Relationship Among Homocysteine, Inflammation and Cognitive Impairment in Patients with Acute Ischemic Stroke and Transient Ischemic Attack
Lingyun Cui,1 Ping Lu,1 Shiyu Li,1 YueSong Pan,2 Mengxing Wang,2 Zixiao Li,1,2 Xiaoling Liao,1,2 Yongjun Wang1,2 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Be...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-12-01
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| Series: | Neuropsychiatric Disease and Treatment |
| Subjects: | |
| Online Access: | https://www.dovepress.com/relationship-among-homocysteine-inflammation-and-cognitive-impairment--peer-reviewed-fulltext-article-NDT |
| _version_ | 1818459381148155904 |
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| author | Cui L Lu P Li S Pan Y Wang M Li Z Liao X Wang Y |
| author_facet | Cui L Lu P Li S Pan Y Wang M Li Z Liao X Wang Y |
| author_sort | Cui L |
| collection | DOAJ |
| description | Lingyun Cui,1 Ping Lu,1 Shiyu Li,1 YueSong Pan,2 Mengxing Wang,2 Zixiao Li,1,2 Xiaoling Liao,1,2 Yongjun Wang1,2 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Beijing, People’s Republic of ChinaCorrespondence: Yongjun WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119#Nan Si Huan Xi Lu, Beijing, 100070, People’s Republic of ChinaTel +86 10-59978351Email yongjunwang@ncrcnd.org.cnPurpose: To investigate the associations among homocysteine (Hcy), inflammation and cognitive impairment in patients with acute ischemic stroke (AIS) and transient ischemic attack (TIA).Patients and Methods: Patients included were enrolled from a subgroup of China National Stroke Registry-III (CNSR-III). We used a Chinese version of Montreal Cognitive Assessment (MoCA) to screen for cognitive impairment. We used high-sensitivity C-reactive protein (hsCRP) level to reflect the inflammatory status, which was assessed at baseline together with Hcy concentration. The primary outcome was the incidence of post-stroke cognitive impairment (PSCI) at 3 months after AIS and TIA. Multivariable logistic regression analysis was used to evaluate the correlation between Hcy and hsCRP, and their effects on cognition.Results: We enrolled 1466 patients with a median age of 62 (54– 70) years old, including 895 (61.05%) patients with elevated Hcy levels, 466 (31.79%) with increased hsCRP concentrations, and 755 (51.50%) with PSCI. In the group of patients with hyperhomocysteinemia (HHcy), higher hsCRP levels were related to cognitive impairment, whether or not adjusted for multiple potential confounders (crude OR: 1.71,95% CI: 1.29– 2.27, p < 0.01; adjusted OR: 1.42, 95% CI: 1.04– 1.93, p = 0.03). No significant interactions for the impact on PSCI were observed in subgroups stratified by age, sex or Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification (P interaction > 0.05 for all).Conclusion: High inflammatory levels increase the risk of cognitive impairment in HHcy patients after AIS and TIA.Keywords: stroke, transient ischemic attack, inflammation, homocysteine, cognitive function |
| first_indexed | 2024-12-14T23:13:27Z |
| format | Article |
| id | doaj.art-0cdb65c2ee7a4515b4a89b7cf0a06e29 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-14T23:13:27Z |
| publishDate | 2021-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-0cdb65c2ee7a4515b4a89b7cf0a06e292022-12-21T22:44:08ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212021-12-01Volume 173607361671396Relationship Among Homocysteine, Inflammation and Cognitive Impairment in Patients with Acute Ischemic Stroke and Transient Ischemic AttackCui LLu PLi SPan YWang MLi ZLiao XWang YLingyun Cui,1 Ping Lu,1 Shiyu Li,1 YueSong Pan,2 Mengxing Wang,2 Zixiao Li,1,2 Xiaoling Liao,1,2 Yongjun Wang1,2 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Beijing, People’s Republic of ChinaCorrespondence: Yongjun WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119#Nan Si Huan Xi Lu, Beijing, 100070, People’s Republic of ChinaTel +86 10-59978351Email yongjunwang@ncrcnd.org.cnPurpose: To investigate the associations among homocysteine (Hcy), inflammation and cognitive impairment in patients with acute ischemic stroke (AIS) and transient ischemic attack (TIA).Patients and Methods: Patients included were enrolled from a subgroup of China National Stroke Registry-III (CNSR-III). We used a Chinese version of Montreal Cognitive Assessment (MoCA) to screen for cognitive impairment. We used high-sensitivity C-reactive protein (hsCRP) level to reflect the inflammatory status, which was assessed at baseline together with Hcy concentration. The primary outcome was the incidence of post-stroke cognitive impairment (PSCI) at 3 months after AIS and TIA. Multivariable logistic regression analysis was used to evaluate the correlation between Hcy and hsCRP, and their effects on cognition.Results: We enrolled 1466 patients with a median age of 62 (54– 70) years old, including 895 (61.05%) patients with elevated Hcy levels, 466 (31.79%) with increased hsCRP concentrations, and 755 (51.50%) with PSCI. In the group of patients with hyperhomocysteinemia (HHcy), higher hsCRP levels were related to cognitive impairment, whether or not adjusted for multiple potential confounders (crude OR: 1.71,95% CI: 1.29– 2.27, p < 0.01; adjusted OR: 1.42, 95% CI: 1.04– 1.93, p = 0.03). No significant interactions for the impact on PSCI were observed in subgroups stratified by age, sex or Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification (P interaction > 0.05 for all).Conclusion: High inflammatory levels increase the risk of cognitive impairment in HHcy patients after AIS and TIA.Keywords: stroke, transient ischemic attack, inflammation, homocysteine, cognitive functionhttps://www.dovepress.com/relationship-among-homocysteine-inflammation-and-cognitive-impairment--peer-reviewed-fulltext-article-NDTstroketransient ischemic attackinflammationhomocysteinecognitive function |
| spellingShingle | Cui L Lu P Li S Pan Y Wang M Li Z Liao X Wang Y Relationship Among Homocysteine, Inflammation and Cognitive Impairment in Patients with Acute Ischemic Stroke and Transient Ischemic Attack Neuropsychiatric Disease and Treatment stroke transient ischemic attack inflammation homocysteine cognitive function |
| title | Relationship Among Homocysteine, Inflammation and Cognitive Impairment in Patients with Acute Ischemic Stroke and Transient Ischemic Attack |
| title_full | Relationship Among Homocysteine, Inflammation and Cognitive Impairment in Patients with Acute Ischemic Stroke and Transient Ischemic Attack |
| title_fullStr | Relationship Among Homocysteine, Inflammation and Cognitive Impairment in Patients with Acute Ischemic Stroke and Transient Ischemic Attack |
| title_full_unstemmed | Relationship Among Homocysteine, Inflammation and Cognitive Impairment in Patients with Acute Ischemic Stroke and Transient Ischemic Attack |
| title_short | Relationship Among Homocysteine, Inflammation and Cognitive Impairment in Patients with Acute Ischemic Stroke and Transient Ischemic Attack |
| title_sort | relationship among homocysteine inflammation and cognitive impairment in patients with acute ischemic stroke and transient ischemic attack |
| topic | stroke transient ischemic attack inflammation homocysteine cognitive function |
| url | https://www.dovepress.com/relationship-among-homocysteine-inflammation-and-cognitive-impairment--peer-reviewed-fulltext-article-NDT |
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