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-0cd6cd3097a74701b3132cadfe5157b82022-12-22T03:14:53ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2019-03-011010.3389/fpls.2019.00274441461Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in PlantsTomoko HiranoMasa H. SatoBiological membranes are predominantly composed of structural glycerophospholipids such as phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol. Of the membrane glycerophospholipids, phosphatidylinositol (PtdIns) and its phosphorylated derivatives (phosphoinositides) constitute a minor fraction yet exert a wide variety of regulatory functions in eukaryotic cells. Phosphoinositides include PtdIns, three PtdIns monophosphates, three PtdIns bisphosphates, and one PtdIns triphosphate, in which the hydroxy groups of the inositol head group of PtdIns are phosphorylated by specific lipid kinases. Of all the phosphoinositides in eukaryotic cells, phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2] constitutes the smallest fraction, yet it is a crucial lipid in animal and yeast membrane trafficking systems. Here, we review the recent findings on the physiological functions of PtdIns(3,5)P2 and its enzyme—formation of aploid and binucleate cells (FAB1)—along with the regulatory proteins of FAB1 and the downstream effector proteins of PtdIns(3,5)P2 in Arabidopsis.https://www.frontiersin.org/article/10.3389/fpls.2019.00274/fullArabidopsisphosphoinositidesbiological membranesPtdIns(3,5)P2PtdIns-binding proteins |
| spellingShingle | Tomoko Hirano Masa H. Sato Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants Frontiers in Plant Science Arabidopsis phosphoinositides biological membranes PtdIns(3,5)P2 PtdIns-binding proteins |
| title | Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants |
| title_full | Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants |
| title_fullStr | Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants |
| title_full_unstemmed | Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants |
| title_short | Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants |
| title_sort | diverse physiological functions of fab1 and phosphatidylinositol 3 5 bisphosphate in plants |
| topic | Arabidopsis phosphoinositides biological membranes PtdIns(3,5)P2 PtdIns-binding proteins |
| url | https://www.frontiersin.org/article/10.3389/fpls.2019.00274/full |
| work_keys_str_mv | AT tomokohirano diversephysiologicalfunctionsoffab1andphosphatidylinositol35bisphosphateinplants AT masahsato diversephysiologicalfunctionsoffab1andphosphatidylinositol35bisphosphateinplants |