Musashi-1 Is a Novel Immunohistochemical Marker of Neuroendocrine Carcinoma of the Lung
Small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC) have recently been grouped as lung neuroendocrine carcinomas (NECs). Because these lung NECs are clinically malignant and their treatment strategies differ from those of non-SCLC, the quality of diagnosis has a significant...
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MDPI AG
2023-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/23/5631 |
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| author | Yu Izaki Vishwa Jeet Amatya Takahiro Kambara Kei Kushitani Yoshihiro Miyata Morihito Okada Yukio Takeshima |
| author_facet | Yu Izaki Vishwa Jeet Amatya Takahiro Kambara Kei Kushitani Yoshihiro Miyata Morihito Okada Yukio Takeshima |
| author_sort | Yu Izaki |
| collection | DOAJ |
| description | Small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC) have recently been grouped as lung neuroendocrine carcinomas (NECs). Because these lung NECs are clinically malignant and their treatment strategies differ from those of non-SCLC, the quality of diagnosis has a significant prognostic impact. The diagnosis of LCNEC requires positive immunohistochemical staining with chromogranin A, synaptophysin, and CD56, along with a morphological diagnosis, and insulinoma-associated protein 1 (INSM1) has been proposed as an additional marker but is still not an ideal or better marker. We investigated Musashi-1 as a novel immunohistochemical marker in 42 patients with SCLCs and 44 with LCNECs who underwent lung resection between 1998 and 2020 at our institution. We found Musashi-1 expression in 98% (41/42) SCLC and in 90% (40/44) LCNEC. These findings were similar to CD56 expression and superior to synaptophysin, chromogranin A, and INSM1. Musashi-1 also tended to show more diffuse and intense staining, especially in LCNEC, with more cases staining > 10% than any other existing markers (Musashi-1, 77%; INSM1, 45%; chromogranin A, 34%; synaptophysin, 41%; and CD56, 66%). In conclusion, we identified Musashi-1 as a novel immunohistochemical staining marker to aid in the diagnosis of lung NEC. |
| first_indexed | 2024-03-09T01:53:29Z |
| format | Article |
| id | doaj.art-0cd91be4d64a4a57b5956dbff7881412 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T01:53:29Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0cd91be4d64a4a57b5956dbff78814122023-12-08T15:12:46ZengMDPI AGCancers2072-66942023-11-011523563110.3390/cancers15235631Musashi-1 Is a Novel Immunohistochemical Marker of Neuroendocrine Carcinoma of the LungYu Izaki0Vishwa Jeet Amatya1Takahiro Kambara2Kei Kushitani3Yoshihiro Miyata4Morihito Okada5Yukio Takeshima6Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, JapanSmall cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC) have recently been grouped as lung neuroendocrine carcinomas (NECs). Because these lung NECs are clinically malignant and their treatment strategies differ from those of non-SCLC, the quality of diagnosis has a significant prognostic impact. The diagnosis of LCNEC requires positive immunohistochemical staining with chromogranin A, synaptophysin, and CD56, along with a morphological diagnosis, and insulinoma-associated protein 1 (INSM1) has been proposed as an additional marker but is still not an ideal or better marker. We investigated Musashi-1 as a novel immunohistochemical marker in 42 patients with SCLCs and 44 with LCNECs who underwent lung resection between 1998 and 2020 at our institution. We found Musashi-1 expression in 98% (41/42) SCLC and in 90% (40/44) LCNEC. These findings were similar to CD56 expression and superior to synaptophysin, chromogranin A, and INSM1. Musashi-1 also tended to show more diffuse and intense staining, especially in LCNEC, with more cases staining > 10% than any other existing markers (Musashi-1, 77%; INSM1, 45%; chromogranin A, 34%; synaptophysin, 41%; and CD56, 66%). In conclusion, we identified Musashi-1 as a novel immunohistochemical staining marker to aid in the diagnosis of lung NEC.https://www.mdpi.com/2072-6694/15/23/5631pathological diagnosisMusashi-1small cell carcinomalarge cell neuroendocrine carcinomalung cancersurgical specimen |
| spellingShingle | Yu Izaki Vishwa Jeet Amatya Takahiro Kambara Kei Kushitani Yoshihiro Miyata Morihito Okada Yukio Takeshima Musashi-1 Is a Novel Immunohistochemical Marker of Neuroendocrine Carcinoma of the Lung Cancers pathological diagnosis Musashi-1 small cell carcinoma large cell neuroendocrine carcinoma lung cancer surgical specimen |
| title | Musashi-1 Is a Novel Immunohistochemical Marker of Neuroendocrine Carcinoma of the Lung |
| title_full | Musashi-1 Is a Novel Immunohistochemical Marker of Neuroendocrine Carcinoma of the Lung |
| title_fullStr | Musashi-1 Is a Novel Immunohistochemical Marker of Neuroendocrine Carcinoma of the Lung |
| title_full_unstemmed | Musashi-1 Is a Novel Immunohistochemical Marker of Neuroendocrine Carcinoma of the Lung |
| title_short | Musashi-1 Is a Novel Immunohistochemical Marker of Neuroendocrine Carcinoma of the Lung |
| title_sort | musashi 1 is a novel immunohistochemical marker of neuroendocrine carcinoma of the lung |
| topic | pathological diagnosis Musashi-1 small cell carcinoma large cell neuroendocrine carcinoma lung cancer surgical specimen |
| url | https://www.mdpi.com/2072-6694/15/23/5631 |
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