Lymphocyte subset reference intervals in blood donors from northeastern Brazil
The reference intervals for leukocytes and lymphocytes currently used by most clinical laboratories present limitations as they are primarily derived from individuals of North American and European origin. The objective this study was to determine reference values for peripheral blood B lymphocytes,...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2015-06-01
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| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201019&lng=en&tlng=en |
| _version_ | 1819053337268453376 |
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| author | ALEX J.L. TORRES PATRÍCIA CISNEIROS ROSA GUEDES MARIA FERNANDA R. GRASSI ROBERTO MEYER MARIA T. BENDICHO TAIS G.S.L. LOPES GABRIELA FÉLIX EDUARDO M. NETTO CARLOS BRITES KIYOKO ABE-SANDES CLAUDIO BRANDÃO NEUZA ALCANTARA-NEVES SONGELI M. FREIRE |
| author_facet | ALEX J.L. TORRES PATRÍCIA CISNEIROS ROSA GUEDES MARIA FERNANDA R. GRASSI ROBERTO MEYER MARIA T. BENDICHO TAIS G.S.L. LOPES GABRIELA FÉLIX EDUARDO M. NETTO CARLOS BRITES KIYOKO ABE-SANDES CLAUDIO BRANDÃO NEUZA ALCANTARA-NEVES SONGELI M. FREIRE |
| author_sort | ALEX J.L. TORRES |
| collection | DOAJ |
| description | The reference intervals for leukocytes and lymphocytes currently used by most clinical laboratories present limitations as they are primarily derived from individuals of North American and European origin. The objective this study was to determine reference values for peripheral blood B lymphocytes, T lymphocyte subsets (CD4+, CD8+, naïve, memory, regulatory, TCRαβ and TCRγδ+) and NK cells from blood donors in Salvador-Bahia, Brazil. Results: The proportion of included male subjects was 73.7% and the median ages of males (34) and females (35) were found to be similar. Absolute counts total lymphocytes subsets to both gender was 1,956 (1,060-4,186) cells and relative values 34%. The T CD4+ and T CD8+ lymphocytes relative values was 51% (20-62) and 24% (9-28), respectively. The most statistically significant finding observed was a higher percentage of B lymphocytes (p=0.03) in females. Commonly cited subset reference intervals were found to be consistent with values in several populations from different geographic areas. |
| first_indexed | 2024-12-21T12:34:07Z |
| format | Article |
| id | doaj.art-0cd9ec35419b443cb9b1d8ebfc099495 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-21T12:34:07Z |
| publishDate | 2015-06-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-0cd9ec35419b443cb9b1d8ebfc0994952022-12-21T19:03:58ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902015-06-018721019102510.1590/0001-3765201520130114S0001-37652015000201019Lymphocyte subset reference intervals in blood donors from northeastern BrazilALEX J.L. TORRESPATRÍCIA CISNEIROSROSA GUEDESMARIA FERNANDA R. GRASSIROBERTO MEYERMARIA T. BENDICHOTAIS G.S.L. LOPESGABRIELA FÉLIXEDUARDO M. NETTOCARLOS BRITESKIYOKO ABE-SANDESCLAUDIO BRANDÃONEUZA ALCANTARA-NEVESSONGELI M. FREIREThe reference intervals for leukocytes and lymphocytes currently used by most clinical laboratories present limitations as they are primarily derived from individuals of North American and European origin. The objective this study was to determine reference values for peripheral blood B lymphocytes, T lymphocyte subsets (CD4+, CD8+, naïve, memory, regulatory, TCRαβ and TCRγδ+) and NK cells from blood donors in Salvador-Bahia, Brazil. Results: The proportion of included male subjects was 73.7% and the median ages of males (34) and females (35) were found to be similar. Absolute counts total lymphocytes subsets to both gender was 1,956 (1,060-4,186) cells and relative values 34%. The T CD4+ and T CD8+ lymphocytes relative values was 51% (20-62) and 24% (9-28), respectively. The most statistically significant finding observed was a higher percentage of B lymphocytes (p=0.03) in females. Commonly cited subset reference intervals were found to be consistent with values in several populations from different geographic areas.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201019&lng=en&tlng=enSubgrupos de linfócitosvalores de referênciascitometria de fluxoBrasildoadores de sangue |
| spellingShingle | ALEX J.L. TORRES PATRÍCIA CISNEIROS ROSA GUEDES MARIA FERNANDA R. GRASSI ROBERTO MEYER MARIA T. BENDICHO TAIS G.S.L. LOPES GABRIELA FÉLIX EDUARDO M. NETTO CARLOS BRITES KIYOKO ABE-SANDES CLAUDIO BRANDÃO NEUZA ALCANTARA-NEVES SONGELI M. FREIRE Lymphocyte subset reference intervals in blood donors from northeastern Brazil Anais da Academia Brasileira de Ciências Subgrupos de linfócitos valores de referências citometria de fluxo Brasil doadores de sangue |
| title | Lymphocyte subset reference intervals in blood donors from northeastern Brazil |
| title_full | Lymphocyte subset reference intervals in blood donors from northeastern Brazil |
| title_fullStr | Lymphocyte subset reference intervals in blood donors from northeastern Brazil |
| title_full_unstemmed | Lymphocyte subset reference intervals in blood donors from northeastern Brazil |
| title_short | Lymphocyte subset reference intervals in blood donors from northeastern Brazil |
| title_sort | lymphocyte subset reference intervals in blood donors from northeastern brazil |
| topic | Subgrupos de linfócitos valores de referências citometria de fluxo Brasil doadores de sangue |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201019&lng=en&tlng=en |
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