Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis.
<h4>Background</h4>Low vitamin D status (serum 25(OH)D concentration) is associated with increased incidence and unfavourable outcome of various types of cancer. However, there are limited data on influence of serum 25(OH)D on risk and prognosis of malignant melanoma.<h4>Methods<...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112863&type=printable |
| _version_ | 1826587331940843520 |
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| author | Benjamin Bade Alexander Zdebik Stefan Wagenpfeil Stefan Gräber Jürgen Geisel Thomas Vogt Jörg Reichrath |
| author_facet | Benjamin Bade Alexander Zdebik Stefan Wagenpfeil Stefan Gräber Jürgen Geisel Thomas Vogt Jörg Reichrath |
| author_sort | Benjamin Bade |
| collection | DOAJ |
| description | <h4>Background</h4>Low vitamin D status (serum 25(OH)D concentration) is associated with increased incidence and unfavourable outcome of various types of cancer. However, there are limited data on influence of serum 25(OH)D on risk and prognosis of malignant melanoma.<h4>Methods</h4>Basal serum 25(OH)D concentrations were retrospectively analyzed in a cohort of melanoma patients (n = 324) and healthy controls (n = 141). We tested the hypothesis that serum 25(OH)D concentrations are predictive of melanoma risk, thickness of primary melanomas, and overall survival (OS).<h4>Results</h4>Median serum 25(OH)D concentrations were significantly lower (p = 0.004) in melanoma patients (median = 13.6 ng/ml) as compared to controls (median = 15.6 ng/ml). Primary tumors of patients with low serum 25(OH)D concentrations (<10 ng/ml) had significantly (p = 0.006) greater Breslow thickness (median: 1.9 mm) as compared to patients with higher levels (>20 ng/ml; median: 1.00 mm). Patients with 25(OH)D serum concentrations in the lowest quartile had inferior overall survival (median: 80 months) comparing with the highest quartile (median: 195 months; p = 0.049).<h4>Conclusions</h4>Our data support the concept that serum 25(OH)D concentrations are associated with risk and prognosis of melanoma. Whether normalizing serum 25(OH)D concentrations in these patients improves outcomes will require testing in future clinical trials. |
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| format | Article |
| id | doaj.art-0cdad9c6b3484d819e59f91af411ec2c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-14T16:23:45Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0cdad9c6b3484d819e59f91af411ec2c2025-02-22T05:32:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11286310.1371/journal.pone.0112863Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis.Benjamin BadeAlexander ZdebikStefan WagenpfeilStefan GräberJürgen GeiselThomas VogtJörg Reichrath<h4>Background</h4>Low vitamin D status (serum 25(OH)D concentration) is associated with increased incidence and unfavourable outcome of various types of cancer. However, there are limited data on influence of serum 25(OH)D on risk and prognosis of malignant melanoma.<h4>Methods</h4>Basal serum 25(OH)D concentrations were retrospectively analyzed in a cohort of melanoma patients (n = 324) and healthy controls (n = 141). We tested the hypothesis that serum 25(OH)D concentrations are predictive of melanoma risk, thickness of primary melanomas, and overall survival (OS).<h4>Results</h4>Median serum 25(OH)D concentrations were significantly lower (p = 0.004) in melanoma patients (median = 13.6 ng/ml) as compared to controls (median = 15.6 ng/ml). Primary tumors of patients with low serum 25(OH)D concentrations (<10 ng/ml) had significantly (p = 0.006) greater Breslow thickness (median: 1.9 mm) as compared to patients with higher levels (>20 ng/ml; median: 1.00 mm). Patients with 25(OH)D serum concentrations in the lowest quartile had inferior overall survival (median: 80 months) comparing with the highest quartile (median: 195 months; p = 0.049).<h4>Conclusions</h4>Our data support the concept that serum 25(OH)D concentrations are associated with risk and prognosis of melanoma. Whether normalizing serum 25(OH)D concentrations in these patients improves outcomes will require testing in future clinical trials.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112863&type=printable |
| spellingShingle | Benjamin Bade Alexander Zdebik Stefan Wagenpfeil Stefan Gräber Jürgen Geisel Thomas Vogt Jörg Reichrath Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis. PLoS ONE |
| title | Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis. |
| title_full | Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis. |
| title_fullStr | Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis. |
| title_full_unstemmed | Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis. |
| title_short | Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis. |
| title_sort | low serum 25 hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112863&type=printable |
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