Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles
Mast cells (MCs) are strategically located in tissues close to the external environment, being one of the first immune cells to interact with invading pathogens. They are long living effector cells equipped with different receptors that allow microbial recognition. Once activated, MCs release numero...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-06-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.685865/full |
| _version_ | 1819103251349372928 |
|---|---|
| author | Mariela Jiménez Daniel Cervantes-García Daniel Cervantes-García Laura E. Córdova-Dávalos Marian Jesabel Pérez-Rodríguez Claudia Gonzalez-Espinosa Eva Salinas |
| author_facet | Mariela Jiménez Daniel Cervantes-García Daniel Cervantes-García Laura E. Córdova-Dávalos Marian Jesabel Pérez-Rodríguez Claudia Gonzalez-Espinosa Eva Salinas |
| author_sort | Mariela Jiménez |
| collection | DOAJ |
| description | Mast cells (MCs) are strategically located in tissues close to the external environment, being one of the first immune cells to interact with invading pathogens. They are long living effector cells equipped with different receptors that allow microbial recognition. Once activated, MCs release numerous biologically active mediators in the site of pathogen contact, which induce vascular endothelium modification, inflammation development and extracellular matrix remodeling. Efficient and direct antimicrobial mechanisms of MCs involve phagocytosis with oxidative and non-oxidative microbial destruction, extracellular trap formation, and the release of antimicrobial substances. MCs also contribute to host defense through the attraction and activation of phagocytic and inflammatory cells, shaping the innate and adaptive immune responses. However, as part of their response to pathogens and under an impaired, sustained, or systemic activation, MCs may contribute to tissue damage. This review will focus on the current knowledge about direct and indirect contribution of MCs to pathogen clearance. Antimicrobial mechanisms of MCs are addressed with special attention to signaling pathways involved and molecular weapons implicated. The role of MCs in a dysregulated host response that can increase morbidity and mortality is also reviewed and discussed, highlighting the complexity of MCs biology in the context of host-pathogen interactions. |
| first_indexed | 2024-12-22T01:47:29Z |
| format | Article |
| id | doaj.art-0cd7399792284167afdeecec6824b609 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T01:47:29Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0cd7399792284167afdeecec6824b6092022-12-21T18:43:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-06-011210.3389/fimmu.2021.685865685865Responses of Mast Cells to Pathogens: Beneficial and Detrimental RolesMariela Jiménez0Daniel Cervantes-García1Daniel Cervantes-García2Laura E. Córdova-Dávalos3Marian Jesabel Pérez-Rodríguez4Claudia Gonzalez-Espinosa5Eva Salinas6Laboratory of Immunology, Department of Microbiology, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoLaboratory of Immunology, Department of Microbiology, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoCátedras CONACYT, National Council of Science and Technology, Mexico City, MexicoLaboratory of Immunology, Department of Microbiology, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoDepartment of Pharmacobiology, Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur, Mexico City, MexicoDepartment of Pharmacobiology, Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur, Mexico City, MexicoLaboratory of Immunology, Department of Microbiology, Universidad Autónoma de Aguascalientes, Aguascalientes, MexicoMast cells (MCs) are strategically located in tissues close to the external environment, being one of the first immune cells to interact with invading pathogens. They are long living effector cells equipped with different receptors that allow microbial recognition. Once activated, MCs release numerous biologically active mediators in the site of pathogen contact, which induce vascular endothelium modification, inflammation development and extracellular matrix remodeling. Efficient and direct antimicrobial mechanisms of MCs involve phagocytosis with oxidative and non-oxidative microbial destruction, extracellular trap formation, and the release of antimicrobial substances. MCs also contribute to host defense through the attraction and activation of phagocytic and inflammatory cells, shaping the innate and adaptive immune responses. However, as part of their response to pathogens and under an impaired, sustained, or systemic activation, MCs may contribute to tissue damage. This review will focus on the current knowledge about direct and indirect contribution of MCs to pathogen clearance. Antimicrobial mechanisms of MCs are addressed with special attention to signaling pathways involved and molecular weapons implicated. The role of MCs in a dysregulated host response that can increase morbidity and mortality is also reviewed and discussed, highlighting the complexity of MCs biology in the context of host-pathogen interactions.https://www.frontiersin.org/articles/10.3389/fimmu.2021.685865/fullmast cellsphagocytosisextracellular trapsmast cell mediatorspathology development participationsignaling pathways |
| spellingShingle | Mariela Jiménez Daniel Cervantes-García Daniel Cervantes-García Laura E. Córdova-Dávalos Marian Jesabel Pérez-Rodríguez Claudia Gonzalez-Espinosa Eva Salinas Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles Frontiers in Immunology mast cells phagocytosis extracellular traps mast cell mediators pathology development participation signaling pathways |
| title | Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles |
| title_full | Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles |
| title_fullStr | Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles |
| title_full_unstemmed | Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles |
| title_short | Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles |
| title_sort | responses of mast cells to pathogens beneficial and detrimental roles |
| topic | mast cells phagocytosis extracellular traps mast cell mediators pathology development participation signaling pathways |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.685865/full |
| work_keys_str_mv | AT marielajimenez responsesofmastcellstopathogensbeneficialanddetrimentalroles AT danielcervantesgarcia responsesofmastcellstopathogensbeneficialanddetrimentalroles AT danielcervantesgarcia responsesofmastcellstopathogensbeneficialanddetrimentalroles AT lauraecordovadavalos responsesofmastcellstopathogensbeneficialanddetrimentalroles AT marianjesabelperezrodriguez responsesofmastcellstopathogensbeneficialanddetrimentalroles AT claudiagonzalezespinosa responsesofmastcellstopathogensbeneficialanddetrimentalroles AT evasalinas responsesofmastcellstopathogensbeneficialanddetrimentalroles |